**4.1.2 Hybrid hydrogels for cartilage regeneration**

Understanding of the tissue structure and composition can lead to a rational material design, targeted towards mimicking the underlying biological cues and specific chemistry of cartilage. Generally, in-situ forming hydrogels have been prepared from synthetic polymers, natural polymers or their hybrids. The latter has gained increasing attention in recent years because they combine the advantage of both synthetic and natural polymers, that is, tightly defined physical, chemical and biological properties. Table 1 lists typical examples of in-situ forming hybrid hydrogels for cartilage tissue regeneration.


Table 1. Typical examples of in-situ forming hybrid hydrogels for cartilage regeneration
