**7. Conclusion**

Many studies on magnetite particles and their applications in various fields were published. This chapter has embedded a few examples, also including our own studies on modified magnetite particles with different fictionalizations, specific for the desired application. We emphasized the two different methods that can be employed for core-shell particles preparation. The results obtained by our group point that free-solvent technique is the more versatile one, allowing to obtain particles with smaller sizes and higher stability in magnetic fluids, important characteristics for biomedical applications. These materials are very promising for the immobilization of biologically active compounds.

### **8. Acknowledgment**

This chapter was supported by the Project financed from STRUCTURAL FUNDS within the framework of the Sectorial Operational Programme "Increasing of the Economic Competitiveness", Priority Axis 2 – Operation 2.2.1. – Developing the existing R&D infrastructure and creating a new R&D infrastructure.

#### **9. References**

170 Materials Science and Technology

Fig. 15. High-resolution C 1s, Fe 2p, O 1s and Si 2p spectra for Ma-PDMSgPEO-COOH from

Many studies on magnetite particles and their applications in various fields were published. This chapter has embedded a few examples, also including our own studies on modified magnetite particles with different fictionalizations, specific for the desired application. We emphasized the two different methods that can be employed for core-shell particles preparation. The results obtained by our group point that free-solvent technique is the more versatile one, allowing to obtain particles with smaller sizes and higher stability in magnetic fluids, important characteristics for biomedical applications. These materials are very

This chapter was supported by the Project financed from STRUCTURAL FUNDS within the framework of the Sectorial Operational Programme "Increasing of the Economic Competitiveness", Priority Axis 2 – Operation 2.2.1. – Developing the existing R&D

promising for the immobilization of biologically active compounds.

infrastructure and creating a new R&D infrastructure.

Table 2.

**7. Conclusion** 

**8. Acknowledgment** 


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**8** 

*1Italy 2Germany* 

**Carbon Nanotubes – Imprinted Polymers:** 

*1Department of Pharmaceutical Sciences, University of Calabria, Rende (CS), 2Leibniz Institute for Solid State and Materials Research Dresden, Dresden* 

Molecular imprinting is a recent new and rapidly evolving technique which allows the creation of synthetic receptors (MIPs) consisting of highly cross-linked porous-rich polymers with recognition properties comparable to the biological systems related to the presence of specific recognition sites complementary in shape, size and functional groups to a target molecule. It is a facile concept, which involves the construction of sites of specific recognition, commonly within synthetic polymers. The template of choice is entrapped within a pre-polymerization complex, consisting of functional monomers with good functionality, which chemically interacts with the template. Polymerization in the presence of crosslinker serves to freeze these template-monomer interactions and subsequent removal of the template results in the formation of a molecularly imprinted polymer matrix. Due to the advantages of MIPs such as low cost, stability, and easy preparation compared with natural molecular recognition products (e.g. antibody), Molecular imprinting is a welldeveloped tool in the analytical field, mainly for separating and quantifying very different substances, including drugs and bio-active molecules contained in relatively complex matrices. Despite the application of MIPs as sensor matrices or separation materials, they suffer from basic limitations associated with the limited concentration of imprinted sites, and the bulk volume of the polymer matrices that requires long diffusion paths of the imprinted host molecules. These limitations lead to inefficient sensing or separation processes. MIP nanomaterials are proposed as a pain reliever for headache by improving the accessibility and the homogeneity of the binding sites. In particular, with high strength, the extremely large surface area and unique chemical properties, Carbon nanotubes (CNTs) could serve as the reinforcing element or core in fabricating core–shell structural MIPs.

Since their discovery in 1991, CNTs have attracted great attention because of their unique properties (high electrical conductivity, chemical stability, mechanical strength, large specific surface area, and high thermal stability) indicating potential for various

**1. Introduction** 

applications.

Giuseppe Cirillo1\*, Silke Hampel2, Francesco Puoci1, Diana Haase2, Manfred Ritschel2, Albrecht Leonhardt2,

Francesca Iemma1 and Nevio Picci1

**Hybrid Materials for Analytical Applications** 
