**5.2.1 General treatment for anterior epistaxis**

If the bleeding site is identified, it is recommended to use pledgets impregnated with decongestant containing bosmin or phenylephrine solution. Compress both nasal dorsum directly for at least 5 minutes after packing the nasal cavity with gauzes impregnated with decongestant and anesthetic agent.

In cases with coagulopathy, packing with pledget can damage the mucosa so hemostatic agents such as Avitene, Surgicel or gelfoam can be used. Electric cautery should be performed carefully because it can damage surrounding normal tissue. Also, physician should keep in mind that electric cautery on bilateral septum can lead to septal perforation.

In case epistaxis continues with former treatments, nasal packing using gauze with Vaseline and antibiotics, from posterior to anterior and from inferior to superior, should be done. Using bayonet forceps, grasp the packing about 10 cm from one end and place into the back of the nose. Loops of the packing are then placed one on top of another, gently but firmly pressing the loop onto the floor of the nose as each is placed. In this way, the pack is built up sequentially. The final pack should tightly fill the nasal cavity. (Figure 3)

Fig. 3. Placement of traditional or standard anterior nasal packing. A. The gauze is grasped 10cm from one end and placed into the posterior choanae. B. The gauze is layered one length at a time to build up the pack. (Cho, 2009 )

Instead of gauze, compressed sponge (Merocel) can be used. The pack is introduced in a dehydrated state and is expanded by either instilling saline or by absorbing blood from the patient. As the material expands, it fills the nasal or sinus cavity, helping to stop the bleeding in two ways: by applying pressure against the mucosa and by providing a surface against which the blood can clot.

Epistaxis 35

After placing the posterior pack, the patient should be observed in a monitored bed with saturation monitoring. For the entire time that the posterior pack is in place, humidified oxygen should be administered to prevent drying of the pharynx. Intravenous antibiotics are prescribed to prevent sinus infection and to prevent toxic shock syndrome. The pack is

A B

C D

Fig. 4. A Gauze sponge posterior packing method. A. Insertion of a nelaton catheter into nasal cavity. Pull the catheter from oropharynx to take out the tip through oral cavity. Tie the two 2- 0 silk with nelaton tip. B. Pull the nelaton catheter from nasal cavity to place the posterior pack in posterior choana. Hold the 2-0 silk which were tied to nelaton on nostril and do the anterior packing. C. Place a gauze roll in front of nostril and tie up the 2-0 silk on the gauze roll. D.

Sagittal picture with anterior and posterior nasal packing in situ. (Cho, 2009 )

normally kept in place for 3 to 5 days and then gradually deflated.

The packs are maintained for a period of 2 to 5 days depending on the circumstances. The patient can be sent home with an anterior pack in the nose. It is recommended to coat sponge with antistaphyloccocal ointment to prevent toxic shock syndrome, which is a side effect of prolonged packing. It is advisable to prescribe antistaphylococcal antibiotics for the duration of time the pack is in place for same reason. The patient should be advised to restrict activity. Absolute bed rest is not necessary, but the patient should avoid strenuous activity and should not attempt to maintain normal activity levels.

#### **5.2.2 General treatment for posterior epistaxis**

If posterior epistaxis does not stop with anterior packing, balloon insertion or posterior packing should be done. Posterior epistaxis is typically heavy and cannot be controlled with an anterior pack or by anterior compression of the nose. Posterior packing is the traditional first-line therapy for posterior epistaxis. However, with the many options available today, many otolaryngologists prefer not to use the traditional posterior pack.

The benefits of the posterior pack are that, if properly placed, this method almost always results in control of the bleeding. Also, it can be created with minimal supplies available in all emergency rooms and on all nursing units. However, there are significant disadvantages to this method. The most important is that it is very uncomfortable to place as well as to maintain for any length of time. And these packs tend to cause significant injury to the nasal mucosa. Ulcerations are common and abrasions are universal. Finally, there is a significant risk for development of hypoxia with this pack. Nasal pulmonary reflex is suspected to be the cause of unexplained hypoxia, but it is still controversial.

Several methods can be used for posterior packing. First is the foley catheter technique. With the foley catheter technique, catheter is placed through each side of the nose, grasped in the pharynx, and brought out through the mouth. Inflate the balloon with 3~4 ml of water or air and then withdraw through the nose pulling the balloon into the nasopharynx. The size of the posterior pack should be enough to fill up the posterior choana. A full anterior pack is placed in front of the posterior pack and is then fixed with umbilical clamp over the anterior nasal spine. It is important to put a soft dressing to prevent necrosis on columella.

Second method is a gauze sponge method. A gauze sponge can be rolled, tied up and is moistened with antibiotics ointment and iodine solution before use. Before placing a traditional posterior nasal pack, the patient should be well decongested and anesthetized on nasal cavity and pharynx. The gauze is tied with 2-0 silk to make two strings on one side and with 3-0 silk to make a string on the other side, and use 3-0 silk string when removing the posterior pack. The nelaton catheter is placed through nose, visualized in pharynx and brought out through the mouth. One 2-0 silk string tied to the pack is tied to the catheter and pull the catheter and 2-0 silk string from anterior nostril and place the posterior pack in posterior choana with finger tip at the same time. A full anterior pack is placed in front of the posterior pack and the 2-0 silk string through the nose is pulled tight to add the desired pressure and is the tied around the gauze bolster over the anterior nasal spine to protect the columella from pressure necrosis. (Figure 4) The anterior pack is partially removed start from the third day and the posterior pack is removed via oral cavity on fifth day.

