**2. Current SRS approaches for glioma**

However the SRS is a relatively young treatment modality, over 400.000 patients were treated with gamma knife all around the world. Currently, there are sufficient data proving the efficacy of SRS on lesions such as arterio-venous malformations, acoustic schwannomas, trigeminal neuralgia and skull base meningiomas. Indications for SRS in gliomas are not definite yet because of the lack of large randomized clinical trials, and multiplicity of gliomas subtypes despite the widespread use (Rejis, 2009).
