**5. Conclusion**

DNA-repair proteins are necessary for genome integrity. Their main functions are to control DNA repair and control the cell-cycle checkpoint. Recent studies have not clarified the role of DNA damage repair proteins in centrosome maintenance, although interactions between DNA-repair proteins and centrosomal proteins may have an important role in centrosome maintenance and microtubule regulation such as ATM/ATR-dependent CEP63 phosphorylation. How these interactions contribute to centrosome maintenance and microtubule regulation is unclear, so investigating the relationship between DNA-repair proteins and centrosomal proteins is important. Furthermore, the linkage between centrosome amplification and tumorigenesis is key to developing clinical targets. Inhibitors of the DNArepair protein PARP-1 and the centrosomal protein Aurora A could be a focus for anticancer drugs. Investigations into the molecular signaling pathway of DNA-repair proteins during centrosome maintenance may contribute to advanced options for clinical therapeutics.
