**Abstract**

Food poisoning is one of the main problems affecting public health. Bacterial adhesion on surfaces has been documented for decades, and it is known that biofilmforming bacteria are much more resistant than planktonic cells. Typically, nanosystems are studied regarding their antimicrobial activity (i.e., pathogenic bacteria such as *Campylobacter*, *Salmonella*, *Listeria monocytogenes*, *Escherichia coli* O157:H7, *Staphylococcus aureus*, *Clostridium perfringens*, *Bacillus cereus*, and *Yersinia enterocolitica*), but not for antibiofilm activity and their associated genes. Some studies established protein-ligand prediction concerning quorum sensing suppression, commonly called quorum quenching. This chapter focuses on nanosystems or functionalized nanomaterials that have demonstrated antibiofilm or quorum quenching activity and, thus, establishes perspectives in modeling specific nanosystems to eradicate biofilms produced by foodborne pathogens.

**Keywords:** nanosystems, quorum quenchers, food safety, biofilm formation inhibition, molecular docking
