**RP in High-grade PCa: Gleason score 8-10**

In this group of patients, the incidence of organ-confined disease is around 26% to 31%. The PSA value and percentage of positive prostate biopsies may help to select men with highgrade PCa most likely to benefit from RP.

Rioja Zuazu J. et al. (38) analyzed the characteristics of the clinical Gleason 8-10 group of patients within their series of patients diagnosed with prostate cancer and treated by means of radical prostatectomy, and tried to ascertain which were the influence factors within this group, upon progression and progression free survival. They conclude, that Clinical Gleason Score 8-10 is a negative independent prognostic factor on the progression free survival, but its prognosis is better if they present a PSA prior surgery lower than 11 ng/ml and the pathological stage is a pT2. So, these kind of patients could be beneficed of RP.
