**Abstract**

Hemodialysis is the lifesaving treatment for End-Stage Renal Disease (ESRD) patients; however, the treatment's nature impacts the patient's quality of life and mental health. Focusing on the mental health of patients receiving hemodialysis, the chapter draws attention to the psychological interventions that can improve patient's quality of life. The mental health of ESRD patients receiving hemodialysis can be improved with cognitive-behavioral therapy, psychoeducation, relaxation techniques, peer support groups, spiritual therapy, and technology-based psychological interventions.

**Keywords:** hemodialysis, mental health, quality of life, psychological interventions, end-stage renal disease
