**Meet the editor**

Dr. Clark C. Chen received his B.S. from Stanford University in 1992, M.S. from Columbia University in 1993, and his M.D.-Ph.D. from Harvard Medical School in 2001. He completed his neurosurgery training at the Massachusetts General Hospital and subsequently completed independent fellowships in stereotactic neurosurgery and radiosurgery. Dr. Chen previously served as the director of

Clinical Neuro-Oncology at the Beth Israel Deaconess Medical Center before his current role as the Director of Stereotactic and Radiosurgery and Co-Director of Surgical Neuro-Oncology at the University of California, San Diego. Dr. Chen's research is directed at identifying alterations in DNA repair pathways as they relate to brain cancer therapy. Dr. Chen is the recipient of the Damon Runyon Fellowship Award, the James Kerr Award, American Brain Tumor Association Investigator Award, Paul Calabresi Scholar Award, Burroughs Wellcome Career Award, William Guy Forbeck Scholar Award, the Doris Duke Clinical Scientist Award and the Kimmel Scholar Award.

Contents

**Preface IX** 

**Part 1 Biology of Malignant Gliomas 1** 

Chapter 1 **Radiobiology of Radioresistant Glioblastoma 3** 

Chapter 2 **Impact of Metabolic and Therapeutic Stresses on Glioma Progression and Therapy 23**  Kathryn J. Huber-Keener and Jin-Ming Yang

Chapter 3 **Key Principles in Glioblastoma Therapy 53**  Bartek Jiri Jr., Kimberly Ng, Bartek Jiri Sr., Santosh Kesari, Bob Carter and Clark C. Chen

Chapter 5 **Prognostic Significance of Immunohistochemical Markers in Glioma Patients 77** 

Chapter 6 **Gray or White? – The Contribution of Gray Matter in a Glioma to Language Deficits 107** 

**Part 2 Novel Imaging and Diagnostic Modalities 123** 

Chapter 7 **3D TrueFISP MRI Provides Accurate Longitudinal** 

Chapter 8 **Clinical Microdialysis in Glioma 145**  Hani Marcus and Dipankar Nandi

Ryuta Kinno, Yoshihiro Muragaki and Kuniyoshi L. Sakai

**Measurements of Glioma Volumes in Mice 125** 

Emeline Julie Ribot, Line Pourtau, Philippe Massot, Pierre Voisin, Eric Thiaudiere, Jean- Michel Franconi and Sylvain Miraux

Chapter 4 **Biological Responses of Glioma Cell to Chemotherapeutic Agents 61**  Yuichi Hirose and Shigeo Ohba

Tadej Strojnik

Jerry R. Williams, Daila S. Gridley and James M. Slater
