**3.8 Crystalline vs. amorphous paclitaxel**

The formulations made with crystalline and amorphous paclitaxel were administered orally to mice (Figure 4F). The pharmacokinetic profiles were virtually identical for these two formulations. We expected that the crystallinity of the drug would not affect the degree of oral absorption since paclitaxel was dissolved completely in tricaprylin/dichloromethane mixture before adding other ingredients, and therefore, the final products would be identical.

## **3.9 Formulation without Tween 80**

Oral formulations with (G2, DHP107, Table 3) or without Tween 80 (G7) were prepared. Pharmacokinetic profiles were different for these two formulations (Figure 4G). When the formulation without Tween 80 was administered, Tmax was 1 h instead of 3, and the AUC value was reduced to 6.3 μg·h /ml, which was *ca*. 56 % of that for DHP107.
