**5.8 TFE3**

Studies of the p68 promoter have shown that transcription factor E3 (TFE3) operates in a similar manner to YY1. Thus, the E Box bound by TFE3 and the E2F consensus sequence occur in close proximity in the *p68* promoter. TFE3 and E2F-3 bind to those sites cooperatively (Giangrande et al., 2003; Giangrande et al., 2004). This interaction requires E2F-3, but not TFE3 binding to DNA. Although a direct interaction between these two proteins was not be demonstrated, these two factors likely work together in a larger protein complex, or interact temporarily to recruit one another to the *p68* promoter.
