**Meet the editors**

Dr. Mehmet Gunduz graduated from the Faculty of Medicine of Hacettepe University in Ankara, Turkey in 1990. From 1995 until 2009 he studied and worked in Japan, both at Wakayama Medical University and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences at various academic levels (from PhD candidate to Assistant Professor). During this

period, he led a discovery and identification of roles of several cancer-related genes such as ING1 and 3. He has also been a visiting scientist in MD Anderson Cancer Center University of Texas, Houston, USA. Since March 2011, he is holding the position of a Professor at the Departments of Otolaryngology and Medical Genetics in School of Medicine Fatih University in Ankara. He has over 150 publications in internationally indexed journals, and over 160 presentations at various levels in national and international meetings. He also served as a reviewer for a number of journals.

Dr. Esra Gunduz is Associate Professor of Medical Genetics at Fatih University Medical School, Ankara, Turkey. She completed her PhD program in 2005 at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan. She was awarded by the Japan Society for the Promotion of Science (JSPS) as a post-doctoral fellow in 2006. In 2009

she was appointed as Assistant Professor at Fatih University, and in 2010 she was promoted to Associate Professor at the same faculty. Her research focuses mainly on tumor suppressor genes. In her lab she leads various ongoing projects for her research teams. She contributed to the literature with forty articles in peer reviewed journals and over sixty presentations both in national and international meetings.

Contents

**Preface IX** 

Judith C. Keen

Chapter 2 *In Vitro* **Breast Cancer Models as** 

**Part 1 Breast Cancer Cell Lines, Tumor Classification,** 

**Useful Tools in Therapeutics? 21**  Emilie Bana and Denyse Bagrel

Chapter 3 **Insulin-Like-Growth Factor-Binding-Protein 7: An Antagonist to Breast Cancer 39** 

Chapter 4 **Breast Cancer: Classification Based on Molecular** 

Siddik Sarkar and Mahitosh Mandal

Chapter 5 **Remarks in Successful Cellular Investigations for Fighting Breast Cancer Using Novel** 

Chapter 6 **Breast Cancer from Molecular Point of View: Pathogenesis and Biomarkers 103**  Seyed Nasser Ostad and Maliheh Parsa

**Part 2 Breast Cancer and Microenvironment 127** 

Chapter 7 **Novel Insights Into the Role of Inflammation** 

J. Valdivia-Silva, J. Franco-Barraza, E. Cukierman and E.A. García-Zepeda

**Synthetic Compounds 85** 

Chapter 1 **Breast Cancer Cell Line Development and Authentication 3** 

Tania Benatar, Yutaka Amemiya, Wenyi Yang and Arun Seth

**Etiology Influencing Prognosis and Prediction 69** 

Farshad H. Shirazi, Afshin Zarghi, Farzad Kobarfard, Rezvan Zendehdel, Maryam Nakhjavani, Sara Arfaiee, Tannaz Zebardast, Shohreh Mohebi, Nassim Anjidani,

**in Promoting Breast Cancer Development 129** 

Azadeh Ashtarinezhad and Shahram Shoeibi

*In Vitro* **Cancer Models 1** 
