**3.1 Resveratrol induces MH7A cell apoptosis**

In the MTT assay, resveratrol reduced MH7A cell viability in a concentration (1-200 M) and treatment time (24-72 h)-dependent manner (Fig. 1A), suggesting that resveratrol induces MH7A cell death.

Resveratrol increased TUNEL-positive cells in a concentration (100-200 M)-dependent manner (Fig. 1B), indicating that resveratrol induces MH7A cell apoptosis. DNA damage or apoptosis is recognized to stimulate phosphorylation of histone H2A.X. Resveratrol (100 M) significantly enhanced H2A.X phosphorylation, the extent reaching approximately 13 fold of control levels (Fig. 1C). This provides further evidence for resveratrol-induced MH7A cell apoptosis.
