**2.1 Animals**

All experimental procedures on animals were approved by the Florey Neuroscience Institutes animal ethics committee and conform to the National Health and Medical Research Council of Australia's published code of practice.

Male C57Bl/6J mice and male Sprague-Dawley rats were used for this study. Throughout the experiments all animals were housed in a climate-controlled (22oC) room on a 12/12hour light/dark cycle with ad libitum access to food (standard rodent chow) and water.
