**3. Case example: Toxicokinetics and liver toxicity**

This case example (described below) will highlight an investigation into liver toxicity where the mechanism of the liver toxicity was questioned. This drug candidate induced a strong pharmacological response; therefore, an investigation was launched to investigate whether the liver toxicity induced by this drug was a result of its strong pharmacology or an off target effect (i.e., independent of its targeted receptor pharmacology) from one of the metabolites of the drug.
