**Abstract**

Climate is changing globally nowadays because of extensive crucial human activities. This state along with stark in weather measures ultimately affecting the development and growth of crops due to various kinds of stressful field condition at the same time including biotic and abiotic stresses. Thus, various biotic factors including pathogens, weeds and pests and abiotic factors including temperature, humidity and drought etc. are involved in reduction of cotton yield due to which cotton production significantly reduced. Various biotic factors have direct effect on the cotton production and caused significant reduction in cotton crop yield estimated up to 10 to 30%, while as abiotic factors are even worse than biotic stresses and could cause 50% reduction. So, effective agronomic practices, optimal climate and integrated pest management leads to fruitful crop production to cover this yield gap. This chapter will be broadly useful to design projects aimed with inter and intradisciplinary collaboration for sustainable cotton production.

**Keywords:** cotton pathogens and pests, climate change, biotic and abiotic factors, combined effect, sustainable production, IPM
