**7. Conclusion**

Overall, our understanding of the relationship between inflammation and cancer has improved greatly since Virchow first made his observation over 150 years ago. The unravelling of signalling pathways shared by cancer and inflammation will provide the focus for future cancer treatment strategies.

#### **8. References**


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**19** 

*Mexico* 

**CD277 an Immune Regulator of** 

*Ciencias Químico Biológicas y Farmacéuticas, Tepic Nayarit,* 

Jose Francisco Zambrano-Zaragoza1,2 et al.\* *1INSERM, UMR 891, CRCM, Institut Paoli-Calmettes,* 

> *Universite Medierranée, Marseille, France 2Universidad Autónoma de Nayarit,*

**T Cell Function and Tumor Cell Recognition** 

Molecules involved in tumor cell recognition are potentially important targets in cancer therapeutics. Therefore, research on the identification of tumor cell antigens as well as, immune-regulatory molecules is essential. The study of new co-stimulatory molecules has attracted special interest due to, their role in activation and/or inhibition of effector function of immune cells. In this chapter, we focused on the study of CD277 and its putative counterreceptor, and their possible role in activation or inhibition of immune cells and recognition

CD277 has been involved in immune cells regulation, because of its role in activating or inhibiting effector, cytokine secretion and cytotoxic functions, depending on the activating conditions of these cells. Moreover, the fact that the stimulation of tumor cell lines with anti-CD277 leave to a better recognition and killing by γδ and αβ T cells lead us to postulate that these molecules is involved also in tumor recognition. We will discuss different aspects of

Classically, the immune response has been divided into innate and adaptive immunity, with distinct properties. The innate immune response uses a small number of receptors that detect a limited set of conserved antigens. Induction of the adaptive immune response involves antigen presenting cells (APC) and T cells (Borghesi & Milcarek, 2007). The interaction between the T cell and the APC is the pivotal step that controls a series of events, including T cell activation, cell division and effector differentiation (Zhu & Chen, 2009). However, recognition of the processed antigenic peptide coupled to Major

 Nassima Messal1, Sonia Pastor1, Emmanuel Scotet3, Marc Bonneville3, Danièle Saverino4, Marcello Bagnasco5, Crystelle Harly3, Yves Guillaume1, Jacques Nunes1, Pierre Pontarotti6,

*1INSERM, UMR 891, CRCM, Institut Paoli-Calmettes, Universite Medierranée, Marseille, France 2Universidad Autónoma de Nayarit, Ciencias Químico Biológicas y Farmacéuticas,Tepic Nayarit, Mexico* 

*3Centre de Recherche en Cancerologie de Nantes Angers, IRT UN, INSERM UMR 892, Nantes France 4Department of Experimental Medicine-Section Human Anatomy, University of Genova, Italy 5Medical and Radio metabolic Therapy Unit, Department of Internal Medicine, University of Genova, Italy 6Université Aix Marseille 1, UMR 6632 Marseille, France* 

**1. Introduction** 

of cancer cells.

\*

Marc Lopez1 and Daniel Olive1

CD277 and its counter-receptor in this chapter.

