**1. Introduction**

198 Technical Problems in Patients on Hemodialysis

Piccoli A, Rossi B, Pillon L & Bucciante G. (1994) A new method for monitoring body fluid

Piccoli A, Nigrelli S, Caberlotto A, Bottazzo S, Rossi B, Pillon L & Maggiore Q. (1995)

Reddan DN, Szczech LA, Hasselblad V, Lowrie EG, Lindsay RM, Himmelfarb J, Toto RD,

Rupp JW, Stone RA & Gunning BE. (1978) Sodium versus sodium-fluid restriction in

Santos SF & Peixoto AJ. (2008) Revisiting the dialysate sodium prescription as a tool for

Sezer S, Ozdemir FN, Arat Z, Perim O, Turan M & Haberal M. (2002) The association of

Titze J. (2008) Water-free Na+ retention: interaction with hypertension and tissue hydration.

Tomson CR. (2001) Advising dialysis patients to restrict fluid intake without restricting

US Department of Agriculture. Sodium content of selected foods per common measure. http://www.nal.usda.gov/fnic/foodcomp/Data/SR18/nutrlist/sr18a307.pdf

US National Heart, Lung, and Blood Institute. (2006) Your guide to lowering your blood

Van Biesen W, Williams JD, Covic AC, Fan S, Claes K, Lichodziejewska-Niemierko M,

Vilar E, Wellsted D, Chandna SM, Roger N. Greenwood RN & Farrington K. (2009) Residual

World Health Organisation. (2010) Creating an enabling environment for population-based

http://whqlibdoc.who.int/publications/2010/9789241500777\_eng.pdf (accessed

dialysis dose. *Nephrol Dial Transplant,* Vol 24 (2009), pp. 2502–2510.

model. *Nephrol Dial Transplant,* (2011). Epub ahead of print.

Food Standards Agency, United Kingdom, July 2010.

populations. *Am J Clin Nutr,* Vol. 61 (1995), pp. 269–270.

patients. *Clin J Am Soc Nephrol,* Vol. 3 (2008), pp. 522-530.

hemodialysis patients. *Ren Fail,* Vol. 24 (2002), pp. 37-48.

randomized trial. *J Am Soc Nephrol,* Vol. 16 (2005); pp. 2162-2169.

534-539.

(1978), pp. 1952-1955.

(accessed May 2011).

May 2011).

*Blood Purif*, Vol. 26 (2008), pp. 95-9.

new\_dash.pdf (accessed May 2011).

*Transplant*, Vol. 16 (2001), pp. 1538-1542.

variation by bioimpedance analysis: the RXc graph. *Kidney Int,* Vol. 46 (1994), pp.

Bivariate normal values of the bioelectrical impedance vector in adult and elderly

Stivelman J, Winchester JF, Zillman LA, Califf RM & Owen WF Jr. (2005) Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a

hemodialysis: control of weight gains and blood pressures. *Am J Clin Nutr* Vol. 31

better blood pressure and interdialytic fluid gain management in hemodialysis

interdialytic fluid gain with nutritional parameters and mortality risk in

sodium intake is not based on evidence and is a waste of time. *Nephrol Dial* 

pressure with DASH. http://www.nhlbi.nih.gov/health/public/heart/hbp/dash/

Verger C, Steiger J, Schoder V, Wabel P, Gauly A & Himmele R; for the EuroBCM Study Group. (2011) Fluid status in peritoneal dialysis patients: the European Body Composition Monitoring (EuroBCM) study cohort. *PLoS One,* Vol. 6 (2011), e17148. van der Wal WM, Noordzij M, Dekker FW, Boeschoten EW, Krediet RT, Korevaar JC &

Geskus RB; for the NECOSAD Group. (2011). Full loss of residual renal function causes higher mortality in dialysis patients; findings from a marginal structural

renal function improves outcome in incremental haemodialysis despite reduced

salt reduction strategies. Report of a joint technical meeting held by WHO and the

In this review we describe what is recently known about the origin of free nucleic acids in human circulation, which processes can cause the elevations of their total concentrations and the alterations in the ratios among different types of circulating nucleic acids in human plasma and serum. We focus on the inflammatory response and apoptosis with regard to changes in the quantity and quality of circulating nucleic acids pool. We discuss the use of cell-free nucleic acids as biomarkers in patients with renal failure not only in hemodialysis but also in peritoneal dialysis with regard to future perspectives on the field of cell-free nucleic acids.
