**3. Conclusion**

The presented results indicate that extracts from lignicolous macrofungi could be used in the prevention and treatment of Gram-positive bacterial infections resistant to antibiotics in animals (humans), although further toxicity assays (*in vivo*) must be performed before its application. The fact that fungi can have bactericidal properties with low cytotoxicity to the animal host underscores their usefulness as natural sources of human or veterinary medicines.

Antibacterial Agents from Lignicolous Macrofungi 381

Berger-Bachi, B. (2002). Resistence mechanism of Gram-positive bacteria. Mini review.

Berghe, D.A.; Vlietinck, A.J. (1991). Screening Methods for Antimicrobial and Antiviral Agents from Higher Plants. *Methods in Plant Biochemistry*, Vol.6, pp. 47-69. Biradar, Y.S., S. Jagatap, K.R. Khandelwal and S.S. Singhania (2008). Exploring of

Calabrese, E.J.; Baldwin, L.A. (2001). The scientific foundation of hormesis. *Critical Reviews in* 

Ćetković, G.S.; Djilas, S.M.; Čanadanović, J.M.; Tumbas, V.T. (2004). Antioxidant properties of marigold extracts. *Food Research International*, Vol.37, pp. 643-650, Cetto, B. (1979). Der grosse Pilzführer. BLV Verlagsgesellschaft, NSIB , Wien, Austria. Cheesman, K.H.; Bearis, A.; Esterbauer, H. (1988). Hydroxyl-radical-induced iron catalyzed degradation of 2-deoxyribose. *Biochemical Journal*, Vol.252, No.3, pp. 649-653. Chen, J., Seviour, R. (2007): Medicinal importance of fungal - (1→ 3), (1→ 4) - glucans.

Chu, K. T., Xia, L., Ng, T. B. (2005) : Pleurostrin, an antifungal peptide from the oyster

Clinical and Laboratory Standards Institute. Methods for dilution susceptibility test for

Courtecuisse, R. & Duhem, B. (1995). Mushrooms & toadstools of Britain and Europe.

Cowan, M.M. (1999). Plant products as antimicrobial agents. Clinical Microbiologicy

Cui, Y.; Kim, D.S.; Park, K.C. (2005). Antioxidant effect of Innonotus obliquus. *Journal of* 

de Silva, E. D., van der Sar, S. A., Santha, R. G. L., Wijesundera, R. L. C., Cole, A. L. J., Blunt,

Dubost, N.J.; Ou, B.; Beelman, R.B. (2007). Quantification of polyphenols and ergothioneine

Egger, H. & Reinshagen, H. (1976). New pleuromutili derivatives with enhanced

Elmastas, M.; Isildak, O.; Turkekul, I.; Temur, N. (2007). Determination of antioxidant

Engler, M.; Anke, T.; Sterner, O. (1998). Production of Antibiotics by Collybia nivalis,

J. W., Munro, M. H. G. (2006): Lanostane Triterpenoids from the Sri Lankan Basidiomycete Ganoderma applanatum. *Journal of Natural Products*, 69: 1245-1248. Deyrup, S.T.; Gloer, J.B.; O'Donnell, K.; Wicklow, D.T. (2007). Kolokosides A-D:

Triterpenoid Glycosides from a Hawaiian Isolate of Xylaria sp. *Journal of Natural* 

in cultivated mushrooms and correlation to total antioxidant capacity. *Food* 

antimicrobial activity. II. Structure-activity correlations. *Journal of Antibiotics*,

activity and antioxidant compounds in wild edible mushrooms. *Journal of Food* 

Omphalotus olearius, a Favolashia and a Pterula species on natural substrates.

bacteria that grow aerobically. 6th edition. Approved standard. (2003). Clinical and

antimicrobial activity of triphala mashi-an ayurvedic formulation. *Evidence-based* 

*International Journal of Medicinal Microbiology*, Vol.292, pp. 27-35.

*Complementary and Alternative Medicine*, 5: 107-113.

*Toxicology*. Vol.31, pp. 349-691

*Mycological research*, 3: 635-652.

mushroom. *Peptides*, 26 (11): 2098-2103.

