**5. Conclusions**

In summary, the synthesis of phyto-metallic nanoparticles is a paradigm shift and preferred approach to conventional environmentally unfriendly and unsustainable nanodrugs. Tremendous efforts are being made to combine the principle of green chemistry and nanotechnology for application in nanomedicine. Phytochemistry and drug development from phytochemicals functionalized on metal nanoparticles have been revisited. Factors like morphology of nanoparticles, time, temperature and pH are identified as critical in the synthesis and therapeutic applications of phyto-metallic nanoparticles. Reviews of several scientific results that compared the effectiveness of phytomediated nanoparticles with their separate phytochemicals, and separate

*Phyto-Metallic Nanoparticles: Biosynthesis, Mechanism,Therapeutics, and Cytotoxicity DOI: http://dx.doi.org/10.5772/intechopen.112382*

metallic nanoparticles as potential therapeutic agents favored phytomediated nanoparticles. A more definitive conclusion on the subject will unfold with further investigations. This chapter gives current insights into the green biogenic synthesis of nanoparticles, mechanisms, therapeutic applications, uptake, and cellular toxicity.
