a. Systemic steroids

Due to their availability and quick therapeutic effect, are used as first-line therapy in acute inflammatory diseases. Oral prednisone treatment is usually started with a dose of 1 mg/kg/day (maximum 100 mg/day) and then gradually tapered depending on clinical response [1]. For severe PUK, which threatens vision, intravenous pulses of methylprednisolone (1 g/day for 3 days) are used, followed by a switch to orally administered prednisone and a gradual reduction in dose [48]. Still, the side effects of chronic steroid administration should be kept in mind: glucocorticoid effect, electrolyte disturbances, hypertension, and hyperglycemia. Adjuvant use of H2-blockers to prevent steroid-related gastric ulcers is advisable as well as calcium supplementation to prevent bone density reduction [66].
