**Preface XIII**

#### **Part 1 Drug Design 1**


X Contents


Chapter 8 **Herbal Medicine in the Treatment of Malaria:** *Vernonia amygdalina***: An Overview of Evidence and Pharmacology 167**  Anoka A. Njan

Contents VII

Chapter 17 **Genotoxic Impurities in Pharmaceuticals 387** Abolghasem Jouyban and Hamed Parsa

Rod G. Gullberg

P.D. Ward

Chapter 18 **Measurement Uncertainty in Forensic Toxicology:**

Chapter 19 **Toxicokinetics and Organ-Specific Toxicity 457**

Kuladip Jana and Parimal C. Sen

Chapter 20 **Environmental Toxicants Induced Male Reproductive** 

**Its Estimation, Reporting and Interpretation 415** 

**Disorders: Identification and Mechanism of Action 473** 

Chapter 9 **Experimental and Computational Methods Pertaining to Drug Solubility 187**  Abolghasem Jouyban and Mohammad A. A. Fakhree

#### **Part 2 Toxicity 219**


Chapter 17 **Genotoxic Impurities in Pharmaceuticals 387**  Abolghasem Jouyban and Hamed Parsa

VI Contents

Chapter 7 **Drug Synergy –** 

**Part 2 Toxicity 219**

Hans-Georg Breitinger

Chapter 8 **Herbal Medicine in the Treatment**

Chapter 9 **Experimental and Computational**

Xianjiang Kang, Shumei Mu, Wenyan Li and Na Zhao

Chapter 12 **Prediction of Toxicity, Sensory Responses** 

and Michael H. Abraham

Chapter 13 *Mikania glomerata* **and** *M. laevigata***:** 

Thais M. Guimarães de Francisco and Francinete Ramos Campos

Chapter 14 **Evaluation of Drug Toxicity for DNA Vaccine** 

Dania Bacardí, Karelia Cosme,

and Santiago Dueñas-Carrera

Chapter 15 **Aluminium Phosphide Poisoning 345**  Babak Mostafazadeh

William E. Acree, Jr., Laura M. Grubbs

**Clinical and Toxicological Advances 297** João Cleverson Gasparetto, Roberto Pontarolo,

**Candidates Against Infectious Diseases: Hepatitis C as Experimental Model 321** 

José Suárez, Yalena Amador-Cañizares

Chapter 16 **Application of a New Genotoxicity Test System**

Tsuneo Hashizume and Hiroaki Oda

**with Human Hepatocyte Cell Lines to Improve the Risk Assessment in the Drug Development 361**

Anoka A. Njan

**of Malaria:** *Vernonia amygdalina***:** 

**Mechanisms and Methods of Analysis 143** 

**Methods Pertaining to Drug Solubility 187**  Abolghasem Jouyban and Mohammad A. A. Fakhree

Chapter 10 **Toxic Effects of Cadmium on Crabs and Shrimps 221** 

Chapter 11 **Paraquat, Between Apoptosis and Autophagy 237**  Rosa A. González-Polo, José M. Bravo-San Pedro, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Mireia Niso-Santano and José M. Fuentes

**and Biological Responses with the Abraham Model 261** 

**An Overview of Evidence and Pharmacology 167**


Preface

issues that we all experience.

Book focuses on experimental in vivo and in vitro methods used to measure the ADMET properties (absorption, distribution, metabolism, excretion and toxicity) of potential drug candidates. Modern drug design also includes in silico computation methods to estimate ADMET properties, and several predictive methods are presented for drug solubility, blood-to-tissue partition coefficients, toxicity, nasal pungency and several other biological and sensory responses. One chapter is devoted to measurement uncertainty, bias and statistical treatment of experimental data. Analytical methods employed to identify and quantify genotoxic pharmaceutical impurities and drug metabolites are also described. Toxicity data from clinical studies are reported. Authors from several countries have contributed chapters detailing regulatory policies, pharmaceutical concerns and clinical practices in their respective countries. The open exchange of scientific results and ideas will hopefully lead to improved pharmaceutical products and a greater awareness of the vast toxicological

**Dr. William Acree** 

United States

University of North Texas,
