**8. References**


Human Oscillatory EEG Activities Representing Working Memory Capacity 261

Miller, E.K. & Cohen, J.D. (2001). An integrative theory of prefrontal cortex function. *Annual* 

Miyashita, Y. & Chang, H.S. (1988). Neuronal correlate of pictorial short-term memory in the

Mizuhara, H., Wang, L.Q., Kobayashi, K., & Yamaguchi, Y. (2004). A long-range cortical

Pashler, H. (1994). Dual-task interference in simple tasks: data and theory. *Psychological* 

Passingham, R.E. & Sakai, K. (2004). Working memory: physiology and brain imaging.

Perrin, F., Pernier, J., Bertrand, O., & Echallier, J. F. (1989) Spherical splines for scalp

Phillips W.A. (1974). On the distinction between sensory storage and short-term visual

Postle, B.R. & D'Esposito, M. (1999). Dissociation of human caudate nucleus activity in

Rowe, J.B., Toni, I., Josephs, O., Frackowiak, R.S., & Passingham, R.E. (2000). The prefrontal

Rypma, B., Berger, J.S., & D'Esposito, M. (2002) The influence of working-memory demand

Sauseng, P., Klimesch, W., Schabus, M., & Doppelmayr, M. (2005). Fronto-parietal EEG

Tallon-Baudry, C., Bertrand, O., Delpuech, C., & Pernier, J. (1997). Oscillatory gamma-band

Todd, J.J. & Marois, R. (2004). Capacity limit of visual short-term memory in human

Todd, J.J. & Marois, R. (2005) Posterior parietal cortex activity predicts individual

Varela, F., Lachaux, J. P., Rodriguez, E., & Martinerie, J. (2001) The brainweb: phase

Vogel, E.K. & Machizawa, M.G. (2004). Neural activity predicts individual differences in

Wager, T.D. & Smith, E.E. (2003) Neuroimaging studies of working memory: a metaanalysis. *Cognitive, Affective, & Behavioral Neuroscience,* Vol.3, pp.255-274.

visual working memory capacity. *Nature*, Vol.428, pp. 784-751.

memory. *International Journal of Psychophysiology*, Vol.57, pp. 97-103. Smith, E.E. & Jonides, J. (1999). Storage and executive processes of the frontal lobes. *Science,*

posterior parietal cortex. *Nature,* Vol.428, pp. 751-754.

network emerging with theta oscillation in a mental task. *Neuroreport*, Vol.15, pp.

potential and current density map reading. *Electroencephalography and Clinical* 

spatial and nonspatial working memory: An event-related fMRI study. *Cognitive* 

cortex: response selection or maintenance within working memory? *Science*,

and subject performance on prefrontal cortical activity. *Journal of Cognitive* 

coherence in theta and upper alpha reflect central executive functions of working

(30-70 Hz) activity induced by a visual search task in humans. *Journal of* 

differences in visual short-term memory capacity. *Cognitive, Affective, & Behavioral* 

synchronization and large-scale integration. *Nature Reviews Neuroscience*, Vol.2, pp.

*Review of Neuroscience,* Vol.24, pp.167-202.

*Bulletin*, Vol.116, pp. 220-244.

*Neurophysiology,* Vol.72, pp. 184-187.

*Brain Research,* Vol.8, pp. 107-115.

*Neuroscience,* Vol.14, pp. 721-731.

*Neuroscience*, Vol.17, pp. 722-734.

*Neuroscience,* Vol.5, pp. 144-155.

229-239.

Vol.288, pp. 1656-1660.

Vol.283, pp. 1657-1661.

1233-1238.

primate temporal cortex. *Nature*, Vol.331, pp. 68-70.

*Current Opinion in Neurobiology*, Vol.14, pp. 163-168.

memory. *Perception & Psychophysics*, Vol.16, pp. 283-290.


Delorme, A., & Makeig, S. (2004). EEGLAB: an open source toolbox for analysis of singletrial EEG dynamics. *Journal of Neuroscience Methods,* Vol.134, pp. 9-21. Diwadkar, V.A., Carpenter, P.A. & Just, M.A. (2000). Collaborative activity between parietal

Fuster, J.M. & Alexander, G.E. (1971). Neuron activity related to short-term memory. *Science*,

Funahashi, S., Bruce, C.J., and Goldman-Rakic, P.S. (1989). Mnemonic coding of visual space

Glahn, D.C., Kim, J., Cohen, M.S., Poutanen, V.P., Therman, S., Bava, S., VanErp, T.G.M.,

dissociations in the prefrontal cortex. *Neuroimage,* Vol.17, pp. 201-213. Goldman-Rakic, P.S. (1987). Circuitry of primate prefrontal cortex and regulation of

by fMRI. *Neuroimage*, Vol.12, pp. 85-99.

Vol.173, pp. 652-654.

pp. 331-349.

1399.

