**Second Stage of micturition: (figure 1) 2,**

At the age of about 18-24 months, the mother starts to teach her child how to hold up him self until she puts him on a ban. This is gained by building up and having high alpha sympathetic tone, (T 10- L 2) at the IUS keeping the urethra closed and empty all the time until voiding is needed and/or desired and the social circumstances allow (time and proper place are available).

Fig. 1. Diagram that shows the CNS control of the steps taken in the second step of micturition. Sensations of bladder filling travels along the pelvic parasympathetic nerves S.2, 3 &4. Controlled by the CNS, depending on the social circumstances, synergistic neuromuscular actions take place. If time and place do not allow voiding, the person will increase the alpha sympathetic tone at the IUS. He will also inhibit the pelvic parasympathetic preventing detrusor contractions. In addition, he will confirm closure of the external urethral sphincter (EUS).

impulses induce detrusor muscle contraction; as urine enters the urethra it leads to relaxation of the external urethral sphincter (EUS) which is a skeletal muscle innervated by

At the age of about 18-24 months, the mother starts to teach her child how to hold up him self until she puts him on a ban. This is gained by building up and having high alpha sympathetic tone, (T 10- L 2) at the IUS keeping the urethra closed and empty all the time until voiding is needed and/or desired and the social circumstances allow (time and proper

the somatic nerve supply, and thus micturition occurs irrespective of time and place.

Fig. 1. Diagram that shows the CNS control of the steps taken in the second step of micturition. Sensations of bladder filling travels along the pelvic parasympathetic nerves S.2, 3 &4. Controlled by the CNS, depending on the social circumstances, synergistic neuromuscular actions take place. If time and place do not allow voiding, the person will

parasympathetic preventing detrusor contractions. In addition, he will confirm closure of

increase the alpha sympathetic tone at the IUS. He will also inhibit the pelvic

the external urethral sphincter (EUS).

**Second Stage of micturition: (figure 1) 2,** 

place are available).

Sensations of bladder distension travel along the pelvic parasympathetic (S. 2, 3 & 4) to the central nervous system (CNS). Controlled by the high CNS, sensations of desire to void and bladder fullness, allows the person to choose either to retain the urine to a later time or to void according to the social circumstances available. If he chooses to retain the urine then three neuro-muscular actions take place: 1- He increases the alpha sympathetic tone to the IUS confirming its closure. 2- He inhibits the parasympathetic impulses to the detrusor muscle inhibiting its contractions. 3- He increases the tone of the EUS which is a skeletal muscle innervated by voluntary nervous system. When, appropriate time and place are available, then, controlled by the CNS, synergistic actions between the somatic and the autonomic nervous systems four neuro-muscular actions take place. (1) He will lower the high alpha sympathetic tone at the IUS relaxing the sphincter and opening the urethra, (2) he relaxes the EUS which is a striated muscle innervated by somatic nerve supply, (3) he activates the pelvic parasympathetic nerves to induce contraction of the detrusor muscle and empty the urinary bladder.

(4) The external urethral sphincter (Compressor Urethrae) acts to propagate and propel the stream of urine and at the end to squeeze the urethra to expel the last drops of urine in the urethra to keep the urethra closed and empty as it should be.

When social circumstances allow, he will inhibit the high alpha sympathetic tone at the IUS, thus opening the urethra. He will activate the pelvic parasympathetic inducing detrusor contractions. He will relax the EUS thus allowing voiding. The EUS tone increase to allow propulsion and ejection of the stream of urine and at the end of micturition to squeeze the urethra from the last few amount of urine. The grey drawing is from the scientific net pages on micturition, www.obgyn.net

In addition, we described the structure of the vagina in a novel way 1 & 7. The vagina is composed of collagen-muscular-elastic layer. The collagen layer is the tough layer that give the vaginal walls their strength and to keep the vagina in its upward position. Childbirth, especially prolonged, difficult, repeated & frequent and instrumental vaginal deliveries cause overstretching of the vagina with subsequent rupture of it collagen sheet. The rupture of the vagina affects mainly its transverse axis leading to flabby redundant vaginal walls with subsequent vaginal prolapse. The same trauma will affects the intimately overlying IUS leading to rupture of its collagen layer. The torn weak IUS will not stand sudden increase of abdominal pressure as coughing, jumping, sneezing, laughing and even coitus, and urine will leak involuntary, stress urinary incontinence (SUI). As soon as the woman feels wetting herself due to escape of urine, being embarrassed, reactive sympathetic activity reflex, will increase the sympathetic tone at the IUS to confirm its closure and preventing further leak of urine. This may explain the strong indications that there is a causal relationship between OAB and POP (8-18). Thus by understanding this new concept, we can explain most of the voiding troubles.

