**3. Conclusion**

In summary, Histone modifications provide crucial regulatory functions in the process of gene transcription, and they play very important roles in the proliferation, metastasis, chemotherapy and other aspects of breast cancer, as well as many other human cancers. The reversibility of histone modification makes it could be regarded as one valuable target for the development of novel anticancer strategies. The understanding of all these epigenetics changes and their contribution to breast cancer might take great progress in the eld of diagnosis, prognosis and therapy of breast cancer.
