**2.8.1 Gross pathology**

The gross pathology of the end-stage AD brain is characterised by widespread atrophy due to the extensive neuronal loss. There is narrowing of gyri and widening of sulci with atrophy of the temporal cortices and a disproportionate atrophy of the entorhinal cortex, amygdala and hippocampus in particular. The remaining cortical regions are generally atrophic, but to a lesser extent than the temporal lobe, although there are also regions seemingly spared from neuronal loss such as the inferior frontal cortex (Halliday *et al.,* 2003) (Fig. 1(a-b)).