Laboratory Standards Institute, NSIB , Wayne, USA

Harper Collins Publishers, NSBI , London, England.

Reviews. Vol.12, No.4, (October), pp. 564-582,

*Ethnopharmacology*, Vol.96, No.1-2, pp. 79-85.

*Composition and Analysis*, Vol.20, pp. 337-345.

*Zeitschrift für Naturforschung C*, Vol.53, No.5-6, pp. 318-324.

*Products*, Vol.70, No.3, pp. 378-382.

*Chemistry*, Vol.105, pp. 727-735.

Vol.29, pp. 923-927.

Also, the results obtained should stimulate further studies of other, so far unexplored, species such as *M. giganteus* and *P. tigrinus*, since current knowledge of the antibacterial activities or chemical composition of their active agents is not capable of fulfilling the expectations.

#### **4. Acknowledgment**

This work is fully supported by the project No 172058 of Ministry of Education and Science of Republic of Serbia

#### **5. References**


Also, the results obtained should stimulate further studies of other, so far unexplored, species such as *M. giganteus* and *P. tigrinus*, since current knowledge of the antibacterial activities or chemical composition of their active agents is not capable of fulfilling the expectations.

This work is fully supported by the project No 172058 of Ministry of Education and Science

Abraham, W.R. (2001). Bioactive sesquiterpenes produced by fungi: are they useful for

Ajith, T.A. & Janardhanan K.K. (2007). Indian Medicinal Mushrooms as a source of

Akisha T, Tagata M, Ukiya M, Tokuda H, Suzuki T, Kimura Y. (2005): Oxygenated

Aldred, D.**,** Magan, N.**,** Lane B. S. (1999)**.** Influence of water activity and nutrients on growth

Anke, T., Besl, H., Mocek, U., Steglich, W. (1979): Antibiotics from basidiomycetes. IX.

Anke, T., Werle, A., Kapre, R., Sterner, O. (2004): Laschiatrion, a New Antifungal Agent

Asatiani, M., Elisashvili, V., Wasser, S.P., Reznick, A.Z., Nevo, E. (2007). Antioxidant activity

Asatiani, M.D.; Kachlishvili, E.T.; Khardziani, T.S.; Metreveli, E.M.; Mikiashvili, N.A.;

Bendini, A.; Bonoli, M.; Cerretani, L.; Biguzzi, B.; Lercker, G.; Toshi, T.G. (2003). Liquid-

Fr.) Hoehnel (Agaricales). *The Journal of Antibiotics*, 32 (11): 1112-1117. Anke, T., Besl, H., Mocek, U., Steglich, W. (1983): Antibiotics from basidiomycetes. XVIII.

species (Agaricales). *The Journal of Antibiotics*, 36 (6): 661-666.

*International Journal of Medicinal Mushrooms,* Vol*.*9, pp. 151-158.

The Journal of Antibiotics, 57 (8): 496-501.

*Toxycology*, Vol.46, No.8, (August), pp. 2742-2747.

*Chromatography A*, Vol.985, No.1-2, pp. 425-433.

antioxidants and antitumor agents. *Journal of Clinical Biochemistry and Nutrition,* 40,

Lanostane-Type Triterpenoids from Fungus *Ganoderma lucidum*. *Journal of Natural* 

and production of squalestatin S1 by a *Phoma* sp. *Journal of Applied Microbiology*,

Oudemansin, an antifungal antibiotic from Oudemansiella mucida (Schrader ex

Strobilurin C and oudemansin B, two new antifungal metabolites from Xerula

from a Favolaschia Species (Basidiomycetes) Active against Human Pathogens.

of submerged cultured mycelium extracts of higher Basidiomycetes Mushrooms.

Songulashvili, G.G. et al. (2008). Basidiomycetes as a source of antioxidants, lectins, polysaccharides and enzymes. *Journal of Biotechnology*, Vol.136S, pp. S717-S742. Barros, L.; Calhelha, R.C.; Vaz, J.A.; Ferreira, I.C.F.R.; Baptista, P.; Esteviinho, L.M. (2007).

