**6. Research funding**

The first-in-human study (https://jrct.niph.go.jp/en-latest-detail/ jRCTs042180025) was funded by the Terumo Foundation for Life Science and Arts.

The investigator-initiated feasibility study is funded by the Japan Agency for Medical Research and Development, Translational Research (https://jrct.niph.go.jp/ en-latest-detail/jRCT2042210157).
