**6. Conclusions**

SS is one of the most frequent autoimmune diseases, characterized by the dysregulation of cellular and humoral mechanisms, thereby portraying the prototype of autoimmune disorders. Although, the pathogenesis of SS still remains to be discovered, tremendous progress has been made in deciphering the intrinsic abnormalities behind initiation and perpetuation of inflammation and tissue destruction. The herald of new pathophysiological mechanisms such as epigenetic control may prove cardinal in tailoring new treatments providing improved relief to patients with SS.