The packs are maintained for a period of 2 to 5 days depending on the circumstances. The patient can be sent home with an anterior pack in the nose. It is recommended to coat sponge with antistaphyloccocal ointment to prevent toxic shock syndrome, which is a side effect of prolonged packing. It is advisable to prescribe antistaphylococcal antibiotics for the duration of time the pack is in place for same reason. The patient should be advised to restrict activity. Absolute bed rest is not necessary, but the patient should avoid strenuous

If posterior epistaxis does not stop with anterior packing, balloon insertion or posterior packing should be done. Posterior epistaxis is typically heavy and cannot be controlled with an anterior pack or by anterior compression of the nose. Posterior packing is the traditional first-line therapy for posterior epistaxis. However, with the many options available today,

The benefits of the posterior pack are that, if properly placed, this method almost always results in control of the bleeding. Also, it can be created with minimal supplies available in all emergency rooms and on all nursing units. However, there are significant disadvantages to this method. The most important is that it is very uncomfortable to place as well as to maintain for any length of time. And these packs tend to cause significant injury to the nasal mucosa. Ulcerations are common and abrasions are universal. Finally, there is a significant risk for development of hypoxia with this pack. Nasal pulmonary reflex is suspected to be

Several methods can be used for posterior packing. First is the foley catheter technique. With the foley catheter technique, catheter is placed through each side of the nose, grasped in the pharynx, and brought out through the mouth. Inflate the balloon with 3~4 ml of water or air and then withdraw through the nose pulling the balloon into the nasopharynx. The size of the posterior pack should be enough to fill up the posterior choana. A full anterior pack is placed in front of the posterior pack and is then fixed with umbilical clamp over the anterior

Second method is a gauze sponge method. A gauze sponge can be rolled, tied up and is moistened with antibiotics ointment and iodine solution before use. Before placing a traditional posterior nasal pack, the patient should be well decongested and anesthetized on nasal cavity and pharynx. The gauze is tied with 2-0 silk to make two strings on one side and with 3-0 silk to make a string on the other side, and use 3-0 silk string when removing the posterior pack. The nelaton catheter is placed through nose, visualized in pharynx and brought out through the mouth. One 2-0 silk string tied to the pack is tied to the catheter and pull the catheter and 2-0 silk string from anterior nostril and place the posterior pack in posterior choana with finger tip at the same time. A full anterior pack is placed in front of the posterior pack and the 2-0 silk string through the nose is pulled tight to add the desired pressure and is the tied around the gauze bolster over the anterior nasal spine to protect the columella from pressure necrosis. (Figure 4) The anterior pack is partially removed start from the third day and the posterior pack is removed via oral

nasal spine. It is important to put a soft dressing to prevent necrosis on columella.

activity and should not attempt to maintain normal activity levels.

many otolaryngologists prefer not to use the traditional posterior pack.

the cause of unexplained hypoxia, but it is still controversial.

cavity on fifth day.

**5.2.2 General treatment for posterior epistaxis** 

After placing the posterior pack, the patient should be observed in a monitored bed with saturation monitoring. For the entire time that the posterior pack is in place, humidified oxygen should be administered to prevent drying of the pharynx. Intravenous antibiotics are prescribed to prevent sinus infection and to prevent toxic shock syndrome. The pack is normally kept in place for 3 to 5 days and then gradually deflated.

Fig. 4. A Gauze sponge posterior packing method. A. Insertion of a nelaton catheter into nasal cavity. Pull the catheter from oropharynx to take out the tip through oral cavity. Tie the two 2- 0 silk with nelaton tip. B. Pull the nelaton catheter from nasal cavity to place the posterior pack in posterior choana. Hold the 2-0 silk which were tied to nelaton on nostril and do the anterior packing. C. Place a gauze roll in front of nostril and tie up the 2-0 silk on the gauze roll. D. Sagittal picture with anterior and posterior nasal packing in situ. (Cho, 2009 )

Epistaxis 37

Endoscopic cautery is widely used as an effective treatment method for epistaxis, as success rate is up to 89% and also, this method can reduce the rate of nasal packing and admission.

At the era before internal maxillary artery ligation via transantral approach was introduced, external carotid artery ligation was commonly used to treat intractable epistaxis. Although transantral approach for internal maxillary artery ligation attained less morbidity than external carotid artery ligation, it still has had weak points. Transantral approach showed high failure rate as it cannot identify the divergences of internal maxillary artery and had several complication that cannot be bypassed, such as infraorbital nerve paresthesia,

This procedure is the traditional procedure of choice for controlling posterior epistaxis. When comparing this procedure traditional posterior packing for posterior epistaxis in terms of cost-effectiveness and length of hospitalization, surgical procedure was superior to the packing. Nevertheless, most patients would prefer not to have a surgical procedure, and

Under general anesthesia, the sublabial incison is made with a No. 15 scalpel through the mucosa. The incision is located 5mm above the gingivolabial sulcus and extends from the midline to the first molar. The periosteum is incised and a subperiosteal elevation is performed over the anterior wall of the maxillary sinus. The maxillary sinus is entered over the canine fossa using a 4mm osteotome and mallet. The opening is enlarged with a Kerrison rongeur. The opening should be maximized by removing the anterior wall medially to the medial buttress, laterally to the lateral wall, inferiorly to the floor of the sinus, and superiorly to the infraorbital nerve. Then, maxillary posterior wall is drilled or removed with chisel. The initial bone removal of the posterior wall should start 1 to 2 cm below the floor of the orbit. A 4mm osteotome can be used in a controlled fashion with very light taps to fracture the thin bone of this area. Incision is made on periosteum after cauterization with a bayonet type bipolar forceps in a cruciate fashion. vessels in pterygopalatine fossa is divided and proximal vessel and distal vessels, such as sphenopalatine artery and descending palatine artery, are double ligated using hemoclips. The anatomy of the vessel is somewhat variable. However, there are several branches that can usually be identified, including the descending palatine, the superior alveolar, the infraorbital, and the sphenopalatine. Nasal packing materials are removed after the procedure and the nose is suctioned. Sinus packing with strip gauze is performed and the

This method has a high probability of failure because of anatomic variation in arterial positions. Recurrent bleeding is possible but unusual after this operation. The primary cause of rebleeding is misdiagnosis of the source of bleeding, the other cause is failure to ligate the appropriate vessels. The problem in the case of rebleeding is that it is difficult to distinguish between these two possibilities based on examination or history. In the case of rebleeding after transantral ligation of the sphenopalatine vessel, the recommended management is to

oroantraol fistula, teeth injury, sinusitis or rarely blindness.

**5.4.1 Transantral ligation of the internal maxillary artery** 

the morbidity of the transantral procedure is significant.

sublabial incision is then closed using interrupted 3-0 Vicryl suture.

**5.4 Arterial ligation** 

#### **5.3 Cautery**

Cauterization is an effective and simple way of controlling epistaxis. There are currently two methods of applying cautery in the nose. The first is the use of chemical agent, such as silver nitrate and is primarily applicable to anterior epistaxis. The second is electrocautery, which can be used throughout the nose.

