**9. References**

544 New Advances in the Basic and Clinical Gastroenterology

Another test vector *v* = (3, 4, 1) is inserted into the checking system. The match results are

Vector *v* converges to two detectors, which means the decision to be referred to "do not

By setting *r* = 2 in the contiguous bit matching rule we have preserved a margin of imprecision in decision making, since we do not demand all contiguous vector codes to be equal. This gives a certain chance of operating for the patients whose mix of biological

The method of making medical decisions by means of immunological systems is an applicable novelty. The example has a more didactic and experimental meaning than a real medical investigation. If we really want to use the method for making decisions in the surgery discipline we should, at first, extend the length of data strings by introducing more biological markers. A very dense set of initial vectors from "self" ("operate") ought to be chosen by the algorithm belonging to Section 4. Nevertheless, the proposal of combining fuzzy systems and weighted characteristics of vectors with the NS algorithm to create the

In the process of creation of a new medical application model we have inserted some elements of fuzzy systems into the negative selection immunological algorithm. This hybrid, attached to two disciplines of Computational Intelligence, has found a practical application in surgery decision making. As self and non-self constitute two regions of the NS partition of objects then we could identify these regions with decisions "operate" against "do not operate" in the case of curing gastric cancer patients. The action of the modified NS could help us to determine the surgery or its lack for individual patients with respect to their

To make the action of the NS algorithm more efficient we have complemented the method by preparing the population of the most representative vectors standing for the "operate" type. The vectors have been converted to real values giving the common characteristics of a patient. In that characteristics the weights of importance, assigned to biological markers, will play the

We wish to add that the excerpts from fuzzy systems, involved in NS, come from own research, which has been concentrated on the creation of compact parametric formulas. These formulas concern the generation of a family of membership functions without

All parts of the methodology have been prepared in the form of numerical algorithms given by flow charts. This allows composing a common computer program to test large samples of

essential role in the final judgment of the vectors' influence on the decision "operate".

indices cannot be precisely judged. For *r* = 3 the decision will be quite strict.

hybrid can start a new applied domain in medicine.

shown as

operate".

**7. Conclusion** 

clinical data entry vectors.

predetermining their borders in advance.

vectors in a real clinical application.

match((4, 3, 1), (3, 4, 1)) is false, match((2, 3, 4), (3, 4, 1)) is false, match((4, 4, 1), (3, 4, 1)) is true, match((3, 4, 0), (3, 4, 1)) is true.


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