**8. Conclusion**

The search for novel therapeutic targets and the development of inhibitors of cancer metastasis is an ongoing challenge. Herein, we used a detergent assisted refolding chromatography process to convert globular HSA into fibrillar F-HSA. Unlike globular HSA, this novel F-HSA caused cell death, reversed EMT, and suppressed breast cancer cell migration through targeting 1 integrin signaling pathway. These important findings may be useful for the development of better therapeutics for the intervention of breast cancer metastasis.
