**Part 2 Mechanistic Insights 173**  Chapter 9 **Role of RPA Proteins in Radiation Repair and Recovery 175**  Patrick E. Gygli, J. Scott Lockhart and Linda C. DeVeaux Chapter 10 **Recognition and Repair Pathways of Damaged DNA in Higher Plants 201**  Sascha Biedermann, Sutton Mooney and Hanjo Hellmann Chapter 11 **DNA Damage Protection and Induction of Repair by Dietary Phytochemicals and Cancer Prevention: What Do We Know? 237**  Alice A. Ramos, Cristóvão F. Lima and Cristina Pereira-Wilson Chapter 12 **The Nuclear Compartmentation of Glutathione: Effect on Cell Cycle Progression 271**  Jelena Markovic, Nancy Mora, Amparo Gimeno, Consuelo Burguete, José Luis García-Gimenez and Federico V. Pallardó Chapter 13 **Role for PKCδ on Apoptosis in the DNA Damage Response 293**  Kiyotsugu Yoshida Chapter 14 **New Players in Recognition of Intact and Cleaved AP Sites: Implication in DNA Repair in Mammalian Cells 305**  Svetlana Khodyreva and Olga Lavrik **Part 3 Methods in DNA Repair 331**  Chapter 15 **SiDNA and Other Tools for the Indirect Induction of DNA Damage Responses 333**  Maria Quanz, Amélie Croset and Marie Dutreix Chapter 16 **DNA Repair in Pathogenic Eukaryotic Cells: Insights from Comparative Genomics of Parasitic Protozoan 369**  Laurence A. Marchat, Mavil López-Casamichana, Esther Orozco and César López-Camarillo Chapter 17 **Mechanisms of Mutagenic DNA Nucleobase Damages and Their Chemical and Enzymatic Repairs Investigated by Quantum Chemical Methods 389**  Eric A. C. Bushnell, Jorge Llano, Leif A. Eriksson and James W. Gauld **Part 4 Insights into Therapeutic Strategies 415**  Chapter 18 **DNA Radiosensitization: The Search for Repair Refractive Lesions Including Double Strand Breaks and Interstrand Crosslinks 417**  Tsvetan G. Gantchev, Marie-Eve Dextraze and Darel J. Hunting

Contents VII

Chapter 19 **The Influence of Individual Genome Sensitivity in DNA** 

Chapter 20 **Application of Host Cell Reactivation in Evaluating the** 

**of DNA Damage and Modulation of DNA** 

Pavel Lobachevsky, Alesia Ivashkevich, Olga A. Martin and Roger F. Martin

Yi-Shan Tsai, Jau-Ling Huang and Chang-Shen Lin

**Repair After Exposure to Gamma-Radiation 483**

Mirta Milić, Ružica Rozgaj, Vilena Kašuba,

Chapter 21 **Role of Radioprotectors in the Inhibition** 

Chapter 22 **DNA-Binding Radioprotectors 497**

Chapter 23 **DNA Damage Response and Repair:** 

**Feverfew PFE Reduces DNA** 

Chapter 26 **Enhancing DNA Repair by Combining only** 

Chapter 24 **The Botanical Extract**

Chapter 25 **Food Factors and Oxidative** 

Ronald W. Pero

**Damage Repair Assessment in Chronic Professional Exposure to Low Doses of Ionizing Radiation 437** 

Ana Marija Jazbec, Patrizia Hrelia and Sabrina Angelini

**Effects of Anticancer Drugs and Environmental Toxicants on Cellular DNA Repair Activity in Head and Neck Cancer 465**

Dharmendra Kumar Maurya and Thomas Paul Asir Devasagayam

**Insights into Strategies for Radiation Sensitization 519** 

Joshua D. Lawson, Kristopher T. Kahle, Kimberly Ng, Bob Carter, Santosh Kesari and Clark C. Chen

**Damage and Induces DNA Repair Processes 531**  Michael D. Southall, Simarna Kaur and Khalid Mahmood

**DNA Damage / DNA Repair Systems 547** Takeshi Hirano and Kazuyoshi Tamae

**Dietary Supplement Ingredients that do not** 

**Metabolically Compete in Order to Achieve Synergism 561**


VI Contents

**Part 2 Mechanistic Insights 173** 

Chapter 10 **Recognition and Repair Pathways**

Chapter 13 **Role for PKCδ on Apoptosis** 

Kiyotsugu Yoshida

**Part 3 Methods in DNA Repair 331** 

Chapter 15 **SiDNA and Other Tools for the Indirect** 

Chapter 11 **DNA Damage Protection and Induction** 

Chapter 9 **Role of RPA Proteins in Radiation Repair and Recovery 175**  Patrick E. Gygli, J. Scott Lockhart and Linda C. DeVeaux

Sascha Biedermann, Sutton Mooney and Hanjo Hellmann

Alice A. Ramos, Cristóvão F. Lima and Cristina Pereira-Wilson

Jelena Markovic, Nancy Mora, Amparo Gimeno, Consuelo Burguete, José Luis García-Gimenez and Federico V. Pallardó

**of Damaged DNA in Higher Plants 201**

**of Repair by Dietary Phytochemicals and Cancer Prevention: What Do We Know? 237**

Chapter 12 **The Nuclear Compartmentation of Glutathione: Effect on Cell Cycle Progression 271** 

**in the DNA Damage Response 293** 

Svetlana Khodyreva and Olga Lavrik

Chapter 14 **New Players in Recognition of Intact and Cleaved AP Sites: Implication in DNA Repair in Mammalian Cells 305**

> **Induction of DNA Damage Responses 333**  Maria Quanz, Amélie Croset and Marie Dutreix

Laurence A. Marchat, Mavil López-Casamichana, Esther Orozco and César López-Camarillo

**Damages and Their Chemical and Enzymatic** 

**The Search for Repair Refractive Lesions Including Double Strand Breaks and Interstrand Crosslinks 417**  Tsvetan G. Gantchev, Marie-Eve Dextraze and Darel J. Hunting

**from Comparative Genomics of Parasitic Protozoan 369** 

**Repairs Investigated by Quantum Chemical Methods 389**

Chapter 16 **DNA Repair in Pathogenic Eukaryotic Cells: Insights** 

Chapter 17 **Mechanisms of Mutagenic DNA Nucleobase**

Eric A. C. Bushnell, Jorge Llano, Leif A. Eriksson and James W. Gauld

Chapter 18 **DNA Radiosensitization:** 

**Part 4 Insights into Therapeutic Strategies 415**


Preface

In previous decades, we have seen a rapid advancement in our fundamental understanding of DNA repair, as well as translational application to medicine in general. In this context, a comprehensive review of key concepts in DNA repair is well beyond the scope of the presented text. Instead, select topics pertinent to the field are

This book is divided into 26 chapters, and compartmentalized into four parts: DNA Damaging Agents, Mechanistic Insights, Methods in DNA Repair, and Insights into Therapeutic Strategies. Each component discusses key concepts in DNA repair. Selected articles are further meant to demonstrate how scientific ideas are developed, tested, dialogued and matured. It is my sincere hope that the articles presented will stimulate and inspire thoughts that, in turn, contribute to this critically important field.

> **Clark C. Chen, M.D., Ph.D.**  University of California, San Diego

> > USA

selected for presentation, with the goal of highlighting paradigmatic advances.