Functional disturbances, and/or structural damage of the IUS will lead to urinary incontinence, and voiding troubles 1-7.

1. Failure to acquire the second stage of micturition leads to Nocturnal Enuresis. These failures can be complete failure, (here there is a stop at the first stage of micturition), as the urinary bladder fills it empties irrespective to neither time nor place, leading to day

The Concept and Pathophysiology of Urinary Incontinence 149

Fig. 3. Sympathetic failure due to getting drunk, leads to transient urinary incontinence.

Fig. 4. A diagram to explain the site, extent and structure of the IUS and the EUS. On the left, (A) the IUS is a muscular ring at the bladder neck as described classically, on the right (B),

the IUS as described in the new way.

and night enuresis. About ten per cent of nocturnal enuresis patients suffer from diurnal enuresis as well.

The failure can be partial, during waking time as the bladder is full and there is a feeling of a desire to void, the patient will be embarrassed of wetting himself. Therefore, he increases the alpha sympathetic tone closing the IUS further preventing involuntary urination until he reaches the toilet, but on sleeping this weak partial alpha sympathetic tone will be lost and nocturnal enuresis will occur. This occurs in 90 per cent of nocturnal enuresis patients. Therefore, the treatment of nocturnal enuresis is not by giving anti-cholinergic drugs, but by giving alpha sympathomemmitc drugs 5.


Fig. 2. Severe fear cause transient urinary incontinence.

diurnal enuresis as well.

surgery), leads to retention of urine.

urine or retention with overflow.

Fig. 2. Severe fear cause transient urinary incontinence.

and night enuresis. About ten per cent of nocturnal enuresis patients suffer from

The failure can be partial, during waking time as the bladder is full and there is a feeling of a desire to void, the patient will be embarrassed of wetting himself. Therefore, he increases the alpha sympathetic tone closing the IUS further preventing involuntary urination until he reaches the toilet, but on sleeping this weak partial alpha sympathetic tone will be lost and nocturnal enuresis will occur. This occurs in 90 per cent of nocturnal enuresis patients. Therefore, the treatment of nocturnal enuresis is not by

giving anti-cholinergic drugs, but by giving alpha sympathomemmitc drugs 5. 2. Sympathetic over activity e.g., painful stimuli (e.g. episiotomy, abdominal or pelvic

3. Spinal cord injury below the second lumbar neural level or spinal anesthesia, or diseases like SLE and disseminated sclerosis (DS) leads to loss of the pelvic parasympathetic sparing the thoraco-lumbar sympathetic supply will cause retention of

4. Sympathetic failure, like severe fear (figure 2) leads to transient urinary incontinence.

Also alcohol, getting drunk (figure 3) may lead to transient UI.

Fig. 3. Sympathetic failure due to getting drunk, leads to transient urinary incontinence.

Fig. 4. A diagram to explain the site, extent and structure of the IUS and the EUS. On the left, (A) the IUS is a muscular ring at the bladder neck as described classically, on the right (B), the IUS as described in the new way.

The Concept and Pathophysiology of Urinary Incontinence 151

Fig. 8. Coronal section of the urinary bladder and the IUS as seen by 3DUS imaging showing uniform thickness of the intact IUS extending from the bladder neck downwards. You can kindly notice the muscle lying on the collagen cylinder and has a connection above with the

detrusor muscle.

Fig. 7. Images by 3DUS and 4DUS of a normal healthy intact IUS.

The IUS is described by the new concept and as is seen by imaging (by three dimension ultrasound 3DUS and magnetic resonance MRI) is a cylinder that extends from the bladder neck to the urogenital diaphragm and is not a muscular ring at the bladder neck. (Figures 5, 6, 7, 8 & 9)

Fig. 5. On the left a diagram of the IUS as a cylinder of collagen-muscular tissue cylinder lined by urothelium is shown. On the right 3DUS image of a normal continent woman with the IUS seen as a cylinder that extends from the urinary bladder neck downwards with 2 echoes overlying each other, and a closed urethra.

Fig. 6. Cross section of the IUS as seen by 3DUS image, it shows a closed urethral lumen, surrounded by a cylinder of collagen with superimposed muscle on top and intermingling with the collagen fibers in the mid thickness of the cylinder.

