**2. Material and methods**

Over the last 30 years (1981-2011), a series of 64 patients (29 boys and 35 girls) have presented with HUS in our hospital. Clinical charts of children with neurological symptoms during the acute phase were reviewed, including:



Neurologic evaluation was performed by a pediatric neurologist when abnormalities at the initial neurological examination or complementary tests were identified.

Neurological sequelae were considered "medium-term" when they were present between 4 weeks and 12 months after clinical onset; complications were considered "long-term" when they persisted for more than 1 year after admission.

Neurocognitive evaluation was performed when medium or long term sequelae were identified. In these patients, physiotherapy and neurocognitive intervention were started as soon as possible after hospital discharge and continued during the school years.


Follow-up was maintained until clinical normalization or at least 2 years after admission.
