**6.3 Inhibition of** *LL***-DAP-AT**

A number of potential *LL*-DAP-AT inhibitors have been synthesised and characterised. In a screen involving 29,201 molecules, 15 compounds displayed IC50 values ranging from 20 µM to 60 µM, with the best hit being an aryl hydrazide showing an IC50 of 5 µM (Fan et al., 2010). However, the best hit appears to be an uncompetitive inhibitor and probably reacts irreversibly with PLP. Analogues of this compound have been synthesised and studies show that they fail to effectively inhibit *LL*-DAP-AT. In addition, there are two rhodanine-based molecules reported that show IC50 values of 41 µM and 46 µM (Fan et al., 2010).
