**6. Components of the modified vaccine and how it works**

#### **6.1 Target ag against which the desired ab response is required**


#### **6.2 Ab against the disease causing/contributing target ag**


The modified vaccine is composed of an IC mixture made up of the target ag and ab against the target ag in slight ag excess. E.g. in an experimental autoimmune kidney disease (Barabas et al., 2003; Barabas et al., 2004b; Barabas et al., 2006c; Barabas et al., 2006b) it was observed that:

 immunization with suitable IC (rat kidney fraction 3 X rat anti-rat kidney fraction 3 IgM ab) at slight ag excess prior and subsequent to disease-inducing inoculation prevented the occurrence of the autoimmune kidney disease (Barabas et al., 2004b; Barabas et al., 2006b) (prophylactic vaccination);

