**6.2 Systemic treatment**

Management of PUK associated with autoimmune diseases requires close cooperation between an ophthalmologist and an internist/rheumatologist. Systemic therapy should be directed to both reduce ophthalmological as well as the life-threatening complications of underlying systemic disease [4–6]. The choice of treatment depends on multiple factors including etiology, clinical presentation, severity of disease, systemic co-morbidities, preferred route of drug administration, side effects of medications as well as the patient's general condition including the hematological, liver, and kidney profile [5].
