Contents

### **Preface XII**


	- **Part 2 Novel Imaging and Diagnostic Modalities 123**

Contents VII

Chapter 20 **Ultrafractionated Radiation Therapy (3 Daily Doses**

Patrick Beauchesne

Chapter 21 **Immunotherapy for Malignant Gliomas: A Roadmap for the Future 413** S. De Vleeschouwer and SW. Van Gool

**Schedule for Glioblastoma Patients 397** 

**of 0.75 Gy) - A New and Promising Radiotherapy** 

	- **Part 3 Therapeutic Advances 273**

VI Contents

Chapter 9 **PET Imaging of Gliomas 159** 

Rainer Ritz

Jens Schittenhelm

**Part 3 Therapeutic Advances 273**

Aditya Bansal, Terence Z. Wong and Timothy R. DeGrado

Chapter 10 **Visualization and Photodynamic Therapy in Malignant Glioma - An Overview and Perspectives 183**

Pilar López-Larrubia, Eva Cañadillas-Cárdenas,

Ana M. Metelo, Nuria Arias, Miguel Martínez-Maestro,

**Magnetic Resonance Imaging Techniques 251** 

Andrea Talacchi, Giovanna Maddalena Squintani,

Rheal A. Towner, Ting He, Sabrina Doblas and Nataliya Smith

Barbara Santini, Francesca Casagrande, Francesco Procaccio, Franco Alessandrini, Giada Zoccatelli, Vincenzo Tramontano,

**Therapy for Newly Diagnosed Glioblastoma 325**  Shinji Kawabata, Yoko Matsushita, Motomasa Furuse, Shin-Ichi Miyatake, Toshihiko Kuroiwa and Koji Ono

Chapter 11 **Diagnostic Evaluation of Diffuse Gliomas 199** 

Chapter 12 **Magnetic Resonance Imaging of Gliomas 225** 

Aire Salguero and Sebastián Cerdán

Chapter 13 **Assessment of Rodent Glioma Models Using** 

Chapter 14 **Stereotactic Radiosurgery for Gliomas 275** Mehmet Tönge and Gökhan Kurt

**Glioma in Eloquent Areas 295** 

Aurel Hasanbelliu and Massimo Gerosa

Chapter 17 **Multimodal Approach to the Surgical Removal** 

Sergio Duca and Pietro Versari

Bertil R.R. Persson

**of Gliomas in Eloquent Brain Regions 339**  Giannantonio Spena, Antonio Pepoli, Marcella Bruno, Federico D'Agata, Franco Cauda, Katiuscia Sacco,

Chapter 18 **Radiation Immune Modulation Therapy of Glioma 363** 

Chapter 19 **Confocal Neurolasermicroscopy - Modern Perspectives for Glioma Resection on a Cellular Level 387** Hans-Georg Schlosser and Christian Bojarski

Chapter 16 **Clinical Study on Modified Boron Neutron Capture** 

Chapter 15 **Surgical Treatment of Supratentorial** 

Preface

devastating disease of glioblastoma.

Glioblastoma remains one of the deadliest of human cancers, with almost uniform fatality of those afflicted. Any potential hope of improved clinical outcome would necessarily be grounded in advances in tumor imaging as it relates to biologic tenets and therapeutic strategies. It is in this context that this compendium is assembled. The selected articles are meant to highlight novel paradigms in hopes of stimulating thoughts that may ultimately contribute to meaningful improvement in clinical outcome. Emphasis was placed on key concepts as they relate to clinical translation. I hope that the work will contribute to the collective effort to ultimately cure the

> **Clark C. Chen, M.D., Ph.D.**  University of California,

> > San Diego USA
