**10. Acknowledgements**

Our studies introduced in this chapter were supported by Grants-in-aid for Scientific Research from the Japan Society for the Promotion of Science (nos. 20590435, 22590386) and Health and Labour Sciences Research Grants from the Ministry of Health, Labor and Welfare of Japan (H22-Kokui-Shitei-004). I am grateful to Prof. Tamotsu Kanazawa and other laboratory members for their valuable scientific advice. I also acknowledge the technical assistance of Ms. Yukari Horie and the clerical assistance of Ms. Tomoko Fujitomi.
