**5.1 Normothermic** *ex-vivo* **heart perfusion**

Organ Care System (**Figure 2**) is a portable device with a wireless display monitor. This device consists of a pulsatile pump connected to a gas exchanger and heater which perfuses blood, nutrient solutions and supplements to the organ inside the perfusion module. The PROCEED II was a multicentre randomized trial performed

#### **Figure 2.**

*Normothermic ex-vivo heart preservation, organ care system (OCS) is composed of a portable heart console (A), heart perfusion module (B) and heart solution set (C). The ascending aorta and pulmonary artery are cannulated. The left ventricular vent is placed and secured at the left atrium. The superior vena cava, inferior vena cava, right atrial incision and left atrial appendage are securely closed. The heart is actively beating inside the box (D). This picture has been reproduced by permission of TransMedics (Andover, MA).*

*Heart Preservation Techniques for Transplantation DOI: http://dx.doi.org/10.5772/intechopen.113937*

in the United States comparing outcomes of the OCS and traditional cold storage, extended criteria donors were excluded. The study showed no significant differences in 30-day mortality, severe graft rejection, ICU stay or cardiac-related complications [33]. At 2 years, the OCS group had a lower survival compared to traditional cold storage but was not statistically different (72.2 vs. 81.6%, p = 0.38). There were no significant differences in major serious cardiac events, graft rejection and chronic vasculopathy at 2 years [34].
