**Abstract**

The performance of the microfluidic biosensor with integrated flow confinement for the detection of SARS-CoV-2 was analyzed numerically by the finite element method. First, the numerical model was validated by comparison with experimental data reported in the literature. Then, the influence of some parameters on the binding reaction was investigated, such as the flux confinement rate and the amount of analyte supplied to the microchannel inlet. Results showed that flow confinement enhances the convection and diffusion transport of target analytes to the reaction surface and significantly reduces device detection time as well as target sample consumption.

**Keywords:** biosensor, SARS-CoV-2, flow confinement, detection time, microfluidic biosensor