The IUS is described by the new concept and as is seen by imaging (by three dimension ultrasound 3DUS and magnetic resonance MRI) is a cylinder that extends from the bladder neck to the urogenital diaphragm and is not a muscular ring at the bladder neck. (Figures 5,

Fig. 5. On the left a diagram of the IUS as a cylinder of collagen-muscular tissue cylinder lined by urothelium is shown. On the right 3DUS image of a normal continent woman with the IUS seen as a cylinder that extends from the urinary bladder neck downwards with 2

Fig. 6. Cross section of the IUS as seen by 3DUS image, it shows a closed urethral lumen, surrounded by a cylinder of collagen with superimposed muscle on top and intermingling

with the collagen fibers in the mid thickness of the cylinder.

echoes overlying each other, and a closed urethra.

6, 7, 8 & 9)

Fig. 7. Images by 3DUS and 4DUS of a normal healthy intact IUS.

Fig. 8. Coronal section of the urinary bladder and the IUS as seen by 3DUS imaging showing uniform thickness of the intact IUS extending from the bladder neck downwards. You can kindly notice the muscle lying on the collagen cylinder and has a connection above with the detrusor muscle.

The Concept and Pathophysiology of Urinary Incontinence 153

3. Further weakness and rupture of the vaginal collagen will induce vaginal wall

Fig. 10. MRI pictures of Normal tough vagina, which is standing up because of its tough

Fig. 11. MRI pictures, cross sections, (A) the vagina is seen H-shape in nulliparous woman with intact IUS. (B) Vaginal delivery transform the vagina is into transverse slit, the IUS is intact. (C) The vagina is more lax, the IUS is intact. (D) The vagina is torn and prolapsed;

redundancy and descent.

collagen sheet.

also, the IUS is torn.

Fig. 9. MRI picture of a patient with Mullerian duct agensis (absent uterus and vagina) that shows the IUS as a thick tissue cylinder that extends from the bladder neck downwards to the perineal membrane.

The level and the extent of the lacerations along the cylinder of the IUS will determine the type and severity of SUI, and the morphological shape seen on imaging the IUS with 3DUS and MRI. When the damage affects mainly in the upper part of the IUS, DO (over active bladder, OAB) will ensue. If the damage is mainly in the lower part, then genuine, urodynamic, SUI ensues. If the damage affects the entire length of the IUS, mixed type of UI is the result.

A tough and a strong anterior vaginal wall (figures 10 & 11) is an essential support for keeping the vagina in its upward position, and is a major support for the intimately overlying IUS and the lower part of the posterior wall of the urinary bladder on filling. A weak overstretched and flabby anterior vaginal wall will fall down (prolapse), with its overlying damaged IUS and lower part of the posterior wall of the urinary bladder on filling. The strength and the toughness of the vaginal wall depend on its rich compact collagen sheet. The compact tough collagen bundles are essential elements of keeping the vagina in its normal upward position without descending or falling down. As an example, a hardcover book will stand upright on a shelf, while a paper-cover book will fall down.

Childbirth trauma causes over stretching of the vagina with attenuation, split and actual lacerations of the collagen bundles in the vagina leading to weakness and laxity of the vaginal wall. The weakness and rupture of the vaginal collagen sheet will manifest itself mostly in the transverse axis of the vagina.

Clinically and on imaging (figure 11) will demonstrate this:


Fig. 9. MRI picture of a patient with Mullerian duct agensis (absent uterus and vagina) that shows the IUS as a thick tissue cylinder that extends from the bladder neck downwards to

The level and the extent of the lacerations along the cylinder of the IUS will determine the type and severity of SUI, and the morphological shape seen on imaging the IUS with 3DUS and MRI. When the damage affects mainly in the upper part of the IUS, DO (over active bladder, OAB) will ensue. If the damage is mainly in the lower part, then genuine, urodynamic, SUI

A tough and a strong anterior vaginal wall (figures 10 & 11) is an essential support for keeping the vagina in its upward position, and is a major support for the intimately overlying IUS and the lower part of the posterior wall of the urinary bladder on filling. A weak overstretched and flabby anterior vaginal wall will fall down (prolapse), with its overlying damaged IUS and lower part of the posterior wall of the urinary bladder on filling. The strength and the toughness of the vaginal wall depend on its rich compact collagen sheet. The compact tough collagen bundles are essential elements of keeping the vagina in its normal upward position without descending or falling down. As an example, a hardcover book will stand upright on a shelf, while a paper-cover book will fall down.

