**7.1 Surgical techniques**

	- Cyanoacrylate glue (butyl monomers) has optimal tectonic strength and rapid polymerization making it widely used for the closure of corneal perforations under 3 mm in PUK of autoimmune etiology [91]. Additionally, it acts as a barrier preventing the inflow of inflammatory cells from the conjunctiva [92]. This adhesive remains for at least a month on the corneal surface followed by spontaneous displacement typically due to epithelial healing that occurs beneath [91]. However, since it is not biodegradable, it has the potential to produce foreign body sensation, papillary conjunctivitis (hence the need for a bandage lens

application), corneal neovascularization, infection, and tissue necrosis. If the glue enters the anterior chamber, it can cause corneal adhesion to the iris, pupillary block, secondary glaucoma, granulomatous reaction, and cataract [93, 94].