Antimicrobial activity and bioactive compounds of Portugese wild edible mushrooms methanolic extracts. *European Food Research and Technology*, Vol.225, pp. 151-156, Barros, L.; Cruz, T.; Baptista, P.; Estevinho, L.M.; Ferreira, I.C.F.R. (2008). Wild and

commercial mushrooms as source of nutrients and nutraceuticals. *Food and Chemical* 

liquid and solid-phase extractions of phenols from virgin olive oil and their separation by chromatographic and electrophoretic methods. *Journal of* 

humans as well. *Current Medical Chemistry,* 8: 583-606.

**4. Acknowledgment** 

of Republic of Serbia

pp. 157-162.

*Products.* 68:559-563.

Vol.87, No. 6, pp. 842-848.

**5. References** 


Antibacterial Agents from Lignicolous Macrofungi 383

Jayakumar, T.; Thomas, P.A.; Geraldine, P. (2009). In vitro antioxidant activities od an

Jian, H.; Xiao-Zhang, F.; Yang, L.; Bin, Z. (2003). FomLactones A-C, Novel Triterpene Lactones from Fomes cajanderi. *Journal of Natural Products*, Vol.66, pp. 1249-1251. Kalyoncu, F.; Oskay, M.; Sağlam, H.; Erdoğan, T.F.; Tamer, A.U. (2010). Antimicrobial and

Kamo, T.; Asanoma, M.; Shibata, H. & Hirota, M. (2003). Anti-inflamantory lanostane–type acids from *Piptoporus betulinus*. *Journal of Natural Products,* 66, pp. 1104-1106. Karaman A.M. (2009c). Autochtonous fungal species of Basidiomycotina – potential resources of naturally active substances. PhDThesis. University of Novi Sad. Karaman M, Novakovic M, Matavulj M. (2012b). Fundamental fungal strategies in restoration of

Karaman M., Vesic, M, Stahl, M, Novakovic M., Janjic Lj., Matavuly M. (2012a): "Bioactive

Karaman, A.M.; Matavulj, N.M. (2005): Macroelements and heavy metals in some

Karaman, M. (2002). "Content of Macroelements and Heavy Metals in sporocarps of

Natural Sciences and Mathematics. Department of Biology and Ecology. Karaman, M., Jovin, E., Malbaša, R., Matavuly, M., Popović, M. (2010). Medicinal and Edible

Karaman, M., Mimica-Dukić, N., Knežević, P., Svirčev, Z., Matavulj, M. (2009a): Antibacterial

Karaman, M.; Kaišarević, S.; Somborski, J.; Kebert, M.; Matavuly, M. (2009b): Biological

Kavanagh F., Hervey, A. & Robbins (1950): Antibiotic substances from Basidiomycetes. VI.Agrocybe dura. *Proceedings of Natural Academy Sciences* U S A. 36: 102-106. Kavanagh, F.; Hervey, A.; Robbins, W.J. (1951). Antibiotic substances from basidiomycetes.

Kim, H.W. & Kim, B.K. (1999). Biomedicinal triterpenoids of Ganoderma lucidum

Kim, M.Y.; Seguin, P.; Ahn, J.K.; Kim, J.J.; Chun, S.C.; Kim, E.H.; Seo, S.H.; Kang, E.Y.; Kim,

*International Journal of Medicinal Mushrooms*, Vol.11, No.3, pp. 269-279.

*Phytotherapy Research*; Vol.24, No.10, pp. 1473-1481.

*of Biological Sciences,* Vol.61, No.4, pp. 353-361.

*Natural Academic Science*; 37, pp. 570-574.

*Mushrooms*, 1, pp. 121-138.

and role in disease. New York: Nova Science Publishers Inc; In press.

*Science and Emerging Technologies*, Vol.10, No.2, pp. 228-234.

*Food*. Vol.13, No.2, pp. 415-419.

Validation", pp. 361-377.

Novi Sad, 108, 255-267.

