**8. Conclusions**

Hyperammonemia is a serious condition and must be considered in all patients with unexplained alterations in neurological status. Hyperammonemia in adult patients is usually caused by liver diseases, and non-hepatic causes are uncommon. Treatment of non-hepatic causes of hyperammonemia includes general supportive measures, as well as investigating and treating the underlying cause. Data about the role of RRT in the management of adult patients with hyperammonemia are limited. In such cases, many factors must be taken into consideration, including the clinical condition of the patient, severity of hyperammonemia, underlying cause, and response to supportive therapy. If RRT is considered, the choice of modality and the dialysis prescription depend on the patient's condition and available resources. Intermittent hemodialysis provides the highest and the most rapid degree of ammonia clearance, followed by CRRT, then PD.