#### **5.3.1 Chemical cautery**

Usually silver nitrate is used for chemical cautery. The most convenient and usual method of delivery is via a silver nitrate applicator stick. When touched to the mucosa, this causes a chemical burn that coagulates the tissue. This method should be applied to selected cases of epistaxis from the small superficial vessels. The best indication for use of silver nitrate is for active bleeding from an anterior nasoseptal vessel. The depth of coagulation is both an advantage and a limitation of this technique. The advantage is that there is minimal tissue damage and, therefore, minimal discomfort and rapid healing. The limitation is that only superficial, small vessels can be coagulated.

For chemical cauterization, the nose is first decongested and anesthetized with topical anesthesia. For actively bleeding vessels, one or two sticks are pressed against the vessel and slowly rolled to release the chemical. A piece of moistened cotton is then pressed over the area, pushing the sticks onto the vessel. After 15 to 30 seconds, the cotton and sticks are removed and the area of the cautery should be reinforced with Gelfoam or other suitable packing.

#### **5.3.2 Endoscopic cautery**

Endoscopic cauterization is rising as a valuable management tool for intractable epistaxis. Posterior endoscopic cauterization can replace arterial ligation method in many cases. Endoscopic cautery is indicated for controlling posterior epistaxis and epistaxis that stems from the septum and lateral wall, both of which lie beyond the reach of a silver nitrate stick. This procedure is very effective if the exact location of the bleeding vessel is known or the bleeding is active at the time of the procedure. The result of endoscopic cautery is largely dependent upon the experience on sinus endoscopy of the surgeon. To cauterize the bleeding on lateral wall of nasal cavity, a greater palatine block is needed to minimize the pain. In case of severe posterior epistaxis, cauterization in operating room under general anesthesia is recommended for safety.

The nose is examined using a 0-degree or 30-degree to find the bleeding focus. When doing this, use of decongestant should be avoided, as the agent can stop bleeding temporarily. If the bleeding focus is not found, it is helpful to irritate suspicious site of bleeding with suction tip. Mucosal ulceration, mucosal injury, fresh blood clot or prominent blood capillaries are common findings to suspect recent bleeding. Cautery is performed on the bleeding focus using a suction cautery unit with the power of 15 to 20 watt. If a suction cautery is not equipped, monopolar cautery is used after cover all raw surface of suction except tip with insulating tape. Although nasal packing is usually not necessary, decision is made by the surgeon after consideration of the amount of bleeding and the status of patients.

Cauterization is an effective and simple way of controlling epistaxis. There are currently two methods of applying cautery in the nose. The first is the use of chemical agent, such as silver nitrate and is primarily applicable to anterior epistaxis. The second is electrocautery, which

Usually silver nitrate is used for chemical cautery. The most convenient and usual method of delivery is via a silver nitrate applicator stick. When touched to the mucosa, this causes a chemical burn that coagulates the tissue. This method should be applied to selected cases of epistaxis from the small superficial vessels. The best indication for use of silver nitrate is for active bleeding from an anterior nasoseptal vessel. The depth of coagulation is both an advantage and a limitation of this technique. The advantage is that there is minimal tissue damage and, therefore, minimal discomfort and rapid healing. The limitation is that only

For chemical cauterization, the nose is first decongested and anesthetized with topical anesthesia. For actively bleeding vessels, one or two sticks are pressed against the vessel and slowly rolled to release the chemical. A piece of moistened cotton is then pressed over the area, pushing the sticks onto the vessel. After 15 to 30 seconds, the cotton and sticks are removed and the area of the cautery should be reinforced with Gelfoam or other suitable

Endoscopic cauterization is rising as a valuable management tool for intractable epistaxis. Posterior endoscopic cauterization can replace arterial ligation method in many cases. Endoscopic cautery is indicated for controlling posterior epistaxis and epistaxis that stems from the septum and lateral wall, both of which lie beyond the reach of a silver nitrate stick. This procedure is very effective if the exact location of the bleeding vessel is known or the bleeding is active at the time of the procedure. The result of endoscopic cautery is largely dependent upon the experience on sinus endoscopy of the surgeon. To cauterize the bleeding on lateral wall of nasal cavity, a greater palatine block is needed to minimize the pain. In case of severe posterior epistaxis, cauterization in operating room under general

The nose is examined using a 0-degree or 30-degree to find the bleeding focus. When doing this, use of decongestant should be avoided, as the agent can stop bleeding temporarily. If the bleeding focus is not found, it is helpful to irritate suspicious site of bleeding with suction tip. Mucosal ulceration, mucosal injury, fresh blood clot or prominent blood capillaries are common findings to suspect recent bleeding. Cautery is performed on the bleeding focus using a suction cautery unit with the power of 15 to 20 watt. If a suction cautery is not equipped, monopolar cautery is used after cover all raw surface of suction except tip with insulating tape. Although nasal packing is usually not necessary, decision is made by the surgeon after consideration of the amount of bleeding and the status of

**5.3 Cautery** 

packing.

patients.

**5.3.2 Endoscopic cautery** 

anesthesia is recommended for safety.

can be used throughout the nose.

superficial, small vessels can be coagulated.

**5.3.1 Chemical cautery** 

Endoscopic cautery is widely used as an effective treatment method for epistaxis, as success rate is up to 89% and also, this method can reduce the rate of nasal packing and admission.

#### **5.4 Arterial ligation**

At the era before internal maxillary artery ligation via transantral approach was introduced, external carotid artery ligation was commonly used to treat intractable epistaxis. Although transantral approach for internal maxillary artery ligation attained less morbidity than external carotid artery ligation, it still has had weak points. Transantral approach showed high failure rate as it cannot identify the divergences of internal maxillary artery and had several complication that cannot be bypassed, such as infraorbital nerve paresthesia, oroantraol fistula, teeth injury, sinusitis or rarely blindness.

#### **5.4.1 Transantral ligation of the internal maxillary artery**

This procedure is the traditional procedure of choice for controlling posterior epistaxis. When comparing this procedure traditional posterior packing for posterior epistaxis in terms of cost-effectiveness and length of hospitalization, surgical procedure was superior to the packing. Nevertheless, most patients would prefer not to have a surgical procedure, and the morbidity of the transantral procedure is significant.

