**7. Local control**

Local control, main objective with both techniques, is better achieved with surgery. Local relapse rates between 3-30%(63-65) Depends on clinical stage (pT2: 2-7%; negative margins 7%; pT3-4: 40%; positive margin 27%) While with Radiotherapy, local recurrence rate is for T1: 17-22% (Standford); 4.6% (Schelhamer); T2: 19%-35%.

The rate of positive biopsies is between 20-70%, although is difficult to classify its meaning, they highlight disease and progression. It depend on clinical stage (B=17%, C=59%) and Gleason score. A valuable biopsy is at 18 months after finishing treatment.

Frequency of positive prostate biopsies on patients whom underwent radiotherapy, is around 38% on average.

In the study (66) with 100 patients, with biopsy every 6 months showed following results T-1b: 21%; en T-2a: 24%; en T-2b-c: 28%.

There is no doubt regarding its prognostic value. Although the pioneers showing these results were Rhamy (1972) and Sewel (1975) Scardino has been reporting, and highlighting its value (67). At Baylor-Collegue (Houston) 147 patients treated with Au 198 and external bean radiotherapy, clinical stage A2, B, C with pelvic lymphadenectomy. They had a positive biopsy rate of 42%, 36%, 28% at 6, 12 and 18 months. The chance of local recurrence at 5 years for positive and negative biopsies is around 52% and 12%, and at 10 years of 72% and 30%.
