**Acknowledgements**

This work was supported by the National Natural Science Foundation of China (52122501), the Major Scientific and Technological Innovation Project of Shandong Province (2019JZZY021002), Qingdao People's Life Science and Technology Project (18-6-1-64-nsh), and the Taishan Scholar Program of Shandong Province (tsqn20161077). The sponsors played a role in the design and conduct of the study and collection of the data.
