**4. Donor-recipient matching and preventive way for hyperacute rejection or early phase antibody-mediated rejection**

The recommendation for donor-recipient match at the time of transplant is a virtual crossmatch, which compares recipient anti-HLA antibody with donor HLA antigens (Class I, Level of Evidence C) [2].

Prospective or virtual crossmatch should be performed in recipient with PRA >10% (Class I, Level of Evidence C) [2].

Biopsies and circulating antibodies should be done routinely after transplantation. *De novo* donor-specific antibodies may be associated with poor outcome.
