**Meet the editor**

Dr William Acree is currently Professor of Chemistry at the University of North Texas. He has published more than 560 scientific research articles, plus five books, six book chapters and four encyclopedia articles. He serves as a member on the Editorial Advisory Boards of eight journals and has been a manuscript reviewer for over 60 leading international journals. Professor Acree's research

interests involve developing quantitative structure-property relationships and linear free energy relationships to describe partitioning processes of chemical, environmental and pharmaceutical importance. To date he has derived expressions for predicting the solubility of drug molecules in water and in more than 70 organic solvents of varying polarity, for predicting the distribution of organic compounds and drugs between select rat (and human) tissue samples and blood, for predicting the toxicity of organic compounds to several aquatic organisms, and for predicting the solute partitioning between water and numerous organic solvents.

Contents

**Preface IX** 

Chapter 1 **Blood Brain Barrier Permeation 3** 

Amadeo Pesce, Cameron West, Kathy Egan-City and William Clarke

Chapter 3 **Experimental and Computational Methods** 

Chapter 4 **Multi-Well Engineered Heart Tissue** 

Alexandra Eder, Arne Hansen and Thomas Eschenhagen

Chapter 5 **Prediction of Partition Coefficients and** 

and Michael H. Abraham

**Solvent Partition Coefficients 91**  William E. Acree, Jr., Laura M. Grubbs

Chapter 6 **Variability of Plasma Methadone Concentration** 

Nasir Mohamad, Nor Hidayah Abu Bakar, Tan Soo Choon, Sim Hann Liang, NIM Nazar,

Ilya Irinaz Idrus and Rusli Ismail

**in Opiate Dependent Receiving Methadone:** 

Abolghasem Jouyban and Somaieh Soltani

Chapter 2 **Diagnostic Accuracy and Interpretation of Urine Drug** 

**Testing for Pain Patients: An Evidence-Based Approach 25** 

**Pertaining to Surface Tension of Pharmaceuticals 47**  Abolghasem Jouyban and Anahita Fathi-Azarbayjani

**for Drug Screening and Predictive Toxicology 71** 

**Permeability of Drug Molecules in Biological Systems with Abraham Model Solute Descriptors Derived from Measured Solubilities and Water-to-Organic** 

**A Personalised Approach Towards Optimizing Dose 129** 

**Part 1 Drug Design 1** 