Childbirth trauma causes over stretching of the vagina with attenuation, split and actual lacerations of the collagen bundles in the vagina leading to weakness and laxity of the vaginal wall. The weakness and rupture of the vaginal collagen sheet will manifest itself

1. At first, there will be loss of the nulliparous H-shape vagina, which changes into a

2. Then, further weakness, will lead to loss of vaginal rugae; the vaginal wall will be

ensues. If the damage affects the entire length of the IUS, mixed type of UI is the result.

the perineal membrane.

mostly in the transverse axis of the vagina.

transverse slit in parous women.

Clinically and on imaging (figure 11) will demonstrate this:

smooth without folds as can be seen clinically.

3. Further weakness and rupture of the vaginal collagen will induce vaginal wall redundancy and descent.

Fig. 10. MRI pictures of Normal tough vagina, which is standing up because of its tough collagen sheet.

Fig. 11. MRI pictures, cross sections, (A) the vagina is seen H-shape in nulliparous woman with intact IUS. (B) Vaginal delivery transform the vagina is into transverse slit, the IUS is intact. (C) The vagina is more lax, the IUS is intact. (D) The vagina is torn and prolapsed; also, the IUS is torn.

The Concept and Pathophysiology of Urinary Incontinence 155

weakness is mostly due to traumatic injury of the IUS causing rupture, and/or split of the collagen tissue cylinder, the essential constituent of the IUS. Nevertheless, weakness of the pelvic collagen (collagen of the IUS and the collagen of the vagina) can be caused by, or exaggerated, by other causes e.g. (1) hormone deficiency particularly after menopause. (2) Chronic or repeated genito-urinary infections may lead to degeneration of the pelvic

Fig. 13. Coronal sections of MRI pictures of a normal continent woman on the left showing healthy uniform cylinder compared to torn IUS on the right, the whole length is torn, showing funneling in the upper part and flak-shape appearance in the lower part ( the

woman is complaining of Mixed type of UI).

collagen and its weakness. (3) Congenital collagen weakness.

In patients suffering SUI, the IUS is torn and disrupted with echo-lucent areas in 3DUS images (Figures 12-19). Depending on the level and extent of the damage along the cylinder there are different morphological and functional changes. When the damage affects mainly the upper part there will be funneling of the urinary bladder neck with loss of the urethrovesical angle and apparent descent of the bladder neck and shortening of the urethra. Urine will enter the upper part of the urethra on sudden increase of intra-vesical pressure giving sensation of sudden desire to void, DO. When the damage affects mainly the lower part there will be a flask-shape appearance, and genuine SUI ensues. When the damage affects the entire length there will be collapse of the urethra, with apparent shortening and mixed type of urinary incontinence.

Fig. 12. Sagittal section of MRI picture showing the IUS seen as a cylinder that extends from the bladder neck to the perineal membrane. Rupture of the IUS is mainly in the upper part causing funneling of the bladder neck (leading to DO).

The torn weak IUS with a lower UCP will, on sudden increases of abdominal pressure, intra- vesical pressure, give way, with resultant leakage of urine. Leakage of urine will induce a rapid reactive sympathetic activity that will increase the sympathetic tone at the IUS preventing further loss of urine (10, 11, 12, 13, 14 &15).

In some patients suffering from SUI, the urodynamic studies show high UCP at rest. Cases where there is just splitting of the compact collagen tissue cylinder, without any observable defective rupture in this compact layer, leaving the IUS with high wall tension. However, on stress the split weak wall yields leading to leakage of urine. 3DUS and MR imaging can better assess the defect. Weakness of the IUS leads to SUI, DO and mixed type of UI. The

In patients suffering SUI, the IUS is torn and disrupted with echo-lucent areas in 3DUS images (Figures 12-19). Depending on the level and extent of the damage along the cylinder there are different morphological and functional changes. When the damage affects mainly the upper part there will be funneling of the urinary bladder neck with loss of the urethrovesical angle and apparent descent of the bladder neck and shortening of the urethra. Urine will enter the upper part of the urethra on sudden increase of intra-vesical pressure giving sensation of sudden desire to void, DO. When the damage affects mainly the lower part there will be a flask-shape appearance, and genuine SUI ensues. When the damage affects the entire length there will be collapse of the urethra, with apparent shortening and mixed

Fig. 12. Sagittal section of MRI picture showing the IUS seen as a cylinder that extends from the bladder neck to the perineal membrane. Rupture of the IUS is mainly in the upper part

