**C-terminal CGA-derived fragment**

CCA, the C-terminal CGA-derived fragment bCGA418-427 (Figure 3), with a remarkable net charge of -2, displays antifungal activity and belongs to the less abundant anionic AMPs family. It is well conserved during evolution and is homologous to the C-terminal sequence of CGB and the antibacterial peptide SEC (secretolytin) [(Strub et al., 1996b). This peptide was generated *in vitro* after digestion, by the protease Glu-C from *S. aureus*, of the material present in chromaffin secretory vesicles. As previously postulated for CHR, CCA could be generated during infections induced by this pathogen.
