**Chronic NSAIDs Therapy and Upper Gastrointestinal Tract – Mechanism of Injury, Mucosal Defense, Risk Factors for Complication Development and Clinical Management**

Francesco Azzaroli\*, Andrea Lisotti, Claudio Calvanese, Laura Turco and Giuseppe Mazzella *Department of Clinical Medicine, St. Orsola-Malpighi Hospital, University of Bologna, Bologna Italy* 
