**3. Materials and methodes**

This is a prospective study, clinical and genetic, approved by the Ethical Committee, at Medical Faculty of Skopje. The clinical part of the study was made at University Clinic of Neurology in Skopje. Laboratory and genetic part of the study was made at the laboratory of molecular biology at Faculty of Math and Natural sciences at University of "St. Cyril and Methodius" in Skopje.

In the study were included and were analyzed 30 patients. At each of them, Idiopathic Parkinson Disease was diagnosed, by using many diagnostic criteria such as: History of the patient's disease; Neurological examination; Neurophysiologic examinations such as EEG, ENMG, EP (VEP, SEP, BAEP); Neuroimaging methods, such as CT scan and MRI of brain; Neuropsychological tests.
