**2.3 Radiation effecting dendritic cells DC function**

It has been demonstrated that the radiation modulation of MHC-I mediated antitumor immunity also depends on the antigen presenting pathways of the dendritic cells (Liao, et al. 2004). The dendritic cells either initiate an effective cytotoxic response against antigenbearing cells, or produce tolerance, depending on the context in which those antigens are presented (Zou 2005). It has been shown that cell death caused by radiation therapy release tumour antigen, which facilitates an effective cytotoxic response of the dendritic cells (Hatfield, et al. 2005). Radiation therapy activation of dendritic cells (DC), induce secretion of interleukin-1 beta (IL-1), which is required for the adequate polarization of IFN producing CD8(+) T-cells (Aymeric, et al. 2010).