1518-1530.

and dorso-lateral prefrontal cortex in dynamic spatial working memory revealed

in the monkey's dorsolateral prefrontal cortex. *Journal of Neurophysiology*, Vol.61,

Manninen, M., Huttunen, M., Lonnquvist, J., Standertskjold-Nordenstam, C.G., & Cannon, T.D. (2002). Maintenance and manipulation in spatial working memory:

behavior by representational memory, In: *Handbook of Physiology*. F. Mountcastle & F. Plum (Eds.), 373-417, American Physiology Society, Washington DC, USA. Jensen, O., & Tesche, C.D. (2002). Frontal theta activity in humans increases with memory

load in a working memory task. *European Journal of Neuroscience,* Vol.15, pp. 1395-

in a working memory task: an event-related functional MRI study. *Journal of* 

parietal cortex maintains color, shape and motion in visual short-term memory.

functions and alpha storage buffers in auditory and visual working memory.

phase synchronization and memory: evidence for control processes in different

& Munk, M.H.J. (2003). Cortical capacity constraints of visual working memory: dissociation of fMRI load effects in a front-parietal network. *Neuroimage*, Vol.20, pp.

Jha, A.P. & McCarthy, G. (2000). The influence of memory load upon delay-interval activity

Kawasaki, M., & Watanabe, M. (2007). Oscillatory gamma and theta activity during repeated mental manipulations of a visual image. *Neuroscience Letters*, Vol.422, pp. 141-145. Kawasaki, M., Watanabe, M., Okuda, J., Sakagami, M., & Aihara, K. (2008). Human posterior

Kawasaki, M., Kitajo, K., & Yamaguchi, Y. (2010). Dynamic links between theta executive

Klimesch, W., Freunberger, R., Sauseng, P., & Gruber, W. (2008). A short review of slow

Kubota, K. & Niki, H. (1971). Prefrontal cortical unit activity and delayed alternation performance in monkeys. *Journal of Neurophysiology*, Vol.34, pp. 337-347. Linden, D.E.J., Bittner, R.A., Muckli, L., Waltz, J.A., Kriegeskorte, N., Goebel, R., Singer, W.,

Logan, G.D. & Gordon, R.D. (2001). Executive control of visual attention in dual-task

Luck, S.J. & Vogel, E.K. (1997). The capacity of visual working memory for features and

Marois, R. & Ivanoff, J. (2005). Capacity limits of information processing in the brain. *Trends* 

*Cognitive Neuroscience,* Vol.12 (Suppl 2), pp. 90-105.

*European Journal of Neuroscience*, Vol.31, pp. 1683-1689.

memory systems? *Brain Research*, Vol.1235, pp. 31-44.

situations. *Psychological Review*, Vol.108, pp. 393-434.

conjunctions. *Nature*, Vol.390, pp. 279-281.

*in Cognitive Sciences*, Vol.9, pp. 296-305.

*Brain Research*, Vol.1213, pp. 91-97.


**13** 

*Italy* 

 **An Updated View** 

*Ospedale Maggiore Policlinico, Milano,* 

**Neuroimaging Data in Bipolar Disorder:** 

Bernardo Dell'Osso, Cristina Dobrea, Maria Carlotta Palazzo,

Laura Cremaschi, Chiara Arici, Beatrice Benatti and A. Carlo Altamura *Department of Psychiatry, University of Milan, Fondazione IRCCS Cà Granda,* 

BD is a prevalent mood disorder, often comorbid with other medical and psychiatric conditions and frequently misdiagnosed (Altamura et al., 2011a). Intense emotional states that occur in BD comprise manic, hypomanic, mixed or depressive episodes. According to the Diagnostic and Statistical Manual of Mental Disorders, IVth edition, text revision (DSM-IV–TR; American Psychiatric Association, 2000), BD spectrum ranges from cyclothymia to Bipolar I, Bipolar II Disorder and Not Otherwise Specified (NOS) forms. BD can also be conceptualized as a gradual change in mood scale, which ranges from severe depression to

Dysthymia is a chronic state of mild low mood occurring for a minimum of two years. At the other end of the scale there is hypomania and severe mania. An alternative and broader dimensional approach conceptualizes BD as a continuum, between unipolar depression, schizoaffective disorder (which is considered by some authors a subcategory of BD) and schizophrenia. This theory may be supported from a clinical point of view by the fact that, sometimes, during severe manic, mixed or depressive episodes, bipolar patients experience psychotic symptoms, such as hallucinations or delusions. It is also supported by the presence of morphometric alterations of frequent observation among major psychoses, such as enlarged ventricles and white matter volume reductions in the left and temporoparietal

In BD, symptomatic states are frequently associated with poor working functioning and social impairment. Bipolar patients, moreover, have higher suicide rates than the general population and among the highest of psychiatric patients. In a recent study on factors predicting suicide in BD, white race, family history of suicide, and previous cocaine abuse were considered predictive of suicidal behaviour (Cassidy, 2011). Usually BD develops in early adulthood/late teens, with an age of onset ranging from 15 to 50 years (Cassano et

International treatment guidelines for BD recommend the use of mood stabilizers - either in monotherapy or in association - as the gold standard in both acute and long-term therapy. The concept of stabilization, in fact, has been stressed as the ultimate objective of the treatment of BD, given the chronic and recurrent nature of the illness, which accounts for its significant levels of impairment and disability (Altamura et al., 2011b). Beyond the

severe mania with an intermediate euthymic state or balanced mood.

**1. Introduction** 

regions (Czobor et al., 2007).

al., 2006).

