Contents


X Contents


**Part 2 Cancer Signaling, Mechanisms and Targeted Therapy 185** 

Contents VII

**Part 4 Inflammation, Immune System, and Cancer 389** 

O'Leary D.P., Neary P.M. and Redmond H.P.

**T Cell Function and Tumor Cell Recognition 411** 

**Natural Killer Cell Receptors and Their Ligands 427**  Zhixia Zhou, Cai Zhang, Jian Zhang and Zhigang Tian

**Abnormalities Using Microwave Radio Thermometry 447** 

Nassima Messal, Sonia Pastor, Emmanuel Scotet, Marc Bonneville, Danièle Saverino, Marcello Bagnasco, Crystelle Harly, Yves Guillaume, Jacques Nunes, Pierre Pontarotti, Marc Lopez and Daniel Olive

Chapter 18 **The Role of Inflammation in Cancer 391**

Jose Francisco Zambrano-Zaragoza,

**Epigenetic Control of Expression of**

**Detection of Breast Tissue Oncological**

Tahir H. Shah, Elias Siores and Chronis Daskalakis

**in Correlations with the Molecular Genetics**

Chapter 23 **Prospective Applications of Microwaves in Medicine 507** Jaroslav Vorlíček, Barbora Vrbova and Jan Vrba

> **for Leukemia Transplantation Therapy: Rationale and Technique Options 533**

Kathryn Howell, Daniel Chin and Luann Roads

Chapter 25 **Radio-Photoluminescence Glass Dosimeter (RPLGD) 553**

David Y.C. Huang and Shih-Ming Hsu

**Myeloid Leukemia: Single Center Experience 477**

**Analyses for Diagnostic and Clinical Stratification of Patients with Acute** 

**Part 5 Cancer Diagnostic Technologies 445**

Chapter 22 **Immunophenotyping of the Blast Cells**

Irina Panovska-Stavridis

Chapter 24 **Photon Total Body Irradiation**

Brent Herron, Alex Herron,

Chapter 19 **CD277 an Immune Regulator of** 

Chapter 20 **Transcription Regulation and** 

Chapter 21 **Non-Invasive Devices for Early** 

	- **Part 3 Promising Anticancer Plants 343**

#### **Part 4 Inflammation, Immune System, and Cancer 389**

Chapter 18 **The Role of Inflammation in Cancer 391**  O'Leary D.P., Neary P.M. and Redmond H.P.

VI Contents

Chapter 8 **Brain Metastases: Biology and**

**Comprehensive Strategy from Radiotherapy to Metabolic Inhibitors and Hyperthermia 161**

Chapter 9 **Survivin: Identification of Selective Functional Signaling Pathways inTransformed Cells and Identification of a New Splice Variant with Growth Survival Activity 187**

Chapter 10 **Signalling Pathways Leading to TRAIL Resistance 201** 

Alfonso Colombatti and Maurizio Mongiat

Chapter 13 **Targeting Tumor Perfusion and Oxygenation** 

Katsuya Sakai, Takahiro Nakamura, Yoshinori Suzuki and Kunio Matsumoto

Chapter 14 **Significance, Mechanisms, and Progress** 

**Part 3 Promising Anticancer Plants 343**

Chapter 17 **Salograviolide A: A Plant-Derived** 

Chapter 16 **Anticancer Properties of Curcumin 345** 

Varisa Pongrakhananon and Yon Rojanasakul

**Sesquiterpene Lactone with Promising** 

Isabelle Fakhoury and Hala Gali-Muhtasib

**Anti-Inflammatory and Anticancer Effects 369**

Chapter 15 **Nuclear Survivin:** 

Sally P. Wheatley

Bénédicte F. Jordan and Pierre Sonveaux

Chapter 11 **Therapeutical Cues from the Tumor Microenvironment 227** Stefano Marastoni, Eva Andreuzzi, Roberta Colladel, Alice Paulitti, Alessandra Silvestri, Federico Todaro,

> **Targets for Cancer Therapy and Imaging 265** Franziska Graf, Frank Wuest and Jens Pietzsch

> **Modulates Hypoxia and Cancer Sensitivity to Radiotherapy and Systemic Therapies 289**

> **of Anticancer Drugs Targeting HGF-Met 313**

**Cellular Consequences and Therapeutic Implications 333** 

Louis M. Pelus and Seiji Fukuda

Roberta Di Pietro

Chapter 12 **Cyclin-Dependent Kinases (Cdk) as** 

**Part 2 Cancer Signaling, Mechanisms and Targeted Therapy 185**

Baronzio Gianfranco, Fiorentini Giammaria Guais Adeline and Schwartz Laurent

> Chapter 19 **CD277 an Immune Regulator of T Cell Function and Tumor Cell Recognition 411**  Jose Francisco Zambrano-Zaragoza, Nassima Messal, Sonia Pastor, Emmanuel Scotet, Marc Bonneville, Danièle Saverino, Marcello Bagnasco, Crystelle Harly, Yves Guillaume, Jacques Nunes, Pierre Pontarotti, Marc Lopez and Daniel Olive

Chapter 20 **Transcription Regulation and Epigenetic Control of Expression of Natural Killer Cell Receptors and Their Ligands 427**  Zhixia Zhou, Cai Zhang, Jian Zhang and Zhigang Tian


#### Chapter 25 **Radio-Photoluminescence Glass Dosimeter (RPLGD) 553**  David Y.C. Huang and Shih-Ming Hsu

Preface

The book "Advances in Cancer Therapy" is a new addition to the Intech collection of books and aims at providing scientists and clinicians with a comprehensive overview of the state of current knowledge and latest research findings in the area of cancer therapy. For this purpose research articles, clinical investigations and review papers that are thought to improve the readers' understanding of cancer therapy developments and/or to keep them up to date with the most recent advances in this field have been included in this book. With cancer being one of the most serious diseases of our times, I am confident

The participating authors have been selected from diverse countries based solely on their expertise and the appropriateness of their work to the book's topics listed in the table of contents. The authors have all willingly accepted our invitation to submit their chapters for review of their quality. The proposed drafts, consisting of original drafts only, were revised by the book's editor before making the final decision of acceptance or refusal. At this point of the process, some chapters were directly accepted or rejected, while others were sent back for revision according to the editor's recommendations to be later

The publication here presented is unique in its content that covers various subjects from alternative traditional medicine, specifically natural compounds' therapeutic potentials to nanotechnology advances and applications in cancer treatment. All information presented is organized, clear and based on solid scientific facts. This book is therefore destined to all cancer researchers or therapists and it also represents a

With this book compilation the readers will not only find an overview of the big picture of cancer targets and targeting methods that are currently known, but also be aware of exactly where we stand today in the curing of cancer and what needs to be done further. Hopefully, this will all be accomplished during a pleasant enjoyable

**Dr. Hala Gali‐Muhtasib**

Lebanon

Department of Biology, American University of Beirut,

that this book will meet the patientsʹ, physiciansʹ and researchersʹ needs.

accepted after ensuring that they fulfill all the criteria of selection.

valuable addition to any scientific library.

reading of this simply written book accessible to all.
