**1. Introduction**

330 Cancer Prevention – From Mechanisms to Translational Benefits

[50] Peipins A, Newman B, Sandler RS (1997) Use of exogenous hormones and risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 6(4):671–675 [51] Weyant MJ, Carothers AM, Mahmoud NN et al (2001) Reciprocal expression of ERalpha

[52] Theodoratou E. et al. (2007) Dietary flavonoids and the risk of colorectal cancer. Cancer

[53] Cotterchio M et al. (2006) Dietary phytoestrogen intake is associated with reduced

[54] Axelson M, Sjo¨vall J, Gustafsson BE, Setchell KD (1982) Origin of lignans in mammals and identification of a precursor from plants. Nature 298(5875):659–660 [55] Kuijsten A, Arts ICW, Holmann PCH, van't Veer P, Kampman E (2006) Plasma

[56] Touillaud, M.S. et al. (2007) Dietary lignan intake and postmenopausal breast cancer risk by estrogen and progesterone receptor status. J. NatlCancer Inst., 99, 475–486 [57] Di Leo Alfredo et al. (2011) Human sporadic adenocarcinoma and dietary management

tumorigenesis. Cancer Res 6(1):2547–2551

Epidemiol Biomarkers Prev 16(4):684–693

Biomarkers Prev 15(6):1132–1136

colorectal cancer risk. J Nutr 136(12):3046–3053

colonoscopy. Submitted to GASTROENTEROLOGY.

and ERb is associated with estrogen-mediated modulation of intestinal

enterolignans are associated with lower colorectaladenoma risk. Cancer Epidemiol

of Estrogen Receptors (ERs)-driven biomarkers of proliferation and apoptosis (Ki-67; caspase 3, TUNEL) in the colorectal mucosa of patients undergoing screening Pomegranate (*Punica granatum* L.) is considered one of the oldest known edible fruits and is the symbolic of abundance and prosperity. For thousand of years, many cultures have believed that pomegranate have beneficiary effects on health, fertility, longevity and rebirth. The recent interest for this fruit is not only because of the pleasant taste, but also due to the scientific evidences that suggest therapeutic activity such as anti-atherogenic, antiparasitic, antimicrobial, antioxidant, anticarcinogenic and antiinflammatory effects. These beneficial effects were attributed to the antioxidative properties of pomegranate phenolic compounds, tannins and anthocyanins as well as other phytochemicals. The constituents of pomegranate have been thoroughly investigated, however, clinical trials are in progress to explore the therapeutic potential of pomegranate products, particularly determining preventive efficacy of pomegranate extracts in cancer, cardiovascular diseases, inflammation, diabetes and ultraviolet radiation-induced skin damage. In order to facilitate the further investigations the information contained in this work is based upon the immense work on impact of administration of pomegranate extracts*,* particularly in cancer prevention such as skin, prostate, breast, and colon.
