**2.1.4 Multiple organ dysfunction syndrome**

Because of the amplification of systemic inflammatory states after sepsis, without appropriate intensive care including antibiotic therapy, vasopressor medications, mechanical dialysis (Dellinger RP et al, 2008), systemic inflammatory response syndrome and cytokine storm then lead to be multiple organ dysfunction syndrome. Once sepsis is reached to multiple organ dysfunction syndrome, the patients are destined to be coma or delirium. Multiple organ dysfunction syndrome implicates in the pathogenesis of septic encephalopathy.
