**1. Introduction**

178 Cancer Prevention – From Mechanisms to Translational Benefits

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CRC is one of the most frequently diagnosed neoplastic disorders in humans worldwide. According to the National Centre for Health Information of Bulgaria the prevalence of CRC for 2005 is 304.6/100 000 cases, and the incidence - 49.2/100 000 cases (Bulletin of the National Centre for Health Information, 2005). Colorectal polyps (CRP) are established precursors of CRC. Hence, elimination of precursors is a well-known strategy for reduction of risk. In the last decade the most extensively studied etiologic factors are the risk factors for colorectal cancer development, because of its growing incidence and the possibility for its prevention. Prophylaxis of CRC we can divide in primary, secondary and tertiary. The most widely used chemopreventive drugs are: acetylsalicylic acid, polyvitamins, calcium, folic acid, selenium and NSAID.
