**1.1 Multidrug antibiotic resistance and innate immunity**

Multidrug-resistant organisms, such as methicillin-resistant *Staphylococcus aureus* (MRSA) and Vancomycin-resistant enterococci (VRE) have important infection control implications in all healthcare stings. Multidrug antibiotic resistance is a worldwide crucial health problem and the production of new potent antibiotics, acting alone or in combination is urgent. In addition, a major factor in the emergence of antibiotic resistant organisms is the overuse of antibiotics in the hospital or the community. To overcome this abuse, numerous efforts are undertaken to reduce antibiotics prescription and/or promote synergistic effects by others molecules.

Indeed, stimulating organism defense is a promising way to struggle against pathogens. The innate immune system is, since 2 billion years, the primary defense in most living organisms and antimicrobial peptides (AMPs) are fundamental components of the innate immune defense of multicellular organisms, either animal or vegetal (Bulet et al., 2004; Aerts et al. 2008; Manners, 2007).
