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## IntechOpen Book Series Biochemistry

Volume 48

### Aims and Scope of the Series

Biochemistry, the study of chemical transformations occurring within living organisms, impacts all of the life sciences, from molecular crystallography and genetics, to ecology, medicine and population biology. Biochemistry studies macromolecules - proteins, nucleic acids, carbohydrates and lipids –their building blocks, structures, functions and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins and hormones, which play roles in the life process. Biochemical experimentation, besides coopting the methods of classical chemistry, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the 'big data' omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying and examining individual components of a biological system; in exemplary words of Efraim Racker, (1913 –1991) "Don't waste clean thinking on dirty enzymes." Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe fully a particular biological system. The 'big data' metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the proteins comprising e.g., serum; metagenomics can identify all the genes in a complex environment e.g., the bovine rumen.

This Biochemistry Series will address both the current research on biomolecules, and the emerging trends with great promise.

## Meet the Series Editor

Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg's research is focused

on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.

## Meet the Volume Editor

Professor Leisheng Zhang is a cell biologist and the leader of a research team devoted to tissue engineering and regenerative medicine. In 2012, he obtained a bachelor's degree in veterinary medicine (a BVetMed degree) from Jilin University, China. In 2018, he obtained a Ph.D. in Cellular Biology from the Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) and Tsinghua University, China. In 2021 and

2023, Dr. Zhang completed post-doctoral research at the School of Medicine, Nankai University, China and the Chinese Academy of Sciences (CAS), respectively. In 2024, Dr. Zhang was the central laboratory director and an academic leader at The Fourth People's Hospital of Jinan and the teaching hospital of Shandong First Medical University. He was also a distinguished professor at Gansu Provincial Hospital, and a principal investigator in Shandong Public Health Clinical Center, Shandong University. For decades, Dr. Zhang has undertaken projects funded by the National Natural Science Foundation of China. He has published more than eighty articles and twenty books and has thirty patents to his credit.

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