39-45.

metabolites from mycelial culture of Flammulina velutipes. *Mycoscience,* Vol.46, pp.

ethanolic extract of the oyster mushroom, Pleurotus ostreatus. *Innovaative Food* 

antioxidant activities of mycelia of 10 wild mushroom species. *Journal of Medicinal* 

natural environment. In: Vazquez, Silva editors. Fungi: Types, environmental impact

Properties of Wild-Growing Mushroom Species *Ganorderma applanatum* (Pers.) Pat. from Fruska Gora Forest (Serbia)". RPMP Vol. 32: "Ethnomedicine and Therapeutic

lignicolous and tericolous fungi. *Proceedings of Natural Scieneces*, Matica Srpska

dominately present Basidiomycotina fungi from the Fruska gora Mountain and their antioxidative activity". Master Degree. University of Novi Sad. Faculty of

Lignicolous Fungi as Natural Sources of Antioxidative and Antibacterial agents.

properties of selected lignicolous mushrooms and fungi from northern Serbia.

activities of the lignicolous fungus Meripilus giganteus (Pers.:Pers.) Karst. *Archives* 

VIII. Pleurotus mutilus (Fr) Sacc. and Pleurotus passeckierianus Pilat. *Proceedings of* 

(Curt.:Fr.)P. Karst. (aphyllophoromicetidae). *International Journal of Medicinal* 

S.L. ; Park, Y.J. ; Ro, H.M. & Chung, I.M. (2008). Phenolic compound concentration


Fan, J. M., Zhang, J. S., Tang, Q. J., Liu, Y. F., Zhang, A. Q., Pan, Y. J. (2006): Structural

Ferreira, I.C.F.R.; Barros, L.; Abreu, R.M.V. (2009). Antioxidants in Wild Mushrooms.

Florey, H.W.; Chain, W.; Heatley, A.; Jennings, M.A.; Sanders, A.G.; Abraham, E.P.; Florey, M.E. (1949). Antibiotics. Oxford University Press, London, England. Fukumoto, L. & Mazza, G. (2000). Assessing antioxidant and prooxidant activities of

Gentry, D.R.; Wilding, I.; Johnson, J. M.; Chen, D.; Remlinger, K.; Richards, C. et al. (2010). A

Giovaninni, I. S. (2006). Cultivated Basidiomycetes as a source of new products: - in vitro

Griffin, S.P. & Bhagooli, R. (2004). Measuring antioxidant potential in corals using the FRAP assay. *Journal of Experimental Marine Biology and Ecology*, Vol.302, pp. 201-211. Gunde-Cimerman, N. & Cimerman, A. (1995). Pleurotus fruiting bodies contain the inhibitor of HMG CoA reductase- lovastatin. *Experimental Mycology*. Vol.19, No.1, pp. 1-6. GuoY., Wang H., Ng T.B. (2005): Isolation of trichogin, an antifungal protein from fresh fruiting bodies of the edible mushroom Tricholoma giganteum. *Peptides,* 26: 575–580. Halliwell, B. & Gutteridge, J.M.C. (2007). Free radicals in biology and medicine. Biosciences,

He, J., Feng, X., Lu, Y., Zhao, B. (2003): Fomlactones A-C, Novel Triterpene Lactones from

Hirasawa, M., Shouji, N., Neta, T., Fukushima, K., Takada, K. (1999). Three kinds of

Inouye, S., Abe, S.h., Yamagushi, H. (2004). Fungal terpenoid Antibiotics and Enzyme

Ishikawa, N.K.; Yamaji, K.; Ishimoto, H.; Miura, K.; Fukushi, Y.; Takahashi, K.; Tahara, S.

mushroom). *International Journal of Antimicrobial Agents*, 11: 151–157. Hirasawa, M.; Shouji, N.; Neta, T.; Fukushima, K.; Takada, K. (1999). Three kinds of bacterial

*International Journal of Antimicrobial Agents*, Vol.11, No.2, pp. 151-157. Hur, J.M.; Yang, C.H.; Han, S.H.; Lee, S.H.; You, Y.O.; Park, J.C.; Kim, K.J. (2004).

antibacterial substances from *Lentinus edodes* (Berk.) Sing. (Shiitake, an edible

substances from Lentinus edodes (Berk) Sing. (Shiitake an edible mushroom).

Antibacterial effect of Phellinus linteus against methicillin–resistant Staphylococcus

Inhibitors. In: Handbook of fungal Biotechnology. Arora D, editor, 2nd ed. New

(2005). Production of enokipodins A,B,C and D: a new group of antimicrobial

*Current Medicinal Chemistry*, Vol.16, No.12, pp. 1543-1560.

