**5. References**


**Isoform Features AF-1 DBD LBD AF-2** 

**ERβ1** Wild type form + + + +

Does not bind ligand + + + -

Does not bind ligand + + + -

Does not bind ligand + + + -

Does not bind ligand + + + -

and ligand independent activities - + - +

and ligand independent activities - + - +

This research was partially funded by the Graduate School of Voeding, Levensmiddelentechnologie, Agrobiotechnologie en Gezondheid (VLAG) (project number

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**ERβ2** Dimerizes with ERβ1 and ER<sup>α</sup>

**ERβ4** Dimerizes with ERβ1 and ER<sup>α</sup>

**ERβ5** Dimerizes with ERβ1 and ER<sup>α</sup>

**ERβΔ1,2,5** Reduced both ligand-dependent

**ERβΔ1,2,5,6** Reduced both ligand-dependent

Table 5. Summary of ERβ mechanism.

**4. Acknowledgements** 

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**ERβΔ5** Negative effect on ERβ1 and ERα + +

**ERβ3** Dimerizes with ERβ<sup>1</sup>


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