**Notes/thanks/other declarations**

Thanks to Jan Schouten for his ongoing support in the medical and science world and providing a pleasant a comfortable working environment. Also thanks the MRC Holland staff for aiding in development, providing feedback and support. A special note to all referenced authors, their valuable work provided insights that helped to try to make sense of it all, without that it was not possible. Thanks to Joost van den Berg for many years of excellent programming work and providing understanding into the world of coding. Very grateful for Lydia de Burger, her unwavering support and unending understanding have made a great difference. If any references were left out, sincere apologies, this work was intended to summarize and attempt to provide some understanding and describe different considerations we went through when developing scientific software. This is also intended to invite discussion, share experiences to implementation of regulations to move forward.
