**Preface XIII**

	- **Part 2 Breast Cancer and Microenvironment 127**
	- J. Valdivia-Silva, J. Franco-Barraza,
	- E. Cukierman and E.A. García-Zepeda

Contents VII

Chapter 19 **p130Cas and p140Cap as the Bad and Good Guys in Breast Cancer Cell Progression to an** 

E. Turco, S. Cabodi and P. Defilippi

Chapter 20 **Fibrillar Human Serum Albumin Suppresses** 

Shao-Wen Hung, Chiao-Li Chu, Yu-Ching Chang and Shu-Mei Liang

and Behjatolah Monzavi-Karbassi

Chapter 23 **Junctional Adhesion Molecules (JAMs) -** 

P. Di Stefano, M. del P. Camacho Leal, B. Bisaro, G. Tornillo, D. Repetto, A. Pincini, N. Sharma, S. Grasso,

**Breast Cancer Cell Growth and Metastasis 423**

**Their Core Proteins in Breast Cancer Metastasis 435**

Chapter 21 **On the Role of Cell Surface Chondroitin Sulfates and** 

Chapter 22 **Endocrine Resistance and Epithelial Mesenchymal Transition in Breast Cancer 451** Sanaa Al Saleh and Yunus A. Luqmani

**New Players in Breast Cancer? 487**

Chapter 24 **Breast Cancer Metastasis: Advances Through the** 

**Role of the Microenvironment 531**  Jenna E. Fong and Svetlana V. Komarova

Anthony Magliocco and Cay Egan

Chapter 25 **Breast Cancer Metastases to Bone:**

Chapter 26 **Rho GTPases and Breast Cancer 559**  Xuejing Zhang and Daotai Nie

Gozie Offiah, Kieran Brennan and Ann M. Hopkins

**Use of In Vitro Co-Culture Model Systems 511** 

Ann Marie Kieber-Emmons, Fariba Jousheghany

**Invasive Phenotype 403**

	- **Part 3 Breast Cancer Stem Cells 235**
	- **Part 4 Breast Cancer Gene Regulation 289**
	- **Part 5 Breast Cancer Cell Interaction, Invasion and Metastasis 359**

Chapter 19 **p130Cas and p140Cap as the Bad and Good Guys in Breast Cancer Cell Progression to an Invasive Phenotype 403**  P. Di Stefano, M. del P. Camacho Leal, B. Bisaro, G. Tornillo, D. Repetto, A. Pincini, N. Sharma, S. Grasso, E. Turco, S. Cabodi and P. Defilippi

VI Contents

Chapter 8 **Interleukin-6 in the Breast Tumor Microenvironment 165**

**Migration During Breast Cancer Metastasis 183**

Chapter 10 **Hyaluronan Associated Inflammation and Microenvironment** 

Caitlin Ward, Catalina Vasquez, Cornelia Tolg,

Chapter 11 **The Microenvironment of Breast Cancer Stem Cells 237**

Jürgen Dittmer, Ilka Oerlecke and Benjamin Leyh

Patrick G. Telmer and Eva Turley

Deepak Kanojia and Hexin Chen

Chapter 12 **Involvement of Mesenchymal Stem Cells in Breast Cancer Progression 247** 

**Part 4 Breast Cancer Gene Regulation 289** 

Chapter 15 **Histone Modification and Breast Cancer 321** 

Chapter 16 **MCF-7 Breast Cancer Cell Line, a Model for the Study of the Association Between Inflammation** 

Chapter 17 **Interaction of Alkylphospholipid Formulations with Breast Cancer Cells in the Context of Anticancer Drug Development 361** Tilen Koklic, Rok Podlipec, Janez Mravljak,

Marjeta Šentjurc and Reiner Zeisig

Chapter 18 **The Mesenchymal-Like Phenotype of the MDA-MB-231 Cell Line 385**

Khoo Boon Yin

Chapter 14 **Epigenetics and Breast Cancer 291** Majed Saleh Alokail

**Part 3 Breast Cancer Stem Cells 235**

Chapter 13 **Breast Cancer Stem Cells 273**

Patricia J. Simpson-Haidaris, Brian J. Rybarczyk and Abha Sahni

**Remodelling Influences Breast Cancer Progression 209** 

Fengyan Yu, Qiang Liu, Yujie Liu, Jieqiong Liu and Erwei Song

Xue-Gang Luo, Shu Guo, Yu Guo and Chun-Ling Zhang

**and ABCG2-Mediated Multi Drug Resistance 343** Fatemeh Kalalinia, Fatemeh Mosaffa and Javad Behravan

**Part 5 Breast Cancer Cell Interaction, Invasion and Metastasis 359**

Chapter 9 **The Role of Fibrin(ogen) in Transendothelial Cell** 

Nicholas J. Sullivan


Preface

researchers and educators in the field.

Cancer is the leading cause of death in most countries and continues to increase mainly because of the aging and growth of the world population as well as habitation of cancer-causing behaviors such as smoking and alcohol. Based on statistics of the GLOBOCAN 2008, about 12.7 million cancer cases and 7.6 million cancer deaths are estimated to have occurred in 2008 (Siegel et al. Ca Cancer J Clin 61:212-236, 2011). Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females, accounting for 23% of the total cancer cases and 14% of the cancer deaths. Thus cancer researches, especially breast cancer, are important to overcome both economical and physiological burden. The current book on breast cancer aims at providing information about recent clinical and basic researches in the field. The book includes chapters written by well-known authors, who are worldwide experts in their research areas. The current book covers topics such as characteristics of breast cancer cells, molecular tumor classification methods, in vitro cancer models, breast cancer and microenvironment, breast cancer stem cells, gene regulation in breast cancer, and mechanism of breast cancer cell interaction, invasion as well as metastasis. We hope that the book will serve as a good guide for the scientists,

> **Prof. Dr. Mehmet Gunduz Assoc. Prof. Dr. Esra Gunduz** Fatih University Medical School

> > Turkey
