**Abstract**

In hemodialysis (HD) patients, depression is linked to morbidity, mortality, a worse quality of life, a shorter life expectancy, and even suicidal thoughts. Intradialytic exercise is regarded as a crucial part of the clinical care management of HD patients because it enhances the effectiveness of HD, lowers systemic inflammation, increases exercise tolerance, lowers depressive symptoms, and improves quality of life.

**Keywords:** intradialytic exercise, depression, hemodialysis, quality of life, hemodialysis effectiveness, exercise tolerance, physical activity, Hamilton depression rating scale
