Contents

### **Preface XIII**


X Contents


Contents VII

Chapter 19 **Reducing False Positives in a Computer-Aided Diagnosis Scheme for Detecting Breast Microcalcificacions:** 

and Carmen Cadarso Suárez

Javier Roca-Pardiñas, María J. Lado, Pablo G. Tahoces

**A Quantitative Study with Generalized Additive Models 459** 

Chapter 19 **Reducing False Positives in a Computer-Aided Diagnosis Scheme for Detecting Breast Microcalcificacions: A Quantitative Study with Generalized Additive Models 459**  Javier Roca-Pardiñas, María J. Lado, Pablo G. Tahoces and Carmen Cadarso Suárez

VI Contents

Chapter 9 **Cervical Cancer Screening and Prevention** 

Sharon Kibwana and Anjanique Lu

A.C. Kaliora and A.M. Kountouri

Qihan Dong and Paul L de Souza

Chapter 13 **The Therapeutic Potential of Pomegranate** 

**and Advances from the Clinic 373**

**for Cancer Prevention and Control:** 

D. James Morré and Dorothy M. Morré

Roy Weiner and Farah A. Arosemena

**of Prostate Cancer Chemoprevention:** 

**Strategies in Endometrial Cancer 441** 

Jason M. Phillips and E. David Crawford

**Current Strategies and Future Directions 429**

Dan Ancuşa, Gheorghe Furău, Adrian Carabineanu, Răzvan Ilina, Octavian Neagoe and Marius Craina

Chapter 16 **Creating a Sustainable Cancer Workforce:**

Chapter 10 **Chemopreventive Activity** 

Chapter 12 **Phytoestrogens as Nutritional** 

**Section 3 Strategies for Treatment**

Chapter 14 **Strategic Communication**

Gary L. Kreps

Chapter 17 **The Changing Landscape** 

Chapter 18 **Prevention and Therapeutic**

Chapter 15 **Early Detection: An Opportunity** 

Chapter 11 **Dietary Manipulation** 

Jean Anderson, Enriquito Lu, Harshad Sanghvi,

**of Mediterranean Medicinal Plants 261**

**for Therapeutic Effect in Prostate Cancer 285**

**Modulators in Colon Cancer Prevention 321**  Michele Barone, Raffaele Licinio and Alfredo Di Leo

**and Its Products for Prevention of Cancer 331**  Arzu Akpinar-Bayizit, Tulay Ozcan and Lutfiye Yilmaz-Ersan

**Reaching and Influencing Vulnerable Audiences 375**

**for Cancer Prevention Through Early Intervention 389**

**Focus on Disparities and Cultural Competence 403** 

Maureen Y. Lichtveld, Lovell Jones, Alison Smith, Armin Weinberg,

**for HIV-Infected Women in the Developing World 231** 

Carol A Gano, Kieran Scott, Joseph Bucci, Heather Greenfield,

Preface

clinical approaches and associated topics.

pathways for prevention of high-risk breast cancer.

There is growing evidence on the importance of studies focusing on mechanisms and strategies leading to cancer prevention. The plethora of approaches include regulation of oxidative stress using antioxidant therapies, carefully balanced diets and living habits, epidemiological evidence and molecular approaches on the role of key biological molecules such as antioxidant enzymes, vitamins, proteins and naturally occurring free radical scavengers as well as controversial results and clinical applications. These are some of the topics that this book highlights. Furthermore, it provides comprehensive reviews of the state-of-the-art techniques and advances of cancer prevention research of different areas and how all this knowledge can be translated into therapeutic benefits as well as controversies. The primary target audience for the book includes PhD students, researchers, biologists, medical doctors and professionals who are interested in mechanistic studies on cancer prevention,

In section 1, top experts discuss a diverse set of carcinogenesis mechanisms with emphasis in oxidative stress, DNA damage and inflammation. Specifically, Dr Li Yang and colleagues discuss the targeting of tumor microenvironments and cancer prevention. Dr Du's chapter concentrates on the role of inflammatory reactive oxygen species (ROS) in Fanconi anemia hematopoiesis and leukemogenesis. Dr Eddy Yang and colleagues concentrate on the interplay between inflammation, DNA damage and cancer exploring the positive roles of vitamin D, retinoid and antioxidants. Dr Cofre's chapter focuses on Kaiso protein and prognosis of cancer discussing especially the role of immunohistochemistry in the current epigenetic paradigm. Finally, for this section, Drs. Showalter and Czerniecki 'dissect' very successfully the targeting of molecular

In section 2, chapters focus on the contribution of specific dietary and lifestyle patterns to cancer as well as in prevention. Dr Novaković and colleagues discuss how nutrition, physical activity, tobacco and alcohol use may contribute to carcinogenesis and the necessary lifestyle changes to prevent the appearance of a malignancy. Dr Kotzev's chapter concentrates on the prevention of colorectal cancer and especially the various risk and protective factors for colorectal polyps and cancer. Dr. Wada's work focuses on the preventive effects of food components and commonly used supplements in colorectal cancer as well as controversies. Dr Kaliora's and Dr Kountouri's chapter
