**3.13 P21-activated kinase 6**

Super-expression of P21-activated kinase 6 (encoded by PAK6) is detected in malignant prostate cancer tissues. Wen (Wen *et al,* 2009) compared the inhibitory effect of PAK6-target siRNA (by intratumor injection in transplanted pancreatic cancer tumor-bearing nude mice) and Taxol on tumors, where siRNA was injected into tumors of transplanted pancreatic cancer-bearing nude mice. The result of six-week observation showed that the mean tumor size of the control group, Taxol group, siRNA group and Taxol+siRNA group was 475mm3, 210mm, 68mm3 and 47mm3 respectively. PAK6-siRNA inhibited the growth of pancreatic cancer cells and blocked them at G2-M, demonstrating that both Taxol and PAK6-siRNA could inhibit tumor growth. The inhibitory effect of combined use of Taxol and PAK6 siRNA was significantly better than either of the two along.
