**Meet the editor**

Dr Luca Gallelli obtained is first honour degree in Medicine and Surgery in 1997, Ph.D in in Pharmacology and Toxycology (Chemiotherapy) in 2001and Specialization in Clinical Pharmacology in 2005. He obtained a Grant for foreign country stay by SIF (Italian Society of Pharmacology) in 2000. From 2007 he is teaching Pharmacology nurse and medicine students and stu-

dents which are specializing in Pharmacology, Respiratory Medicine and Forensic Medicine. Luca Gallelli has published 60 original research articles in international journals. He has also presented several papers in national and international symposia. He is a member of Italian Society of Pharmacology. Finally, he is referee for several international journal.

Contents

**Preface XI** 

**Part 1 Pharmacodynamic 1** 

Chapter 1 **Metabotropic Receptors for Glutamate and GABA 3**  Gregory Stewart, Julie Kniazeff, Laurent Prézeau, Philippe Rondard, Jean-Philippe Pin and Cyril Goudet

> **TRPV1 Involved in Nociceptive Processing at Peripheral Endings of Primary Afferent Fibers 43**

**Nucleotide HIV-1 Reverse Transcriptase Inhibitors 63** 

Chapter 2 **Interactions Between Glutamate Receptors and** 

You-Hong Jin, Motohide Takemura, Akira Furuyama and Norifumi Yonehara

Chapter 3 **Molecular Pharmacology of Nucleoside and** 

Chapter 4 **Opioid Kappa Receptor Selective Agonist** 

Esperanza Recio-Pinto

**Part 2 Experimental Study 141** 

Krzysztof Bryniarski

Brian D. Herman and Nicolas Sluis-Cremer

**TRK-820 (Nalfurafine Hydrochloride) 81**  Hideaki Fujii, Shigeto Hirayama and Hiroshi Nagase

**Alpha (PPAR) Agonists: A Potential Tool for a** 

**Immune Function of Murine Macrophages 143** 

Chapter 5 **The Cannabinoid 1 Receptor and Progenitor Cells in the Adult Central Nervous System 99**  Alexandra Sideris, Thomas Blanck and

Chapter 6 **Peroxisome Proliferator Activated Receptor** 

**Healthy Aging Brain 123**  Jennifer Tremblay-Mercier

Chapter 7 **The Influence of Cyclophosphamide on** 
