**1. Introduction**

144 Advances in the Biology, Imaging and Therapies for Glioblastoma

[16] Bernas LM, Foster PJ, Rutt BK. Imaging iron-loaded mouse glioma tumors with bSSFP at 3 T. Bernas LM, Foster PJ, Rutt BK. Magn Reson Med. 2010 Jul;64(1):23-31. [17] Ribot EJ, Martinez-Santiesteban FM, Simedrea C, Steeg PS, Chambers AF, Rutt BK,

Imaging at 1.5 T. J Magn Reson Imaging 2011 Jul;34(1):231-8.

Foster PJ, In Vivo Single Scan Detection of Both Iron-Labeled Cells and Breast Cancer Metastases in the Mouse Brain Using Balanced Steady-State Free Precession

> Microdialysis is a technique that may be used to directly investigate brain chemistry in-vivo. Although initially developed over 35 years ago (Ungerstedt and Pycock 1974), it is only relatively recently that studies have begun to utilise microdialysis in patients with glioma and other brain tumours. In this chapter we will review the general principles of microdialysis, the use of the technique to investigate glioma pathogenesis and evaluate chemo- and radiotherapy, and the potential utilisation of retrograde microdialysis to administer chemotherapeutic agents directly to the tumour bed.
