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We thank the interviewees for their hospitality, help, and mainly for providing us with information for the purpose of this study in the city of Diadema – São Paulo - Brazil. We are grateful to Julino Assunção Rodrigues Soares Neto and Valéria Basti. We also appreciate the help of FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), FIC (Faculdade Integral Cantareira), AFIP (Associação Fundo de Incentivo à Psicofarmacologia), FUNDUNESP (Fundação para o Desenvolvimento da UNESP) and Herbário Municipal de São Paulo (PMSP), which provided financial support which made this research possible. We thank Dr. Lúcia Rossi and Prof. Dr. Hussam El Dine Zaher, for conducting the botanical and animal identification, respectively. Finally, we really like to thank Prof. Eliana Rodrigues and Prof. Marcus Vinicius Domingues for their participation and orientation. Retracted

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**23** 

*Cuba* 

**Unconventional Raw Natural** 

**Sustainable Sources for Obtaining** 

**Active on CNS Through Catalytic,** 

Yanier Nuñez Figueredo1, Juan E. Tacoronte Morales2, Alicia Lagarto Parra1, Olinka Tiomno Tiomnova2, Jorge Tobella Sabater3 and Jorge Leyva Simeon2 *1Center for Research and Development of Pharmaceuticals,* 

*3Pharmaceutical Laboratories MEDSOL, La Lisa, Ciudad Habana,* 

**Ecologically Clean, Processes** 

*CIDEM, Cerro, Ciudad Habana,* 

**Pharmacological Principles Potentially** 

*2Center for Engineering and Chemical Researches, CIIQ, Cerro, Ciudad Habana* 

Natural products have been the most successful source of drugs ever (Tulp & Bohlin, 2005). Historically, the most important natural sources have been plants. Research progressed along two mayor lines: ethnopharmacology and toxicology. These strategies have produced many valuable drugs and are likely to continue to produce hit-lead compounds. However, actually exist numerous unconventional natural sources, ecologically sustainable, of

The development of pharmaceutical and fine chemistry in Cuba and the synthetic or natural product-oriented generation of new pharmacological and molecular entities, in the II decade of XXI century, it´s sustained in several basic conceptual and methodological principles:

 Structure (including isosteric perception) of compounds generates and define properties, which in their order, determinate application and functionality in the related

 Chemical bioprospecting of the Cuban biodiversity oriented to discovery of new *ecological* molecular fragments-templates with interesting pharmacological properties for their application in therapeutical treatments of several pathologies of CNS including

 Sustainability – Scalability (scaling-up facilities) –Applicability in real time (SSA-rt) Maximum of atomic efficiency (*click* and *green* chemistry); maximum of analytical

efficiency and maximum of environmental efficiency (MAE3)

neuroprotection, neuroregeneration after stroke and ischemia.

**1. Introduction** 

potentially medicinal compounds without research.

chemical-pharmacological space (SPAF)

Zheng, Y.Y.; Yang, J.; Chen, D.H. & Sun, L. (2007). Effects of the stilbene extracts from Cajanus cajan L. on ovariectomy-induced bone loss in rats. *Yao Xue Xue Bao*, vol. 42, pp.562-565.
