**3. Major antigenic targets of the anti-myelin autoAbs**

There are extensive information on a significant portion of MS cases, characterized by the presence of autoantibodies against myelin protein components in serum of patients with MS. (Chamczuk et al., 2002; Reindl et al., 1999) Although the mechanism of the autoantibody role in MS pathogenesis is unknown , autoantibodies to MBP and MOG were proposed as biomarkers for clinical prognosis of MS. (Berger et al., 2003) Similar immunoglobulins were also found in mice with induced EAE, which is an animal model of MS. (Fritz et al., 1983)
