**6. Conclusion**

Fungal endocarditis is one of the most serious manifestations of invasive fungal infections. The first line of prevention is decreasing fungal conidia transition during surgery in operating rooms by using high-efficiency particulate air filters and sterile equipment. Early diagnosis and immediate appropriate antifungal therapy are critical for the survival of the respective patients. For high quality care of the patients, echocardiography with noncultural methods such as GM assay and PCR which can detect infection in early stages should be performed. In patients with suspected FE and positive test results, it is recommended that they receive antifungal agents pre-operation and also the clinical management be continued once the documented diagnosis is made based on the sample obtained in the operation room. As high relapses are common, treatment should be followed by careful review of the clinical, mycological (serum GM level and DNA load) and echocardiography sign and symptoms of the infections.
