Preface

Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory arthritis, which features destruction of synovial joints, systemic inflammation, functional disability, reduced quality of life, and increased morbidity and mortality. It is relatively common, having a world-wide prevalence of between 0.5-2%, and is associated with huge social and economic costs. Consequently, it is the most important of the inflammatory arthritides.

The aim of *Rheumatoid Arthritis - Treatment* is not to provide a comprehensive commentary on RA (several of these are already in publication), but rather to provide interesting, thought-provoking, and up-to-date perspectives on a variety of aspects of current research into this condition. In taking this approach, *Rheumatoid Arthritis - Treatment* includes topics not usually covered by conventional publications. As such, it is an ideal reference and source of inspiration and direction for investigators, whatever their level, in the challenging and exciting field of rheumatology research.

This book is sectioned into: "DMARDs (Disease Modifying Anti-Rheumatic Drugs) and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)" (chapters 1-2), "Biologics" (chapters 3-5), "Potential Therapies" (chapters 6-13), and "Exercise and Alternative Therapies" (chapters 14-17).

The editor would like to thank the chapter authors for their excellent contributions, and extend to them the wish that their current and future research endeavors are fruitful. Special thanks are also given to Anja Filipovic and other InTech staff for their expert editorial assistance in publishing this book.

RA is an exciting condition to investigate. Hopefully, this book will help to advance research into the mechanisms and treatment of the disease.

> **Dr. Andrew B. Lemmey**  School of Sport, Health & Exercise Sciences College of Health & Behavioral Sciences Bangor University UK

**Part 1** 

**DMARDs (Disease Modifying Anti-Rheumatic** 

**Drugs) and NSAIDs (Non-Steroidal** 

 **Anti-Inflammatory Drugs)** 
