**1. Introduction**

Implantable left ventricular assist devices (LVADs) have become an integral part of the therapeutic arsenal for managing end-stage heart failure [1, 2]. Whether serving as a bridge to transplantation or as a long-term solution, the success of these devices is critically dependent on the appropriate placement of their components, primarily the inflow cannula and the outflow graft. This chapter reviews the standard and alternative placement sites for these vital components of contemporary continuous-flow LVADs.
