**6. Future perspective**

The potential of solanine and chaconine as cancer treatment requires further clinical validation. Studies should be designed to evaluate the efficacy, safety, and pharmacokinetics of these glycoalkaloids in different types of cancers. Furthermore, as predicted and validated, glycosylation enhances the solubility of this family of compounds, opening the gate to a new era of nano-based therapies of glycoalkaloids based on this fact. Mechanistic studies are needed to further validate the interaction between the compounds and screened targets to establish the connection between drugs and their anticancer potential. SAR analysis of the structures infers that structural modifications of these compounds might enhance their pharmacokinetic properties, alter their physicochemical properties, reduce their toxicity to normal cells, and potentiate their toxicity against cancer cells.