The torn weak IUS with a lower UCP will, on sudden increases of abdominal pressure, intra- vesical pressure, give way, with resultant leakage of urine. Leakage of urine will induce a rapid reactive sympathetic activity that will increase the sympathetic tone at the

In some patients suffering from SUI, the urodynamic studies show high UCP at rest. Cases where there is just splitting of the compact collagen tissue cylinder, without any observable defective rupture in this compact layer, leaving the IUS with high wall tension. However, on stress the split weak wall yields leading to leakage of urine. 3DUS and MR imaging can better assess the defect. Weakness of the IUS leads to SUI, DO and mixed type of UI. The

causing funneling of the bladder neck (leading to DO).

IUS preventing further loss of urine (10, 11, 12, 13, 14 &15).

type of urinary incontinence.

weakness is mostly due to traumatic injury of the IUS causing rupture, and/or split of the collagen tissue cylinder, the essential constituent of the IUS. Nevertheless, weakness of the pelvic collagen (collagen of the IUS and the collagen of the vagina) can be caused by, or exaggerated, by other causes e.g. (1) hormone deficiency particularly after menopause. (2) Chronic or repeated genito-urinary infections may lead to degeneration of the pelvic collagen and its weakness. (3) Congenital collagen weakness.

Fig. 13. Coronal sections of MRI pictures of a normal continent woman on the left showing healthy uniform cylinder compared to torn IUS on the right, the whole length is torn, showing funneling in the upper part and flak-shape appearance in the lower part ( the woman is complaining of Mixed type of UI).

The Concept and Pathophysiology of Urinary Incontinence 157

Fig. 16. MRI picture sagittal view, there is rupture of the IUS. The rupture is in the

patient is post menopause) is causing atrophy of the collagen sheet.

collagenous sheet; the muscle layer is intact and has a connection above with the detrusor muscle. In addition to the rupture of the collagen sheet of the IUS, hormone deficiency, (the

Fig. 17. Trans-rectal 3DUS image of the IUS and the anterior vaginal wall that shows torn posterior wall of the IUS together with the anterior vaginal wall. The symphsis pubis is

protecting the anterior wall of the IUS.

Fig. 14. Images by 3DUS, picture (A) a normal IUS, compared to torn IUS (B, C & D). The whole length is torn in (B); the rupture is mainly in the lower part in (C) leading to genuine SUI and flask-shape appearance. There is a loss of Posterior U-V angle in (D) with widely open urethra.

Fig. 15. Cross sections of 3DUS images of torn IUS compared to normal IUS.

Fig. 14. Images by 3DUS, picture (A) a normal IUS, compared to torn IUS (B, C & D). The whole length is torn in (B); the rupture is mainly in the lower part in (C) leading to genuine SUI and flask-shape appearance. There is a loss of Posterior U-V angle in (D) with widely

Fig. 15. Cross sections of 3DUS images of torn IUS compared to normal IUS.

open urethra.

Fig. 16. MRI picture sagittal view, there is rupture of the IUS. The rupture is in the collagenous sheet; the muscle layer is intact and has a connection above with the detrusor muscle. In addition to the rupture of the collagen sheet of the IUS, hormone deficiency, (the patient is post menopause) is causing atrophy of the collagen sheet.

Fig. 17. Trans-rectal 3DUS image of the IUS and the anterior vaginal wall that shows torn posterior wall of the IUS together with the anterior vaginal wall. The symphsis pubis is protecting the anterior wall of the IUS.

The Concept and Pathophysiology of Urinary Incontinence 159

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**3. References** 

Fig. 18. MRI, sagittal view of a patient with DO that shows torn upper part of the IUS with funneling. The IUS is seen clearly as a compact tissue cylinder that extends from the bladder neck downwards.

Fig. 19. 3DUS images of normal intact IUS on the upper left corner compared to a nice funnel on the upper right, the lower 2 images show torn the whole length with funneling of the upper part and flask-shape in the lower part.

#### **3. References**

158 Urinary Incontinence

Fig. 18. MRI, sagittal view of a patient with DO that shows torn upper part of the IUS with funneling. The IUS is seen clearly as a compact tissue cylinder that extends from the bladder

Fig. 19. 3DUS images of normal intact IUS on the upper left corner compared to a nice funnel on the upper right, the lower 2 images show torn the whole length with funneling of

the upper part and flask-shape in the lower part.

neck downwards.


**Part 2** 

**The Overactive Bladder** 