Under general anesthesia, the sublabial incison is made with a No. 15 scalpel through the mucosa. The incision is located 5mm above the gingivolabial sulcus and extends from the midline to the first molar. The periosteum is incised and a subperiosteal elevation is performed over the anterior wall of the maxillary sinus. The maxillary sinus is entered over the canine fossa using a 4mm osteotome and mallet. The opening is enlarged with a Kerrison rongeur. The opening should be maximized by removing the anterior wall medially to the medial buttress, laterally to the lateral wall, inferiorly to the floor of the sinus, and superiorly to the infraorbital nerve. Then, maxillary posterior wall is drilled or removed with chisel. The initial bone removal of the posterior wall should start 1 to 2 cm below the floor of the orbit. A 4mm osteotome can be used in a controlled fashion with very light taps to fracture the thin bone of this area. Incision is made on periosteum after cauterization with a bayonet type bipolar forceps in a cruciate fashion. vessels in pterygopalatine fossa is divided and proximal vessel and distal vessels, such as sphenopalatine artery and descending palatine artery, are double ligated using hemoclips. The anatomy of the vessel is somewhat variable. However, there are several branches that can usually be identified, including the descending palatine, the superior alveolar, the infraorbital, and the sphenopalatine. Nasal packing materials are removed after the procedure and the nose is suctioned. Sinus packing with strip gauze is performed and the sublabial incision is then closed using interrupted 3-0 Vicryl suture.

This method has a high probability of failure because of anatomic variation in arterial positions. Recurrent bleeding is possible but unusual after this operation. The primary cause of rebleeding is misdiagnosis of the source of bleeding, the other cause is failure to ligate the appropriate vessels. The problem in the case of rebleeding is that it is difficult to distinguish between these two possibilities based on examination or history. In the case of rebleeding after transantral ligation of the sphenopalatine vessel, the recommended management is to

Epistaxis 39

General anesthesia is achieved with orotracheal intubation. Before the nasal pack is removed, a transpalatal injection of the greater palatine foramen is performed using local anesthetic agent to minimize the bleeding after removal of the posterior pack. After removal of posterior pack, using 0 degree endoscope, thorough suction in the nasal cavity is performed for visualization. The posterior attachment of the middle turbinate is identified and an incision is made in the mucosa about 1 cm anterior to this point, extending from the inferior turbinate to the ethmoid sinus. The mucoperiosteal flap is elevated posterosuperiorly then surgeon can identify bundle of vessels and nerves originated from sphenopalatine foramen. The vessels are then carefully dissected with Freer elevator to identify sphenopalatine artery and ligation of the artery with surgical clip is performed. The mucoperiosteal flap is then repositioned and the procedure is concluded simply by placing a

Fig. 5. Endoscopic ligation of sphenopalatine artery. Left side. A.The mucosa immediately posterior to the attachment of the middle turbinate is elevated to expose the branches of the sphenopalatine artery. B. The bone of the sphenopalatine foramen is removed to expose the main artery. C. The artery and its main branches are ligated with microclips. D. The mucosal flap is covered for the last step of the surgery. (Snyderman & Carau, 1997) MT; middle

turbinate, IT; inferior turbinate, ST; superior turbinate.

Surgicel on the incision site.

perform an arteriogram. This will reliably distinguish between these situations, and also affords the option of embolization if amenable.

#### **5.4.2 External ligation of the ethmoid artery**

Epistaxis from anterior ethmoid artery is rare, however, trauma patients with fractures through the skull base that avulse or lacerate the anterior ethmoid artery can occur. Anterior ethmoid artery ligation via external approach is usually used in cases of epistaxis after facial trauma. Also, following endoscopic sinus surgery, some patients may develop heavy bleeding from the anterior or posterior ethmoid arteries that may not respond to packing. These can be treated with endoscopic cautery in most of cases. In certain cases, it may be preferable to ligate the vessel. Finally, patients with HHT may require vessel ligation to minimize the frequency or severity of epistaxis.

Under general anesthesia, operation starts with incision. In most cases, the nose is packed and there may be a posterior pack or nasal balloon. If possible, it is best to leave this in place until after the procedure is finished. Lynch incision is made on epistaxis side and the subcutaneous tissue is divided down through the periosteum to the bone. The angular artery will be encountered in the inferior aspect of the wound and should be controlled with either ligation or bipolar cautery. The soft tissues are retracted and the eye is elevated from the orbital bone with a Freer elevator. Lacrimal fossa and frontoethmoidal suture line can be identified. While advancing posteriorly along the frontoethmoid suture line, anterior ethmoid artery is found 20 to 24 mm posterior to the anterior lacrimal crest and this should be double ligated or cauterized. The preferred technique is to use bipolar cautery, as the clips tend to fall off and can lead to orbital hematoma. It is important to make sure that the full diameter of the artery is cauterized. Once the artery is fully cauterized or clipped, Jameson scissors are used to transect the artery in the middle, making sure that there is room to cauterize each stump if necessary. The dissection is then carried posteriorly for another 10 to 12mm until reaching the posterior ethmoid artery. Posterior ethmoid artery goes close to optic nerve and is not a major vessel that causes epistaxis, so ligation is usually not considered. After the arteries are divided, the wound is closed. Hemostasis should be achieved using bipolar cautery on the orbital tissues and monopolar cautery on the subcutaneous tissues.

All patients should be observed at least overnight after this surgery for two significant concerns: orbital hematoma and rebleeding. Orbital edema and ecchymosis are expected. However, there should not be any chemosis, true proptosis, or limitation of extraocular movements. Any of these signs suggests orbital hematoma and should be managed immediately according to the management protocol for orbital hematoma.

#### **5.4.3 Endoscopic ligation of sphenopalatine artery**

Endoscopic ligation of the internal maxillary artery is the newest addition to the surgical arsenal of the rhinologist for posterior epistaxis that can lower the complication of transantral approach and pterygomaxillary fossa dissection, and can prevent the collateral vessel formation as the most distal part of the artery is ligated, compared to other methods.

perform an arteriogram. This will reliably distinguish between these situations, and also

Epistaxis from anterior ethmoid artery is rare, however, trauma patients with fractures through the skull base that avulse or lacerate the anterior ethmoid artery can occur. Anterior ethmoid artery ligation via external approach is usually used in cases of epistaxis after facial trauma. Also, following endoscopic sinus surgery, some patients may develop heavy bleeding from the anterior or posterior ethmoid arteries that may not respond to packing. These can be treated with endoscopic cautery in most of cases. In certain cases, it may be preferable to ligate the vessel. Finally, patients with HHT may require vessel ligation to

