**3. Unbiased assessment of transcription factor binding sites in two subgroups of genes from DNA repair pathways**

The research reported in (Yang et al. 2007) provides strong evidence that a unique set of regulatory proteins control genes that contain bidirectional promoters by comparing coexpression clusters of genes enriched for bidirectional promoters versus those depleted for bidirectional promoters. This section reports on a study that identified transcription factor binding sites that are specific to genes in DNA repair pathways (Lichtenberg et al. 2009). The promoters of genes from the DNA repair pathways were partitioned into two groups, those that are bidirectional (32 promoters) and those that are unidirectional (42 promoters).
