**3. Conclusion**

Immune responses can be regulated by CD277 in different ways. CD277 affects different immune cells in various ways including inhibition of proliferation, regulation of cytokine secretion in CD4+ and CD8+ T cells, as well as activating monocytes and iDC. Moreover, CD277 promotes the expression of its counter-receptor and this effect may be important for recognition of leukaemia and solid tumor cells.

Proteomics and production and use of monoclonal antibodies are two different approaches we have tested to determine the identity of the CD277 counter-receptor.. However, although functional analysis of CD277 and its counter-receptor has demonstrated a biological effect, it is necessary to identify the counter-receptor and elucidate the signalling pathways involved in the observed response.
