**Meet the editor**

Dr. Clark C. Chen received his B.S. from Stanford University in 1992, M.S. from Columbia University in 1993, and his M.D.-Ph.D. from Harvard Medical School in 2001. He completed his neurosurgery training at the Massachusetts General Hospital and subsequently completed independent fellowships in stereotactic neurosurgery and radiosurgery. Dr. Chen previously served as

the director of Clinical Neuro-Oncology at the Beth Israel Deaconess Medical Center before his current role as the Director of Stereotactic and Radiosurgery and Co-Director of Surgical Neuro-Oncology at the University of California, San Diego. Dr. Chen's research is directed at identifying alterations in DNA repair pathways as they relate to brain cancer therapy. Dr. Chen is the recipient of the Damon Runyon Fellowship Award, the James Kerr Award, American Brain Tumor Association Investigator Award, Paul Calabresi Scholar Award, Burroughs Wellcome Career Award, William Guy Forbeck Scholar Award, the Doris Duke Clinical Scientist Award, and the Kimmel Scholar Award.

Contents

**Preface IX** 

**Part 1 DNA Damaging Agents 1** 

Chapter 1 **The DNA-Damage Response to** 

Cristina Girardi and Lucia Celotti

Simona Catalani and Pietro Apostoli

Chapter 2 **Interactions by Carcinogenic Metal** 

**Ionizing Radiation in Human Lymphocytes 3**  Maddalena Mognato, Mauro Grifalconi, Sabrina Canova,

**Compounds with DNA Repair Processes 29** 

Chapter 3 **Effect of Oxidative Stress on DNA Repairing Genes 49** 

Chapter 4 **UV Damaged DNA Repair & Tolerance in Plants 73**  Ashwin L. Ganpudi and Dana F. Schroeder

Chapter 5 **DNA Helix Destabilization by Alkylating Agents: From Covalent Bonding to DNA Repair 97** 

Gaëlle Lenglet, Sabine Depauw,

Balam Muñoz and Arnulfo Albores

Chapter 8 **Involvement of Non-Homologous End-Joining** 

Yasuyoshi Oka and Shunichi Yamashita

Chapter 7 **DNA Repair: Lessons from the Evolution of Ionizing-**

**in Radiation-Induced Genomic Instability 157**  Keiji Suzuki, Motohiro Yamauchi, Masatoshi Suzuki,

Chapter 6 **DNA Damage Caused by Polycyclic** 

Haïtham Sghaier

Bedia Cakmakoglu, Zeynep Birsu Cincin and Makbule Aydin

Denise Mendy-Belaiche and Marie-Hélène David-Cordonnier

**Aromatic Hydrocarbons: Mechanisms and Markers 125** 

**Radiation-Resistant Prokaryotes – Fact and Theory 145** 
