**3.1 Key variables for the CS-DI**

In our model, the CS-DI, our patient cohort was extracted based on meeting the following inclusion criteria:

1.Inpatient Hospital Admission


A41.2 Sepsis due to unspecified staphylococcus.

A41.51 Sepsis due to *Escherichia coli* [*E. coli*].

A41.52 Sepsis due to Pseudomonas.

A41.59 Other Gram-negative sepsis.

A41.81 Sepsis due to Enterococcus.

A41.9 Sepsis, unspecified organism.

R65.10 SIRS of noninfectious origin w/o acute organ dysfunction.

R65.11 SIRS of non-infectious origin w acute organ dysfunction.

R65.20 Severe sepsis without septic shock.

R65.21 Severe sepsis with septic shock.

Based on these inclusion criteria, our annual patient cohort ranged from approximately from 4462 to 5729 patients per year. The following variables were extracted from our database to be used as features in the CS-DI:
