**Meet the editor**

Dr Philippe E. Spiess is an assistant professor with dual appointment in the department of Genitourinary Oncology at the Moffitt Cancer Center and the department of Urology at the University of South Florida in Tampa, Florida. Dr Spiess was born and raised in Montreal, Canada where he completed his urological training at Mc-Gill University. He subsequently completed his urologic

oncologic training at the M. D. Anderson Cancer Center in Houston, Texas. Dr Spiess has published over 80 peer reviewed scientific papers in urologic oncology in addition to being a nationally and internationally recognized expert in the management of genitourinary malignancies. He has dedicated much of his research efforts to optimizing the surgical management of locally advanced and locally recurrent prostate cancer. He currently sits on the NCCN Panel for bladder and penile cancer in addition to being the video section editor of the International Brazilian Journal of Urology.

Contents

**Preface IX** 

Philipp Wolf

Tine Hajdinjak

**Part 2 Surgical Treatment Options 131** 

Chapter 7 **High-Intensity Focused Ultrasound (HIFU) -** 

Chapter 8 **Radiotherapy in Prostate Cancer 169** 

Umberto Maestroni and Francesco Ziglioli

Tatjana Arsenijević, Kata Dabić Stanković, Miodrag Aćimović and Ljiljana Radošević Jelić

**Part 3 Radiation Therapy and Its Potential Sequelae 167** 

**Part 1 Novel Diagnostic Approaches 1** 

Chapter 1 **Biomarkers of Aggressiveness in Prostate Cancer 3**  Cuvillier Olivier and Malavaud Bernard

Piotr Bryniarski, Andrzej Paradysz and Mieczysław Fryczkowski

Chapter 3 **Renewing Perspectives on Men's Prostate Cancer Literacy and Engagement Along the Disease Continuum 37**  Margareth Santos Zanchetta, Margot Kaszap, Marko Monteiro,

**and Therapeutic Target for Prostate Cancer 81** 

Chapter 5 **Future of Prostate Biopsy: Who Will Get It and How? 101** 

Chapter 6 **Radical Prostatectomy in High Risk Prostate Cancer 133**  Jorge Rioja, Carlos Blanco and Jorge Aranda

**An Alternative Choice in Prostate Cancer Treatment 151** 

Chapter 2 **The Influence of Obesity on Prostate Cancer Diagnosis and Treatment 21** 

Franklin Gorospe IV and Roger Pilon

Chapter 4 **Prostate Specific Membrane Antigen as Biomarker** 
