*2.1.3 Clinical manifestations of drug-induced aplastic anemia*

The most significant clinical presentation of aplastic anemia is the decline in the count of blood cells and the condition is widely termed as pancytopenia. Aplastic anemia can be clinical characterized by either decrease in one type of blood cells or by the overall decrease of blood cells in most of the cases. Some of the other clinical features are:


## **2.2 Drug-induced agranulocytosis**

This is a clinical condition where there is a decrease in the body's total number of mature myeloid cells (Granulocytes and immature ones) to 500 cells/mm3 or fewer [22–25]. Occurrence of agranulocytosis is mainly seen in females and aged people with an approximated yearly incidence rate of one to 12 cases per 10 lacs population. This hematological condition will generally settle over time with approving care and prevention and management of infection.
