**4. Prostate cancer cells and adipocytes**

Skeletal metastases are most common in advanced Pca. Metastases are known to be osteoblastic ones. Prostate cancer cells are absorbing lipids directly to develop and progress, that is why bone marrow is so common place of metastases.

 It was also experimentally shown that bone marrow without adypocytes is less attractive for prostate cancer cells to residue (Brown et al., 2006). It was even suggested that lowering lipid levels with statins will impact the progression of prostate cancer, but this assumption turned out not to be true (Platz et al., 2006).
