*2.5.2 List of common drugs responsible for hemolytic anemia*


*Drug Induced Hematological Disorders: An Undiscussed Stigma DOI: http://dx.doi.org/10.5772/intechopen.109533*


#### *2.5.3 Clinical features of drug-induced immune hemolytic anemia*

The sign and symptoms resemble the clinical features like anemia, patient may complain of fever with chills and rigor, breathlessness etc.

#### **2.6 Identification of drug-induced hematological disorders**

The adverse event of drug induced hematological disorders are best identified during the clinical use of the suspected drugs. The patients administrating the suspected drug with potential to induce these hematological events should be closely monitored and any suspicious events should be assessed for the causal relationship with the drugs using the causality assessment scale. There are several scales to establish the causal relationship, assess the severity and preventability of the drugs with these adverse effects. The suspected drug should be withdrawn immediately, and the drug should not be rechallenged as these incidences are severe in nature. The suspected adverse drug reactions are then submitted to the local, zonal, or regional pharmacovigilance centers. The reporting can also be done to the competent authorities by their website with the complete information of the events and product.

#### **2.7 Diagnosis tools**

#### *2.7.1 History taking*

The complete and detailed history taking helps in diagnosing most of the cases. The patients usually have the history of taking the medications susceptible to induce these adverse drug reactions.

#### *2.7.2 Monitoring of therapy*

The monitoring of the therapy containing these agents also help in the prevention or early detection of such events.

### *2.7.3 Laboratory findings*

The other mean to diagnose the cases are to obtaining the laboratory report and clinical correlation to the past medication history. The laboratory reports show the decline in the blood cells post commencement of medication therapy. Laboratory tests mainly performed are:

#### *2.7.3.1 Complete blood count (CBC)*

This test measures the levels of platelets and other blood cells in the blood.

#### *2.7.3.2 Blood smear*

A portion of patients' blood is placed on a glass slide under the microscope to observe the platelets.
