**8.4 BRMS1**

Breast cancer metastasis-suppressor 1 (BRMS1) decreases metastatic potential of tumor cells, although tumorigenicity do not affected. The mechanism underlying BRMS1 tumor suppression is not yet known, but some data suggest that this role may be mediated by enhanced immune recognition, altered transport, and/or secretion of metastasis-associated proteins (53).
