**2.3 Cancer-related genes collection**

This study collected cancer-related genes from Genecards database [73] (https:// www.genecards.org/) and disease and gene network database [74] (DisGeNet: https://www.disgenet.org/). In DisGeNet, genes with gene-disease association (GDA) score equal or greater than 0.1 were obtained. In GeneCards genes with relevance score greater than 10 were obtained by using. The obtained genes from both databases were then combined, and duplicate genes were eliminated. The final dataset of cancer-related genes was used for further analysis.
