**4.3** *In vivo* **data**

In a PC3 xenograft study, resveratrol alone inhibited tumour growth, enhanced TRAIL induced apoptosis, and inhibited angiogenenesis (Ganapathy et al., 2010). Resveratrol is also able to reduce or delay prostate cancer in the TRAMP mouse model (Slusarz et al., 2010), possibly via inhibition of HedgeHog signaling. Conflicting evidence was provided by Wang et al., (2008), who found that resveratrol increased angiogenesis and inhibited apoptosis, at least in LNCaP xenografts.
