**1.1 Defining sepsis**

Sepsis is the body's exaggerated response to an infection where a cascade of inflammation can potentially lead to multiorgan failure or death [1]. It is a condition that could impact patients across the healthcare continuum whether they are wellappearing neonates or geriatric patients with an abundance of medical problems. It is pervasive in its ability to affect nearly every organ system requiring comprehensive multi-specialty care. Healthcare providers have been grappling with treatment of sepsis for as long as medicine has been practiced. As a field, we have made great strides in the ability to identify and treat sepsis, but it still kills nearly 270,000

people annually in the United States. We have a variety of therapeutics to treat the source of infection but one area that remains elusive is the ability to predict sepsis prior to onset.