*Carbohydrate Research*, 341: 1130–1134.

Vol.83, No.2, (November), pp. 254-256.

*Complementary Medicine*, Vol.12, No.8, pp. 777-789.

Oxford University Press, Oxford, England.

aureus. *Fitoterapia*, Vol.75, pp. 602-605.

York: Marcel Dekker;, pp. 379-400.

Fomes cajanderi. *Journal of Natural Products*, 66: 1249-1251.

3597-3604.

elucidation of a neutral fucogalactan from the mycelium of Coprinus comatus.

phenolic compounds. *Journal of Agricultural and Food Chemistry*, Vo.44, No.8, pp.

rapid microtiter plate assay for measuring the effect of compounds on Staphylococcus aureus membrane potential. Journal of Microbiological Methods,

cultivation development, - selection of strains resistant to Trichoderma viride, search for new active compounds, - factors influencing plasticity in Grifola frondosa. Universite de Neuchatel, Faculte des Sciences, Neuchatel, Switzerland. Grace, G.L.; Yue, K.P.F.; Gary, M.K.; Tse, P.C.L.; Clara, B.S.L. (2006). Comparative Studies of

Various Ganoderma Species and Their Different Parts with Regard to Their Antitumor and Immunomodulating Activities In Vitro. *Journal of Alternative and*  metabolites from mycelial culture of Flammulina velutipes. *Mycoscience,* Vol.46, pp. 39-45.


Antibacterial Agents from Lignicolous Macrofungi 385

Mothana, R.A.A.; Jansen, R.; Julich, W.D. & Lindequist, U. (2000). Ganomycin A and B, new

Negishi, E., Alimardanov, A., Xu, C. (2000): An efficient and stereoselective synthesis of

Orrù, B., A., R., - Fruciano, E. (2002) Giuseppe Brotzu and the Discovery of Cephalosporins.

Park, Y.K., Kim, I.T., Park, H.J., & Choi, J.W. (2004). Anti-inflammatory and Anti-nociceptive

Park, Y.K., Koo, M.H., Ikegaki, M., & Contado JL. (1997). Comparison of the flavonoid

Paterson, R.R.M. (2006). Ganoderma –a therapeutic fungal biofactory. *Phytochemistry,* 67, pp.

Performance Standards for Antimicrobial Susceptibility Testing. (2005). Clinical Laboratory

Pietta, P.G. (2000). Flavonoids as Antioxidants. Reviews. *Journal of Natural Products*; 63, pp.

Puttaraju, N.G., Venkateshaiah, S.U., Dharmesh, S.M., Urs, S.M.N., Somasundaram, R.

Ren, G., Liu, X.Y., Zhu, H.K., Yang, S.Z., Fu, C.X. (2006): Evaluation of cytotoxic activities of some medicinal polypore fungi from China. *Fitoterapia*; 77, pp. 408-410. Ribeiro, B., Valentao, P., Baptista, P., Seabra, R., Andrade, P.B. (2007). Phenolic compounds

Rosa, L.H., Machado, K.M.G., Jacob, C.C., Capelari, M., Rosa, C.A., Zani, C.L. (2003).

Rosecke, J., Pietsch, M., Konig, W.A. (2000). Volatile constituents of wood-rotting

Shiao, M.S. (1992). Triterpenoid Natural Products in the Fungus Ganoderma lucidum.

Shimada M, Akamatsu Y, Tokimatsu T, Mii K, Hattori, T. (1997). Possible biochemical roles

Shittu, O. B., Alofe, F. V., Onawunmi, G. O., Ogundaini, A. O., Tiwalade, T. A. (2006):

(2006). Antioxidant activity of indigenous Edible Mushrooms. *Journal of Agricultural* 

organic acids profiles and antioxidative properties of beefsteak fungus (Fistulina

Screening of Brazilian Basidiomycetes for Antimicrobial Activity. *Memórias do* 

of oxalic acids as a low molecular weight compound involved in brown-rot and

Bioautographic Evaluation of Antibacterial Metabolite Production by Wild

*Journal of Natural Products,* 63, pp. 416-418.