Under general anesthesia, operation starts with incision. In most cases, the nose is packed and there may be a posterior pack or nasal balloon. If possible, it is best to leave this in place until after the procedure is finished. Lynch incision is made on epistaxis side and the subcutaneous tissue is divided down through the periosteum to the bone. The angular artery will be encountered in the inferior aspect of the wound and should be controlled with either ligation or bipolar cautery. The soft tissues are retracted and the eye is elevated from the orbital bone with a Freer elevator. Lacrimal fossa and frontoethmoidal suture line can be identified. While advancing posteriorly along the frontoethmoid suture line, anterior ethmoid artery is found 20 to 24 mm posterior to the anterior lacrimal crest and this should be double ligated or cauterized. The preferred technique is to use bipolar cautery, as the clips tend to fall off and can lead to orbital hematoma. It is important to make sure that the full diameter of the artery is cauterized. Once the artery is fully cauterized or clipped, Jameson scissors are used to transect the artery in the middle, making sure that there is room to cauterize each stump if necessary. The dissection is then carried posteriorly for another 10 to 12mm until reaching the posterior ethmoid artery. Posterior ethmoid artery goes close to optic nerve and is not a major vessel that causes epistaxis, so ligation is usually not considered. After the arteries are divided, the wound is closed. Hemostasis should be achieved using bipolar cautery on the orbital tissues and monopolar cautery on the

All patients should be observed at least overnight after this surgery for two significant concerns: orbital hematoma and rebleeding. Orbital edema and ecchymosis are expected. However, there should not be any chemosis, true proptosis, or limitation of extraocular movements. Any of these signs suggests orbital hematoma and should be managed

Endoscopic ligation of the internal maxillary artery is the newest addition to the surgical arsenal of the rhinologist for posterior epistaxis that can lower the complication of transantral approach and pterygomaxillary fossa dissection, and can prevent the collateral vessel formation as the most distal part of the artery is ligated, compared to other

immediately according to the management protocol for orbital hematoma.

**5.4.3 Endoscopic ligation of sphenopalatine artery** 

affords the option of embolization if amenable.

**5.4.2 External ligation of the ethmoid artery** 

minimize the frequency or severity of epistaxis.

subcutaneous tissues.

methods.

General anesthesia is achieved with orotracheal intubation. Before the nasal pack is removed, a transpalatal injection of the greater palatine foramen is performed using local anesthetic agent to minimize the bleeding after removal of the posterior pack. After removal of posterior pack, using 0 degree endoscope, thorough suction in the nasal cavity is performed for visualization. The posterior attachment of the middle turbinate is identified and an incision is made in the mucosa about 1 cm anterior to this point, extending from the inferior turbinate to the ethmoid sinus. The mucoperiosteal flap is elevated posterosuperiorly then surgeon can identify bundle of vessels and nerves originated from sphenopalatine foramen. The vessels are then carefully dissected with Freer elevator to identify sphenopalatine artery and ligation of the artery with surgical clip is performed. The mucoperiosteal flap is then repositioned and the procedure is concluded simply by placing a Surgicel on the incision site.

Fig. 5. Endoscopic ligation of sphenopalatine artery. Left side. A.The mucosa immediately posterior to the attachment of the middle turbinate is elevated to expose the branches of the sphenopalatine artery. B. The bone of the sphenopalatine foramen is removed to expose the main artery. C. The artery and its main branches are ligated with microclips. D. The mucosal flap is covered for the last step of the surgery. (Snyderman & Carau, 1997) MT; middle turbinate, IT; inferior turbinate, ST; superior turbinate.

Epistaxis 41

Septoplasty is helpful to manage epistaxis in selected cases with severe septal deviation or septal mass. This procedure is needed in cases that bleeding focus is behind the septal spur or management approach is hindered by septal deviation. As most haemorrhages occur from the septum, raising a mucoperichondral flap during septal surgery can be beneficial as this will decrease blood flow to the mucosa, which often in itself stems bleeding. It is also performed to block the blood supply in Kiesselbach plexus, or to remove hemorrhagic nodule or septal turbinate. Surgery is also used to correct a deviated septum or remove a septal spur, which may be the cause of epistaxis. This occurs either by altering air flow through the nose or in severe cartilage deformities, by persistent mucosal irritation. As it is one of the most common procedures that are performed by rhinologists, detailed operation

Fibrin glue is developed from human plasma cryoprecipitate and binds itself to damaged vessels. The technique entails spraying a thin layer of glue over the bleeding site and can be repeated as needed. On one randomized trial has reported that complications of local swelling, nasal mucosa atrophy, and excessive nasal discharge were lower than the electrocautery, silver nitrate, and nasal packing group. The rebleed rate was 15%, which is

Hot water irrigation was first described by Guice in 1878 as an effective method of treating severe, life-threatening epistaxis. Hot water irrigation is performed in continuous posterior epistaxis cases. The affected nasal cavity is continuously irrigated during 3 minutes with 500 ml water heated to 50°C after packing the posterior choanae with balloon catheter. Tap water is administered via a water irrigator. The patient is then seated upright with their face pointed downward over a basin, to allow outflow of water from the affected nasal cavity into the basin. This method produces vasodilation and edema of the nasal mucosa without the risk of necrosis. This mucosal edema leads to local compression of the bleeding vessels, while at the same time triggering and probably accelerating the clotting cascade. (Novoa &

The management of HHT depends on several independent factors. These include the number and location of the intranasal lesions, the severity and frequency of epistaxis, the number and location of gastrointestinal, brain and pulmonary lesions, the number of blood transfusions attributable to the epistaxis, the effect of the epistaxis on the patient's quality of

Medical therapy for HHT, in addition to that outlined earlier for epistaxis in general, has focused on the use of estrogen and progesterone. This treatment was based on the

skills are not described in this chapter. (Pope & Hobbs, 2005)

comparable to electrocautery. (Pope & Hobbs, 2005)

**5.8 Management of Hereditary Hemorrhagic Telangiectasia** 

life and the previous treatments attempted.

**5.6 Septoplasty** 

**5.7 Anonymous 5.7.1 Fibrin glue** 

**5.7.2 Hot water irrigation** 

Schlegel-Wagner, 2011)

After the operation, the patient's activity should be restricted for several days. After discharge from the hospital, activity and diet are gradually returned to normal. Full activity, including exercise, should be avoided for 2 weeks after the procedure. Extreme care must be exercised when suctioning over the area of the ligation during dressing, to avoid accidentally suctioning off one of the clips. All of the complications associated with endoscopic sinus surgery are possible with this endoscopic ligation procedure, though the risks of those are lower in this setting than for routine endoscopic sinus surgery.

