**4. Synergy of the combination of antimicrobial peptides with antibiotics**

The emergence of multi-drug resistant bacteria (MDR), with therapeutic failure against *Staphylococcus aureus* (MRSA), *Klebsiella pneumonia*, *Acinebacter baumannii and Pseudomonas aeruginosa* have paved the way to develop new therapeutic agents by the help of the synergism. In addition the highly toxic effects of antibiotics have shifted the research focus to discover new peptides with broad spectrum of activity and less toxicity. Synergy is the combined activity of two antimicrobial agents that can never be attained by any one of them singly (Serra et al., 1977). Numerous AMPs demonstrate broad spectrum of activity against pathogens, interacting directly with membranes or acting with a specific mode. They represent interesting candidates to synergistically act with antibiotics.
