**5. Conclusion**

Our study suggests that solanine and chaconine, two glycoalkaloids found in potatoes, may have potential anticancer effects through their interactions with cancerrelated genes. Despite the unpromising results of ADME testing, the glycosylation of solanine and chaconine increased their solubility and probability of inhibiting P-glycoprotein.

Our analysis identified 26 cancer targets common to both compounds, which were enriched in cancer-related pathways such as Pi3k-Akt1 and HIF-1 signaling pathways. Further analysis revealed that these genes were enriched in the regulation of cell death and programmed cell death. A protein-protein interaction network was constructed, and hub genes were identified as STAT3, TLR4, FGF2, IL2, NFKB1, AR, CHUK, TRIM24, NOS3, and KDM1A. Survival analysis indicated that these genes have prognostic value in one or more types of cancer.

*Perspective Chapter: Integrated Network Pharmacology and Multiomics Approach to Elucidate… DOI: http://dx.doi.org/10.5772/intechopen.112789*

Overall, our findings provide valuable insights into the potential mechanisms underlying the anticancer effects of solanine and chaconine and highlight the potential therapeutic applications of these glycoalkaloids in cancer treatment. The identification of hub genes with prognostic value suggests that they may serve as potential targets or biomarkers for diagnosis, prognosis, or treatment response in cancer. Further, research is needed to validate these findings and explore the full potential of solanine and chaconine in cancer therapy.
