**Acknowledgements**

The authors would like to acknowledge the great help and support of STDF for the continuous support and financial funds for STDF grants within the framework of the German Egyptian Research Fund (GERF), Project ID: 33601, "A novel innovative Approach for the Optimization of Phytopharmaceuticals: Modulation of Medicinal plants Constituents by Elicitation", Principal Investigator: Farid A. Badria.
