**Meet the editor**

Dr Alexandros G. Georgakilas is an Associate Professor of Biology at East Carolina University (ECU) in Greenville, NC. He is responsible for the DNA Damage and Repair laboratory at ECU, USA, and has trained several graduate (1 PhD and 8 MSc) and undergraduate students. His work has been funded by various sources like East Carolina University, NC Biotechnology Center and

International Cancer Control (UICC), which is the largest cancer fighting organization of its kind with more than 400 member organizations across 120 countries. He holds several editorial positions in scientific journals and his research work has been published in more than 50 peer-reviewed high profile journals like Cancer Research, Journal of Cell Biology and Proceedings of National Academy of Sciences USA, and has more than 900 citations. Ultimately, he hopes to translate his work of basic research into clinical applications using DNA damage clusters as cancer or radiation biomarkers for oxidative stress.

Contents

**Preface IX** 

**Section 1 Mechanisms of Carcinogenesis,** 

Chapter 2 **Inflammatory ROS in Fanconi** 

Chapter 4 **Kaiso and Prognosis of Cancer** 

Jaime Cofre

Chapter 7 **Risk and Protective Factors** 

Iskren Kotzev

Chapter 8 **Colorectal Cancer and** 

Sayori Wada

Wei Du

Chapter 1 **Targeting Tumor Microenvironments** 

Chapter 3 **Staying a Step Ahead of Cancer 63** 

**for Cancer Prevention and Therapy 3**  Li V. Yang, Reid D. Castellone and Lixue Dong

**in the Current Epigenetic Paradigm 107** 

Chapter 5 **Targeting Molecular Pathways for Prevention of High** 

**Section 2 Dietary and Lifestyle Patterns in Cancer Prevention 149** 

Budimka Novaković, Jelena Jovičić and Maja Grujičić

**the Preventive Effects of Food Components 207** 

Shayna Showalter and Brian J. Czerniecki

Chapter 6 **Lifestyle Changes May Prevent Cancer 151** 

**Anemia Hematopoiesis and Leukemogenesis 41** 

**Role of Oxidative Stress, Inflammation and DNA Damage 1** 

Somaira Nowsheen, Alexandros G. Georgakilas and Eddy S. Yang

**Risk Breast Cancer: A Model for Cancer Prevention 131** 

**for Development of Colorectal Polyps and Cancer 179** 
