**2.4 Gene ontology and KEGG pathway analysis of cancer drug targets**

Web-based gene set analysis toolkit (WebGestalt, http://www.webgestalt.org/ option.php) is a web-based tool for functional interpretation of gene sets. It can be used to identify enriched biological themes, functional categories, and pathways among the input gene set, compare the input gene set with reference sets [75]. We employed WebGestalt to perform GO [76] and KEGG pathway analysis [77] for drug target genes in cancer. Gene ontology analysis was carried out to understand the biological process and molecular function of the drug target genes. Additionally, KEGG pathway analysis was also performed on these genes. Results with a false discovery rate (FDR) < 0.05 were considered significant.
