**2.1 Endotoxin toxicity**

Endotoxins enter into living organisms via blood cells and causes several diseases including respiratory syndrome, fever, hypertension, intravascular coagulation and other related shock. It also causes sepsis, however the main mechanism of endotoxin mediated sepsis is still not clear. It depends on some of the genetic factor, the infection

**Figure 1.** *Structure of endotoxin.*

*An Overview of Bacterial Toxigenesis and a Potential Biological Weapon in Warfare DOI: http://dx.doi.org/10.5772/intechopen.114054*

site, virulence factor, and the host response. The high concentration of enodotoxin involved in the activation of toll like receptors (TLR4), caspases and RAGE, that causes septic shock and ultimately death while low concentration causes inflammation and other less severe symptoms like rashes, fever etc. In the septic patient the endotoxin concentration (2.5–12 EU/mL) were detected in plasma. Similarly, meningococcal patient admitted in hosptital for septic shock having endotoxin 5 EU/mL level in their blood [7].