*Phytotherapy Research,* Vol.19, No.4, pp. 310-313.

*Brazilian Archives of Biology and Technology*; 40(1): 97-106.

hepatica). *Food Chemical Toxicology*, 45, pp. 1805-1813.

Basidiomycetes. *Phytochemistry*, 54, pp. 747-750.

Journal of Chinese Chemical Society, 39, pp. 669-674.

white–rot wood decay . *Journal of Biotechnology* 53: 103-113.

Mushrooms. *African Journal of Biomedical Research*, 9: 57 - 62.

Standards Institute CLSI, NSBI , Wayne, USA

*and Food Chemistry* 54, pp. 9764-9772.

*Instituto Oswaldo Cruz*.; 98(7):967-974.

2002, Colonia (Germania).

*Bulletin*; 27(10): 1599-1593.

1985-2001.

1035-1042.

antimicrobial farnesyl hydroquinones from the Basidiomycete Ganoderma pfeifferi.

xerulin via Pd-catalyzed cross coupling and lactonization featuring (E) lodobromoethylene as a novel two-carbon synthon. *Organic Letters,* 2 (1): 65-67. Ngai, P.H.; Zhao, Z. & Ng, T.B. (2005). Agrocybin, an antifungal peptide from edible mushroom Agrocybe cilindracea. *Peptides,* Vol .26, No.2, pp. 191-196. Ofodile, L.N.; Uma, N.U.; Kokubun, T.; Grayer, R.J.; Ogundipe, O.T., Simmonds, M.S.J.

(2005). Antimicrobial activity of some Ganoderma species from Nigeria.

In: 8th European Conference of Medical and Health Libraries, 16-21 Settembre

effects of the Methanol extract of Fomes fomentarius. *Biological* & *Pharmacological* 

aglycone contents of Apis mellifera propolis from various regions of Brazil.

and antoxidant activities of edible and medicinal mushrooms from Korea. *Journal of Agricultural and Food Chemistry*; Vol.56, No.16, pp. 7265-7270.


Kitzberger, C.S.G.; Smania, JrA.; Pedrosa, R.C. & Ferreira S.R.S. (2007). Antioxidant and

solvents and superficial fluids. *Journal of Food Engineering*; 80, pp. 631- 638. Kryger, K.; Sosulski, F. & Hogge, L. (1982). Free, esterified, and insoluble-bound phenolic

Kuhnt, D., Anke, T., Besl, H., Bross, M., Herrmann, R., Mocek, U., Steffan, B., Steglich, W.

Lee, J.S. (2005). Effects of *Fomes fomentarius* supplementation on antioxidant enzyme

Lee, S.Y. & Rhee, H.M. (1990). Cardiovascular effects of mycelium extract of Ganoderma

Lindequist, U.; Niedermeyer, T.H.J. & Julich, W.D. (2005). The pharmacological potential of

Liu, F., Ooi, V.E.C. & Chang, S.T. (1997). Free radical scavenging activities of mushroom

Liu, G.T. (1999). Recent advances in research of pharmacology and clinical application of

Liu, X.T., Winkler, A.L., Schwan, W.R., Volk, T.J., Rott M., Monte A. (2010). Antibacterial

Lo, K.M. & Cheung, C.K. (2005). Antioxidant activity of extracts from the fruiting bodies of

Lorenzen, K. & Anke, T. (1998). Basidiomycetes as a sources for new bioactive natural

Magae, Y. & Ohara, S. (2006): Structure-activity relationship of triterpenoid saponins on

Magan, N. ; Hope, R. ; Cairns, V. & Aldred, D. (2003): Post-harvest fungal ecology: Impact of

Mau, J.L., Lin, H.C., & Chen, C.C. (2002). Antioxidant properties of several medicinal mushrooms. *Journal of Agricultural and Food Chemistry,* 50, 6072-6077.

*Agricultural and Food Chemistry*; Vol.56, No.16, pp. 7265-7270.

acids, *Journal of Agricultural and Food Chemistry,* 30, pp. 330-334.

leukaemia cells. *Journal of Natural Products*, 67, pp. 2008-2011.

polysaccharide extracts. *Life Sciences,* Vol.60, No.10, pp. 763-771.

