**3.2 Metabolic parameters in the umbilical venous blood (tables 4 and 5, figure 1)**

The results were analysed by type of pathology and compared with the norms established for the gestational age considered.

In the reference population, the umbilical venous concentrations of the parameters studied were found to be stable during gestation, with the exception of lactate which rises physiologically (Bon et al., 2007).

The limit of normal values was set at one standard deviation more or less on either side of the mean value of the control group, except for free fatty acids and ketone bodies for which the limits were set at the 10th and 90th percentiles of the values of this group.


The results are expressed as means and standard deviations.

n = number of samples

\* p < 0.05

168 From Preconception to Postpartum

The gasometric balance shows acidemia, hypoxemia and hypercapnia, in the presence of a

A decrease in pO2 is observed in the fetus presenting a genital anomaly, whereas the pH,

One state of probably gaseous alcalosis, in the presence of a polymalformative syndrome, is

The case of chylothorax, with pleural effusion, is complicated by gaseous acidosis with

**3.1.7 Other malformations (isolated cases, n=8)** 

pCO2, and bicarbonate concentration are within the normal range.

multicystic hepatic tumour.

moderate hypoxemia.

Hepatic tumour

pH 7.19\* 7.33 7.32

(kPa) 8.56\* 5.33 5.25

(mmol/l) 23.9 21.1 19.9

(kPa) 2.74\* 7.28 7.01

SaO2 0.23\* 0.85 0.82

\* value outside the normality interval for the gestational age

Reductional

anomaly

of the limbs

Anomaly of the

extremities

n 1 1 2 1 1 1 1

Table 3. Gasometric and acid-base parameters in the umbilical venous blood (number of

Genital anomaly

Polymalformative

syndrome

7.36 7.31 7.49\* 7.25\* 7.36

6.08 5.57 3.75\* 7.24\* 5.01

25.6 20.9 21.5 23 21.3

5.91 2.97\* 5.07 3.79\* 7.08

0.79 0.33\* 0.77 0.43\* 0.86

Familial recurrent

chylothorax

Microphthalmia

found.

pCO2

HCO3-

pO2

n = number of samples

 value increased value decreased

cases 2).

\*\* p < 0.01

\*\*\* p < 0.001

Table 4. Metabolic parameters in the umbilical venous blood (number of cases 3).

Lactatemia is significantly increased in the presence of a genital anomaly (left ovarian cyst). A moderate rise in the lactate and ketone bodies UVB concentrations is observed in the case

of familial recurrent chylothorax.

Glucose

Lactate

Free fatty acids (mmol/l)

Aceto-acetate

Betahydroxybutyrate (mmol/l)

Cholesterol

 value increased value decreased

n = number of samples

Hepatic tumour Reductional

(mmol/l) 2.5\* 3.5 6.8\*

(mmol/l) 2.9\* 1.2 1.6

(mmol/l) 0.020\* 0.101 0.090

(mmol/l) 1.20 1.45 1.92

\* value outside the normality interval for the gestational age

anomaly

0.076 0.179 0.068

0.105\* 0.236 0.230

Table 5. Metabolic parameters in the umbilical venous blood (n 2).

of the limbs

Anomaly of the

extremities

n 1 1 2 1 1 1 1

Genital anomaly

Polymalformative

syndrome

7.1\* 3.6 3.7 4.0 4.6

1.7 4.3\* 1.8 2.3\* 1.5

0.135 0.087 0.117 0.113 0.134

0.098 / 0.105 0.195\* 0.110

0.284 / 0.294 0.640\* 0.470

2.34 1.43 1.82 2.17 2.43

Familial recurrent

chylothorax

Microphthalmia
