**1. Introduction**

Hypertension (HT) and cardiovascular disease (CVD) are common in dialysis-dependent chronic kidney disease (DD-CKD) patients. The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of HT in DD-CKD patients. Activated RAAS also increases inflammatory mediators, which was shown to be an independent predictor of CVD in DD-CKD patients. Recent meta-analyses suggested that antihypertensive pharmacotherapy may reduce CVD in DD-CKD patients. This review focuses on the physiological roles and blockade effects of RAAS for HT and CVD in DD-CKD patients.
