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**7** 

*1,3France 2Canada* 

**3D TrueFISP MRI Provides Accurate** 

Emeline Julie Ribot1,2, Line Pourtau1,3, Philippe Massot1,3, Pierre Voisin1,3,

Eric Thiaudiere1,3, Jean- Michel Franconi1,3 and Sylvain Miraux1,3

*3Laboratory of Excellence TRAIL, Translational Research and Advanced Imaging* 

One of the most common models used in pre-clinical studies is nude mice implanted with brain tumors. In fact, owing to a deficiency in their immune systems, nude mice allow many tumor models to be studied and a wide range of therapeutic treatments to be

The best way to evaluate the efficiency of a treatment is to compare the kinetics of the tumor volume between a control group and a treatment group [1-3]. Since brain tumors generally evolve very quickly (7 to 15 days) in mice, the tumor must be detected early and

The advantages of non-invasive imaging methods are evident compared with conventional methods such as histochemistry, where animal sacrifice, end-point analysis only, and 2D

However, obtaining images of high spatial resolution and high contrast for the same animal

As in clinical MR imaging, the tumor can be detected in two possible ways. The first consists of using a gadolinium-based contrast agent injected intravenously to visualize the breakdown of the blood–brain barrier. Using a T1-weighted 3D gradient-echo sequence, high-resolution images can be obtained in a reasonable acquisition time. Nevertheless, because of the injuries caused by repeated injection of contrast agent into the tail vein, experiments cannot be performed frequently [1]. The other way consists of using T2 weighted sequences. RARE imaging, with or without magnetization transfer preparation [3– 5], allows small tumors to be detected noninvasively. The sequence is usually acquired in multi-slice 2D imaging in order to limit the total acquisition time. However, high-resolution,

**1. Introduction** 

investigated.

characterized daily.

tumor-diameter measurement are mandatory.

in a longitudinal study is not trivial.

**Longitudinal Measurements of** 

*1Centre de Résonance Magnétique des Systèmes Biologiques,* 

*2Imaging Research Laboratories, Robarts Research Institute,* 

**Glioma Volumes in Mice** 

*Université Bordeaux Segalen, CNRS* 

*The University of Western Ontario* 

*Laboratory, University of Bordeaux* 