Agrocybe aegerit var. alba. *Food Chemistry*, 89, pp. 533-539.

products. *Current Organic Chemistry*, 2, pp. 329-364.

Moser, M. Agarisc and Boleti. Stuttgart: Gustav Fisher Verlag, 1978.

*Journal of Medicinal Mushrooms,* 1, pp. 63-67.

*Planta Medica*, 76(5), pp. 464-466.

*Biochemistry* 70: 1979–1982.

*Plant Pathology*, 109, pp. 723–730.

43 (11): 1414-1420.

299.

*Nutritional Research*; 25: 187–195.

and antoxidant activities of edible and medicinal mushrooms from Korea. *Journal of* 

antimicrobial activities of shiitake (Lentinula edodes) extracts obtained by organic

(1990): Antibiotics from basidiomycetes. XXXVII. New inhibitors of cholesterol biosynthesis from cultures of Xerula melanotricha Dörfelt. *The Journal of Antibiotics*,

activities, blood glucose, and lipid profile in streptozotocin-induced diabetic rats.

lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. *Chemical & Pharmacological Bulletin (Tokyo)*; Vol.38, No.5, pp. 1359-1364. Leon, F.; Quintana, J.; Rivera, A.; Estevez, F. & Bermejo, J. (2004). Lanostanoide triterpenes

from Laetiporus sulphureus and apoptosis induction on HL-60 Human myeloid

mushrooms. *Evidence-based Complementary and Alternative Medicine*; Vol.2, No.3, pp. 285-

Ganoderma P. Karst. species (Aphyllophoromycetdeae) in China. *International* 

Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity Against Bacillus cereus Isolated from Fomitopsis pinicola.

fruiting body induction in Pleurotus ostreatus. *Bioscience, Biotechnology and* 

fungal growth and mycotoxin accumulation in stored grain. *European Journal of* 


**19** 

*1Iran* 

*2Czech Republic* 

**Antibacterial Agents in Textile Industry** 

With the growing public health awareness of the pathogenic effects, malodors and stain formations caused by microorganisms, there is an increasing need for antibacterial materials in many application areas like medical devices, health care, hygienic application, water purification systems, hospital, dental surgery equipment, textiles, food packaging, and

The spread of HIV and hepatitis viruses by contact of contaminated materials has created increased pressure for protection of personnel with functional clothing; also, all articles of apparel and home textiles are susceptible to problems of hygiene in normal daily use, for example, socks, sport wear and working clothes as well as mattresses, floor coverings, and shoe linings. Textiles for outdoor use are constantly exposed to the influence of microbes and bacteria. Application of natural antimicrobial agents on textiles dates back to antiquity, when the ancient Egyptians used spices and herbs to preserve mummy warps. Textile goods, especially those made from natural fibers, provide an excellent environment for microorganisms to grow, because of their large surface area and ability to retain moisture. Most textile materials currently used in hospitals and hotels are conductive to cross infection or transmission of diseases caused by microorganisms. Practically every class of chemical compound has been utilized to impart antibacterial activity to textiles. Two different aspects of antimicrobial protection provided by chemical finishes can be distinguished. The first is the protection of the textile user against pathogenic or odour causing microorganisms (hygiene finishes). The second aspect is the protection of the textile itself from damage caused by mould, mildew or rot producing microorganisms. Bacteria are not as damaging to fibres, but can produce some fibre damage, unpleasant odours and a slick, slimy feel. Often, fungi and bacteria are both present on the fabric in a symbiotic relationship. (Heywood,

Substances added to fibres, such as lubricants, antistatics, natural-based auxiliaries (for example size, thickener and hand modifiers) and dirt provide a food source for

**1. Introduction** 

2003; Bellini, 2001)

Corresponding Author

 \*

storage.(Shahidi et al, 2007)

Sheila Shahidi1,\* and Jakub Wiener2 *1Department of Textile, Faculty of Engineering, Islamic Azad University, Arak Branch, Arak,* 

*Technical University of Liberec, Liberec,* 

*2Department of Textile Chemistry, Faculty of Textile,* 

