**1.8 Histidine rich glycoprotein peptides**

Histidine-rich amphipathic cationic peptides are peptides with ¼ of their amino acids represented by histidine. They show a global cationic amphipathic helical structure. They trigger microorganism membrane disruption when the peptide adopts an alignment parallel to the membrane surface. Even though, pore formation is not essential for their high antimicrobial activity (Mason et al., 2009). Clavinin and daptomycin are other studied members of this antimicrobial peptide class. Some Histine rich peptide, like LH4, also have the capability to enhance transfection, a feature that is related to membrane perturbation capability (Georgescu et al., 2010).
