**3.1.1 Clinical data from the patients**

Clinical data from the patients were collected according the internal protocol that was approved by the University Clinic of Hematology Institutional Review Board. All included patients had to sign a written consent.

### **3.2 Morphology**

The morphology was analyzed by microscopic examination of >500 nonerythroid cells on May Gruenwald Giemza stained air-dried bone marrow smears (Bennet et al,1997; Döhner et al., 2010; Panovska-Stavridis et al., 2008).
