**3.5 Sub-chronic toxicity (14 days exposure)**

No treatment deaths occurred and no treatment related clinical signs were noted during the study. The extract did not exert significant changes on mean body and organ weight, fluid and food intake (Table 3). All animals demonstrated a progressive increase in body weight during the exposure. The organ weights were expressed as a percentage of the body weight (% relative organ weight), rather than as absolute weights, so as to take into consideration differences in the organ weight that may solely be attributable to differences in the body weights of the respective rats. The hematology result showed a significant decrease (p<0.05) in red blood count at the dose of 2000mg/kg compared to control (Table 4). The result of the clinical chemistry parameter showed a dose-dependent increase in direct and total bilirubin, there was also an increase in uric acid at the doses of 500 and 1000mg/kg compared to control (Table 5).
