**1. Introduction**

208 Breast Cancer – Focusing Tumor Microenvironment, Stem Cells and Metastasis

Vlodavsky, I., Elkin, M., Abboud-Jarrous, G., Levi-Adam, F., Fuks, L., Shafat, I. & Ilan, N.

Walsh, M.D., Luckie, S.M., Cummings, M.C., Antalis, T.M. & McGuckin, M.A. (1999).

Walter, M., Liang, S., Ghosh, S., Hornsby, P.J. & Li, R. (2009). Interleukin 6 secreted from

Wesseling, J., van der Valk, S.W. & Hilkens, J. (1996). A mechanism for inhibition of E-

Wiedemann, D., Schneeberger, S., Friedl, P., Zacharowski, K., Wick, N., Boesch, F.,

Yakovlev, S., Gorlatov, S., Ingham, K. & Medved, L. (2003). Interaction of fibrin(ogen) with

Yakovlev, S. & Medved, L. (2009). Interaction of fibrin(ogen) with the endothelial cell

Yakovlev, S., Zhang, L., Ugarova, T. & Medved, L. (2005). Interaction of fibrin(ogen) with

Yamaguchi, T., Yamamoto, Y., Yokota, S., Nakagawa, M., Ito, M. & Ogura, T. (1998).

Yang, E., Hu, X.F. & Xing, P.X. (2007). Advances of MUC1 as a target for breast cancer

Yigit, E., Gonullu, G., Yucel, I., Turgut, M., Erdem, D. & Cakar, B. (2008). Relation between

Yuan, Z., Wong, S., Borrelli, A. & Chung, M.A. (2007). Down-regulation of MUC1 in cancer

Zacharowski, K., Zacharowski, P., Reingruber, S. & Petzelbauer, P. (2006). Fibrin(ogen) and

Zacharowski, K., Zacharowski, P.A., Friedl, P., Mastan, P., Koch, A., Boehm, O., Rother, R.P.,

Zhang, G.J. & Adachi, I. (1999). Serum interleukin-6 levels correlate to tumor progression and prognosis in metastatic breast carcinoma. *Anticancer Res* 19(2B):1427-32.

*Connect Tissue Res* 49(3):207-10.

*Oncogene* 28(30):2745-55.

*Biochemistry* 42(25):7709-16.

*Intern Med* 19(8):602-7.

*Med* 84(6):469-77.

and in vitro. *Breast Cancer Res Treat* 58(3):255-66.

episialin/MUC1. *Mol Biol Cell* 7(4):565-77.

gamma-module. *Biochemistry* 44(2):617-26.

cancer patients. *Jpn J Clin Oncol* 28(12):740-4.

*Biochem Biophys Res Commun* 362(3):740-6.

ischemia-reperfusion. *Shock* 27(6):631-7.

immunotherapy. *Histol Histopathol* 22(8):905-22.

cardiac transplant model. *Transplantation* 89(7):824-9.

extracellular VE-cadherin domain. *Biochemistry* 48(23):5171-9.

(2008). Heparanase: one molecule with multiple functions in cancer progression.

Heterogeneity of MUC1 expression by human breast carcinoma cell lines in vivo

adipose stromal cells promotes migration and invasion of breast cancer cells.

cadherin-mediated cell-cell adhesion by the membrane-associated mucin

Margreiter, R., Laufer, G., Petzelbauer, P. & Semsroth, S. (2010). The fibrin-derived peptide Bbeta(15-42) significantly attenuates ischemia-reperfusion injury in a

heparin: further characterization and localization of the heparin-binding site.

receptor VE-cadherin: Localization of the fibrin-binding site within the third

leukocyte receptor alpha M beta 2 (Mac-1): further characterization and identification of a novel binding region within the central domain of the fibrinogen

Involvement of interleukin-6 in the elevation of plasma fibrinogen levels in lung

hemostatic parameters and prognostic/predictive factors in breast cancer. *Eur J* 

cells inhibits cell migration by promoting E-cadherin/catenin complex formation.

its fragments in the pathophysiology and treatment of myocardial infarction. *J Mol* 

Reingruber, S., Henning, R., Emeis, J.J. & Petzelbauer, P. (2007). The effects of the fibrin-derived peptide Bβ15-42 in acute and chronic rodent models of myocardial
