**4. Anti-biofilm Furanone activity through anti-QS activity**

## **4.1 Furanones in general**

Furanones are a family of structurally related molecules characterized by the presence of a five-membered heterocyclic furan ring. Furanones are available in a number of natural sources like marine and terrestrial plants, strawberries, coffee and fungi, and can also be chemically synthesized. Both natural and synthetic furanones have been shown to effectively inhibit QS, but synthetic furanones offer the possibility of precise control over compound structure and, therefore, control of any potential off-target effects [20, 21].
