**4.8 Other DNA-repair-related proteins**

TopBP1, a sensor protein involved in the DNA damage response, localizes at the centrosome during mitosis but not at interphase (Bang et al., 2011). TopBP1 interacts with the centrosome through its C-terminus and eliminates TopBP1 localization, resulting in a delay in mitotic progression. SMC1, a condensin protein important during chromosome condensation, also localizes at the centrosome but its role in centrosome maintenance is unclear.

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