#### **5.4.4 External carotid artery ligation**

External carotid artery ligation is performed at site afar from nasal cavity, so rebleeding from collateral vessels from internal carotid artery or contralateral carotid artery is reported upto 45% of patients. Therefore, limited cases of epistaxis from peripheral collateral vessels from external carotid artery are indicated for external carotid artery ligation.

Horizontal incision between hyoid and superior border of thyroid cartilage is made, subplatysmal flap elevation is performed and sternocleidomastoid muscle is retracted posteriorly to visualize internal jugular vein, which is retracted to identify external carotid artery. More than two branches should be identified to confirm external carotid artery from internal carotid artery, and then external carotid artery is ligated.

#### **5.5 Arterial embolization**

One of the options for severe posterior epistaxis is intraarterial embolization. Selective arterial embolization has advantages that duration of in-hospital stay is short, procedure can be performed under local anesthesia, vessels that are laborious for surgical approach can be treated, and success rate is high in surgical failure cases of arteriovenous communication. This procedure is usually performed under local anesthesia in the arteriography suite of the hospital, a catheter is placed into the groin and threaded through the femoral artery, into the aorta, into the carotid artery and finally into the internal maxillary artery. A test injection is performed to identify the bleeding site. If there is no communication between internal maxillary artery and internal carotid artery or vertebral artery, various materials are used for embolization, including gelfoam, coils, balloons, and polyvinyl alcohol particles. Injection of the materials is repeated until blood flow at the bleeding sites decreases or stops. If bleeding have recurred short after the embolization, the source of the bleeding is anterior or posterior ethmoid artery, which are branches of internal carotid artery, so surgical approach to these vessels might be needed, and collateral vessel bleeding from facial artery is occurred, reembolization should be performed. More than half of cases of rebleeding long after the treatment are reported to be hereditary hemorrhagic telangiectasia.

Embolization is a useful and highly successful technique for controlling posterior epistaxis. However, in all large series of carotid artery catherization, there is an incidence of serious cerebrovascular accident (CVA) resulting in permanent neurologic deficit. The incidence of this varies with the skill of the radiologist in performing the procedure, with an overall average of about 4%. As it is a relatively high rate for such a major complication, the use of embolization for control of epistaxis is still controversial.

After the operation, the patient's activity should be restricted for several days. After discharge from the hospital, activity and diet are gradually returned to normal. Full activity, including exercise, should be avoided for 2 weeks after the procedure. Extreme care must be exercised when suctioning over the area of the ligation during dressing, to avoid accidentally suctioning off one of the clips. All of the complications associated with endoscopic sinus surgery are possible with this endoscopic ligation procedure, though the

External carotid artery ligation is performed at site afar from nasal cavity, so rebleeding from collateral vessels from internal carotid artery or contralateral carotid artery is reported upto 45% of patients. Therefore, limited cases of epistaxis from peripheral collateral vessels

Horizontal incision between hyoid and superior border of thyroid cartilage is made, subplatysmal flap elevation is performed and sternocleidomastoid muscle is retracted posteriorly to visualize internal jugular vein, which is retracted to identify external carotid artery. More than two branches should be identified to confirm external carotid artery from

One of the options for severe posterior epistaxis is intraarterial embolization. Selective arterial embolization has advantages that duration of in-hospital stay is short, procedure can be performed under local anesthesia, vessels that are laborious for surgical approach can be treated, and success rate is high in surgical failure cases of arteriovenous communication. This procedure is usually performed under local anesthesia in the arteriography suite of the hospital, a catheter is placed into the groin and threaded through the femoral artery, into the aorta, into the carotid artery and finally into the internal maxillary artery. A test injection is performed to identify the bleeding site. If there is no communication between internal maxillary artery and internal carotid artery or vertebral artery, various materials are used for embolization, including gelfoam, coils, balloons, and polyvinyl alcohol particles. Injection of the materials is repeated until blood flow at the bleeding sites decreases or stops. If bleeding have recurred short after the embolization, the source of the bleeding is anterior or posterior ethmoid artery, which are branches of internal carotid artery, so surgical approach to these vessels might be needed, and collateral vessel bleeding from facial artery is occurred, reembolization should be performed. More than half of cases of rebleeding long after the treatment are reported to

Embolization is a useful and highly successful technique for controlling posterior epistaxis. However, in all large series of carotid artery catherization, there is an incidence of serious cerebrovascular accident (CVA) resulting in permanent neurologic deficit. The incidence of this varies with the skill of the radiologist in performing the procedure, with an overall average of about 4%. As it is a relatively high rate for such a major complication, the use of

risks of those are lower in this setting than for routine endoscopic sinus surgery.

from external carotid artery are indicated for external carotid artery ligation.

internal carotid artery, and then external carotid artery is ligated.

**5.4.4 External carotid artery ligation** 

**5.5 Arterial embolization** 

be hereditary hemorrhagic telangiectasia.

embolization for control of epistaxis is still controversial.

#### **5.6 Septoplasty**

Septoplasty is helpful to manage epistaxis in selected cases with severe septal deviation or septal mass. This procedure is needed in cases that bleeding focus is behind the septal spur or management approach is hindered by septal deviation. As most haemorrhages occur from the septum, raising a mucoperichondral flap during septal surgery can be beneficial as this will decrease blood flow to the mucosa, which often in itself stems bleeding. It is also performed to block the blood supply in Kiesselbach plexus, or to remove hemorrhagic nodule or septal turbinate. Surgery is also used to correct a deviated septum or remove a septal spur, which may be the cause of epistaxis. This occurs either by altering air flow through the nose or in severe cartilage deformities, by persistent mucosal irritation. As it is one of the most common procedures that are performed by rhinologists, detailed operation skills are not described in this chapter. (Pope & Hobbs, 2005)

## **5.7 Anonymous**

## **5.7.1 Fibrin glue**

Fibrin glue is developed from human plasma cryoprecipitate and binds itself to damaged vessels. The technique entails spraying a thin layer of glue over the bleeding site and can be repeated as needed. On one randomized trial has reported that complications of local swelling, nasal mucosa atrophy, and excessive nasal discharge were lower than the electrocautery, silver nitrate, and nasal packing group. The rebleed rate was 15%, which is comparable to electrocautery. (Pope & Hobbs, 2005)

