**Abstract**

The unique clinical and surgical experience with cardiac valve allografts is presented in the study. Cutting-edge approach with regard to clinical course of the disease, particular diagnostic findings, patient's preference, and allograft accessibility is highlighted in case series. State-of-the-art techniques, initial and mid-term results are summarized with a specific focus on allograft tissue application in cardiovascular surgery. Four patients underwent surgery during the period between February 2020 and February 2023 with inferior vena cava tumor involvement, destructive double valve endocarditis, rheumatic aortic and mitral insufficiency, and severe tricuspid regurgitation in patients with large ostium secundum and atrial fibrillation. All patients demonstrated an uneventful postoperative course.

**Keywords:** allograft, inferior vena cava, endocarditis, rheumatic heart disease, tricuspid replacement
