**6. Conclusion**

In this contribution we introduced a methodological approach which appears promising for a possibility of establishing the bridge between the neurochemistry of the brain monoaminergic systems and psychophysiological measures such as skin conductance response. The SCR system in this perspective is viewed as a linear neurochemical oscillator suitable for mathematical modeling and estimation of the inherent control process. Through mathematical modeling of the SCR process two kinds of metrics emerged. One of them refers to the features of the hidden neural input for the SCR system generated in the amigdala-hippocamus interaction when an individual is encountered with an unexpected and significant stimulus. The other metrics specifies the regulatory (control system) aspect of the SCR process.

We presented the results of the first pharmacological intervention study aimed to reveal the neurochemical meaning of the parameters in the model of the SCR process. Future work on this issue could refine the method of the psychophysiological probing of the brain monoaminergic signaling systems and render it clinically applicable in: (1) the neurochemical characterization of an individual with a mental disorder and (2) a more informed choice of the psychotropic drugs for his or her treatment.
