**1.2 Bacterial biofilm eradication mechanisms**

Biofilms are difficult to eradicate even with extended treatment and important attention is given to less conventional treatments, especially those that employ macromolecular species [12, 13]. Because of this failure of conventional therapeutics biofilms require other strategies and mechanism for their elimination [14]. Many strategies are presently under investigation, aiming to effectively eradicate biofilmrelated infections and several agents have been known to have anti-biofilm activity, including some natural products, synthetic compounds, enzymes, peptides, chelating agents, polyphenols, as well as some antibiotics [13, 14]. These biofilms have different mechanisms of action.


#### **Table 1.**

*Examples of representative bacterial pathogens that frequently form biofilms.*

*Bacterial Biofilm Eradication in Human Infections DOI: http://dx.doi.org/10.5772/intechopen.113341*