#### **5.7.2 Hot water irrigation**

Hot water irrigation was first described by Guice in 1878 as an effective method of treating severe, life-threatening epistaxis. Hot water irrigation is performed in continuous posterior epistaxis cases. The affected nasal cavity is continuously irrigated during 3 minutes with 500 ml water heated to 50°C after packing the posterior choanae with balloon catheter. Tap water is administered via a water irrigator. The patient is then seated upright with their face pointed downward over a basin, to allow outflow of water from the affected nasal cavity into the basin. This method produces vasodilation and edema of the nasal mucosa without the risk of necrosis. This mucosal edema leads to local compression of the bleeding vessels, while at the same time triggering and probably accelerating the clotting cascade. (Novoa & Schlegel-Wagner, 2011)

#### **5.8 Management of Hereditary Hemorrhagic Telangiectasia**

The management of HHT depends on several independent factors. These include the number and location of the intranasal lesions, the severity and frequency of epistaxis, the number and location of gastrointestinal, brain and pulmonary lesions, the number of blood transfusions attributable to the epistaxis, the effect of the epistaxis on the patient's quality of life and the previous treatments attempted.

Medical therapy for HHT, in addition to that outlined earlier for epistaxis in general, has focused on the use of estrogen and progesterone. This treatment was based on the

Epistaxis 43

angiogenesis. As a result, bevacizumab has been used as a potential treatment of recurrent epistaxis. Previous studies have demonstrated marked improvement of epistaxis with intravenous administration of bevacizumab. Intranasal treatment with bevacizumab, by either submucosal injection or topical nasal spray, has recently been reported to be a safe

Over the past decade, there has been a significant development in the options available for the management of epistaxis. Traditional strategies like nasal packing have been supplemented by modern technology using the latest optic and electrical devices. Treatment should ideally use a systematic protocol; starting with simple procedures that can be undertaken in the clinic environment and proceeding to endoscopic techniques for more

Brinkerhoff, BT, Choong, NW, Treisman, JS & Poetker, DM (2011). Intravenous and

Cho, JS (2009 ).Epistaxis. In: *Otorhinolarngology head and neck surgery*, surgery, KsoO-Han, pp.

Fuchizaki, U, Miyamori, H, Kitagawa, S, Kaneko, S & Kobayashi, K (2003). Hereditary

Guttmacher, AE, Marchuk, DA & White, RI, Jr. (1995). Hereditary hemorrhagic

Herkner, H, Laggner, AN, Mullner, M, Formanek, M, Bur, A, Gamper, G, Woisetschlager, C

*Journal of Laryngology & Otology* Vol. No., (Aug 16), pp. 1-5, ISSN 1748-5460 Novoa, E & Schlegel-Wagner, C (2011). Hot water irrigation as treatment for intractable

Pope, LE & Hobbs, CG (2005). Epistaxis: an update on current management. *Postgraduate* 

Snyderman, CH & Carau, RL (1997). Endoscopic Ligation of the Sphenopalatine Artery For

*Medical Journal* Vol. 81, No. 955, (May), pp. 309-314, ISSN 0032-5473

*Emergency Medicine* Vol. 35, No. 2, (Feb), pp. 126-130, ISSN 0196-0644 Joshi, H, Woodworth, BA & Carney, AS (2011). Coblation for epistaxis management in

1048-1057, Ilchokak, ISBN 978-89-337-0559-9, Seoul

9394, (Nov 1), pp. 1490-1494, ISSN 0140-6736

Vol. No., (Sep 5), pp. 1-3, ISSN 1748-5460

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topical intranasal bevacizumab (Avastin) in hereditary hemorrhagic telangiectasia. *American Journal of Otolaryngology* Vol. No., (Sep 12), pp., ISSN 0196-

haemorrhagic telangiectasia (Rendu-Osler-Weber disease). *The Lancet* Vol. 362, No.

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& Hirschl, MM (2000). Hypertension in patients presenting with epistaxis. *Annals of* 

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Epistaxis. *Operative Techniques in Otolaryngology Head and Neck Surgery* Vol. 8, No. 2,

alternative to intravenous treatment. (Brinkerhoff et al., 2011)

**6. Conclusion** 

difficult cases.

**7. References** 

0709

924, ISSN 0028-4793

observation that epistaxis tended to decrease during pregnancy among affected individuals. Antifibrinolytic therapy using aminocaproic acid has also been discussed. None of these medical treatments has proven effective in completely relieving epistaxis in the long term, but some benefits have been claimed.

Because of the failure of these methods, numerous other modalities have been attempted, including sclerotherapy, brachytherapy, electrocautery, arterial ligation, embolization, septodermoplasty, closure of the nasal cavities, and laser coagulation. The clear implication of all of these reports is that there remains no cure for HHT and, despite all treatment attempts, recurrent epistaxis is possible. In light of these facts, the author suggests that treatment should be designed to minimize the bleeding while avoiding complications. For this reason, extreme measures, such as brachytherapy, embolization, and invasive surgery, should be avoided.

As regards laser treatment of HHT, there is controversy over which type of laser is best. Carbon dioxide, ND:YAG, pulsed dye laser, diode and KTP lasers have all been used for this purpose, with the KTP laser now gaining consensus as the most popular device. It has been suggested that laser can easily ablate the periphery of larger lesions to reduce central blood flow, but that direct laser focused on the center of a lesion causes extensive bleeding and makes further treatment difficult. (Joshi et al., 2011)

Septodermoplasty involves removal of nasal mucosa from the anterior part of the nasal cavity and replacement by a split skin graft. This technique has been found to have good initial outcomes in patients with HHT patients, which unfortunately decline over time due to contraction and revascularization of the graft. The technique has also been found to be associated with nasal crusting and halitosis.

Closure of the nasal cavity, the so called Young's procedure is a radical technique involving closure of the nasal vestibule. Although it provides long term relief in patients with moderate to severe epistaxis secondary to HHT, the disadvantages (dry mouth, loss of smell and complete nasal obstruction) are often not tolerated by patients. Upon reviewing the procedure, Young himself found that many patients had to have the procedure reversed because of these problems. Young's procedure is best reserved for cases of HHT unresponsive to other treatment modalities.

