**Meet the editor**

Dr. Chan is currently a Professor of Medicine at the Université de Montréal and the Chief of the Laboratory of Molecular Nephrology and Endocrinology at the Research Centre of Centre hospitalier de l'Université de Montréal (CRCHUM). Dr. Chan's research program seeks to understand the role(s) of intrarenal renin angiotensin system (RAS) and oxidative stress

in the pathogenesis of diabetic nephropathy, with special emphasis on renal angiotensinogen gene expression and reactive oxygen species (ROS) generation on tubular apoptosis in diabetes. Dr. Chan has published over 100 papers in scientific journals and presented more than 250 abstracts in various scientific societies. Dr. Chan's research program is supported by several peer-reviewed granting agencies including the Canadian Institutes of Health Research, Kidney Foundation of Canada, Canadian Diabetes Association and Canadian Foundation of Innovation.

Contents

**Preface IX** 

Chapter 3 **Diabetic Nephropathy:** 

Rozina Rani

Uh-Hyun Kim

**Section 1 Systemic and Local Intrarenal** 

**Renin-Angiotensin-Aldosterone System in the Development of Diabetic Nephropathy 1** 

**Development of Diabetic Nephropathy 3** 

**in Diabetes and Hypertension: Implications on the** 

Fernanda Aparecida Ronchi, Danielle Sanches Aragão, Rodolfo Mattar Rosa, Nadia Sousa Cunha Bertoncello

**Tubular Atrophy in Diabetic Nephropathy 31** 

**Therapy with Aldosterone Receptor Blocker 41** 

**Section 2 Novel Therapeutic Molecules in Diabetic Nephropathy 83** 

**a Therapeutic Tool for Diabetic Nephropathy 85** 

Chapter 6 **Significance of Advanced Glycation End-Products (AGE) and** 

**the Receptor for AGE (RAGE) in Diabetic Nephropathy 97**  Tarek Kamal, Yasuhiko Yamamoto and Hiroshi Yamamoto

Dulce Elena Casarini, Danielle Yuri Arita, Tatiana Sousa Cunha,

Chapter 1 **Up-Regulation of Renin-Angiotensin System** 

and Fernanda Klein Marcondes

Brice E. T. Nouthe, Maya Saleh, Shao-Ling Zhang and John S. D. Chan

Chapter 4 **Drug and Diabetic Nephropathy 57** 

Chapter 5 **Kidney ADP-Ribosyl Cyclase Inhibitors as** 

Chapter 2 **Renal Angiotensinogen Gene Expression and** 

**Role of Aldosterone and Benefits of** 

Jayson Yap and Mohammad G. Saklayen

### Contents

#### **Preface XI**


Tarek Kamal, Yasuhiko Yamamoto and Hiroshi Yamamoto


### Preface

The idea for publishing a book on diabetic nephropathy has been developed during the last several years as my interest in studying diabetic complications has increased. The need for a book that described the various novel and old molecules involved in the development of diabetic nephropathy and the trend of future research became apparent. The book describes the important role of intrarenal reninangiotensin-aldosterone system and immune system in the development of diabetic nephropathy as well as provided data on the biochemical and pathological changes in diabetic nephropathy. Relevant information on the treatments of diabetic nephropathy is also provided.

The authors are internationally known for their work in diabetic nephropathy. Each chapter has been peer-reviewed and edited and provide up-to-date information on the topic.

I hope that the book will be useful for researchers working in the field of diabetic nephropathy.

> **John S. D. Chan** Professor of Medicine at the Université de Montréal, Chief of the Laboratory of Molecular Nephrology and Endocrinology, Research Centre - Centre hospitalier de l'Université de Montréal (CRCHUM) Montréal, Canada

**Section 1** 

**Systemic and Local Intrarenal** 

**Renin-Angiotensin-Aldosterone System in** 

**the Development of Diabetic Nephropathy** 
