**9. Other applications**

Carvacrol and thymol have demonstrated cytotoxic effects against various cancer cell lines, including breast, colon, and prostate cancer cells. This activity has been explained by the management of inflammatory conditions of OEO. The OEO metabolites induce apoptosis (programmed cell death), inhibit tumor growth, and show promise as adjuvants in cancer treatment. Furthermore, it has been suggested that OEO oil metabolites, particularly carvacrol, may have antidiabetic effects. They help regulate blood sugar levels, improve insulin sensitivity, and inhibit certain enzymes involved in carbohydrate metabolism [10]. However, further research is needed to establish their clinical significance in diabetes management.

Other applications in ethnopharmacological studies have been found to suggest *L. origanoides* for disorders of the genitourinary system used specially by quilombola women from Oriximiná. These applications have also been found to demonstrate an antispasmodic action, analgesic and antimicrobial uses of other species of *Lippia* genus rich in thymol and carvacrol [48]. In addition, oregano has been found to modulate innate immunity parameters in *Lumbricus terrestris* [21]. It has also been shown to improve immune response, activity of digestive enzymes, and intestinal microbiota of the koi carp, *Cyprinus carpio* [49].