Radiofrequency coblation is a relatively new technique which is being increasingly used in ENT surgery. Coblation has been demonstrated to promote good healing and to preserve surrounding normal tissue. Despite low temperatures, small blood vessels are sealed by this process. Radiofrequency coblation can therefore theoretically achieve both ablation and hemostasis of telangiectatic and arteriovenous malformations, using the same instrument. The use of coblation for hereditary haemorrhagic telangiectasia epistaxis is a much more conservative procedure, which can be safely repeated without significant complications. (Joshi et al., 2011)

Elevated plasma levels of vascular endothelial growth factor (VEGF) play a key pathogenic role in HHT. Bevacizumab, an anti-VEGF monoclonal antibody, prevents the binding of VEGF to VEGF receptor on endothelial cells, thus blocking cellular proliferation and

observation that epistaxis tended to decrease during pregnancy among affected individuals. Antifibrinolytic therapy using aminocaproic acid has also been discussed. None of these medical treatments has proven effective in completely relieving epistaxis in the long term,

Because of the failure of these methods, numerous other modalities have been attempted, including sclerotherapy, brachytherapy, electrocautery, arterial ligation, embolization, septodermoplasty, closure of the nasal cavities, and laser coagulation. The clear implication of all of these reports is that there remains no cure for HHT and, despite all treatment attempts, recurrent epistaxis is possible. In light of these facts, the author suggests that treatment should be designed to minimize the bleeding while avoiding complications. For this reason, extreme measures, such as brachytherapy, embolization, and invasive surgery,

As regards laser treatment of HHT, there is controversy over which type of laser is best. Carbon dioxide, ND:YAG, pulsed dye laser, diode and KTP lasers have all been used for this purpose, with the KTP laser now gaining consensus as the most popular device. It has been suggested that laser can easily ablate the periphery of larger lesions to reduce central blood flow, but that direct laser focused on the center of a lesion causes extensive bleeding and

Septodermoplasty involves removal of nasal mucosa from the anterior part of the nasal cavity and replacement by a split skin graft. This technique has been found to have good initial outcomes in patients with HHT patients, which unfortunately decline over time due to contraction and revascularization of the graft. The technique has also been found to be

Closure of the nasal cavity, the so called Young's procedure is a radical technique involving closure of the nasal vestibule. Although it provides long term relief in patients with moderate to severe epistaxis secondary to HHT, the disadvantages (dry mouth, loss of smell and complete nasal obstruction) are often not tolerated by patients. Upon reviewing the procedure, Young himself found that many patients had to have the procedure reversed because of these problems. Young's procedure is best reserved for cases of HHT

Radiofrequency coblation is a relatively new technique which is being increasingly used in ENT surgery. Coblation has been demonstrated to promote good healing and to preserve surrounding normal tissue. Despite low temperatures, small blood vessels are sealed by this process. Radiofrequency coblation can therefore theoretically achieve both ablation and hemostasis of telangiectatic and arteriovenous malformations, using the same instrument. The use of coblation for hereditary haemorrhagic telangiectasia epistaxis is a much more conservative procedure, which can be safely repeated without significant complications.

Elevated plasma levels of vascular endothelial growth factor (VEGF) play a key pathogenic role in HHT. Bevacizumab, an anti-VEGF monoclonal antibody, prevents the binding of VEGF to VEGF receptor on endothelial cells, thus blocking cellular proliferation and

but some benefits have been claimed.

makes further treatment difficult. (Joshi et al., 2011)

associated with nasal crusting and halitosis.

unresponsive to other treatment modalities.

should be avoided.

(Joshi et al., 2011)

angiogenesis. As a result, bevacizumab has been used as a potential treatment of recurrent epistaxis. Previous studies have demonstrated marked improvement of epistaxis with intravenous administration of bevacizumab. Intranasal treatment with bevacizumab, by either submucosal injection or topical nasal spray, has recently been reported to be a safe alternative to intravenous treatment. (Brinkerhoff et al., 2011)

#### **6. Conclusion**

Over the past decade, there has been a significant development in the options available for the management of epistaxis. Traditional strategies like nasal packing have been supplemented by modern technology using the latest optic and electrical devices. Treatment should ideally use a systematic protocol; starting with simple procedures that can be undertaken in the clinic environment and proceeding to endoscopic techniques for more difficult cases.

#### **7. References**


**1. Introduction** 

**2. Diagnostics** 

 \*

trigeminal sensory nerve stimulation.

**2.1 Goals of diagnostics are the following** 

approach which is usually surgical.

(PANDO) and nasal pathologies.

Corresponding Author

1. To distinguish epiphora from hyperlacrimation. 2. Determine pathological process that is the cause. 3. To distinguish anatomical and functional disorders.

**2.2 The diagnostic tests are divided into the following** 

**3** 

*Mumbai India* 

**Endoscopic Dacryocystorhinostomy** 

Chris de Souza1, Rosemarie de Souza2\* and Jayesh Nisar3 *1Lilavati Hospital, Holy Family Hospital and Tata Memorial Hospital* 

Early cases of dacryocystitis occur because of inflammation of the mucous membrane with resulting malfunction in the subepithelial cavernous body with occlusion of the lacrimal passage. Repeated attacks of dacryocystitis leads to structural epithelial changes, with loss of mucin, loss of TFF peptide producing goblet cells and columnar epithelial cells. Remodeling of the helical arrangement of the subepithelial connective tissue fibers leads to total fibrous closure. This then leads to epiphora.Primary acquired nasolacrimal duct

Two basic causes of tearing exist. Epiphora that is associated with blockage of the lacrimal system and excessive lacrimation (hyperlacrimation) which is a less common cause. Hyperlacrimation is caused by corneal irritation. Unilateral hyper lacrimation is caused by

Epiphora is tearing caused by a reduced tear transport mechanism or a defective tear

4. To evaluate the location of the block, its extent and to decide on the appropriate

a. Anatomical tests for investigation of morphological disorders and location of the site of obstruction as in punctal and canalicular pathologies, nasolacrimal duct obstruction

drainage outflow. Epiphora can on occasion be caused by a combination of both.

obstruction (PANDO) is a syndrome of unknown origin.

*2TNMC Medical College and the BYL Nair Hospital* 

*3Gala Eye Hospital and Jain Health Center* 

Viducich, RA, Blanda, MP & Gerson, LW (1995). Posterior epistaxis: clinical features and acute complications. *Annals of Emergency Medicine* Vol. 25, No. 5, (May), pp. 592- 596, ISSN 0196-0644
