**Targeting Tumor Microenvironments for Cancer Prevention and Therapy**

Li V. Yang1,2,3, Reid D. Castellone1 and Lixue Dong1 *1Department of Internal Medicine, Division of Hematology/Oncology, 2Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, 3UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, U.S.A.* 
