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**16** 

*Takatsuki, Osaka* 

*Kumatori, Osaka* 

*Japan* 

**Clinical Study on Modified Boron** 

**Neutron Capture Therapy for** 

*1Department of Neurosurgery, Osaka Medical College,* 

*2Kyoto University Research Reactor Institute,* 

**Newly Diagnosed Glioblastoma** 

Shinji Kawabata1,\*, Yoko Matsushita1, Motomasa Furuse1, Shin-Ichi Miyatake1, Toshihiko Kuroiwa1 and Koji Ono2

Boron neutron capture therapy (BNCT) is based on the nuclear capture and fission reactions that occur when non-radioactive boron-10 (10B) is irradiated with neutrons of the appropriate energy to yield high energy alpha particles (4He) and recoiling lithium-7 (7Li) nuclei. Since these particles have pathlengths of approximately one cell diameter, their lethality primarily is limited to boron containing cells. BNCT, therefore, can be regarded as both a biologically and a physically targeted type of radiation therapy (Fig. 1). Its success is dependent upon the selective delivery of sufficient amounts of 10B to cancer cells with only small amounts localized in the surrounding normal tissues. A wide variety of boron delivery agents have

Fig. 1. The principle of boron neutron capture therapy (BNCT).

**1. Introduction** 

