**4.1.1.8** *TMHS* **or LHFPL5 genes in DFNB67 locus**

Non syndromic HL in a Pakistani family linked to a new region on chromosome 6p21.1 p22.3 defining a new locus, DFNB67 in 2006; *TMHS* or *LHFPL5* gene was mapped in this region [Shabbir et al., 2006]. *LHFPL5* has 4 exons and encodes a 2162 nucleotide mRNA and translates into a protein of 219 amino acids. The proposed structure of the protein is a four pass transmembrane domain. Mutations of this gene have been reported in patients from Pakistan and Turkey (C161F, Y127C, P83fsX84). *TMHS* is important for the transmission of sound.
