**8. Danazol**

Danazol was synthesized in 1963 and was introduced for medical use in 1971 [13–15]. The mechanism of action of danazol is complex. It acts as a weak androgen, a functional antiestrogen, an anabolic steroid, a weak antigonadotropin, a weak progestogen, and a weak steroidogenesis inhibitor [16–23].

Danazol may be prescribed in cases for endometriosis, fibrocystic breast disease, hereditary angioedema, and other conditions [16–23].

Danazol has been shown to be effective in controlling symptomatic primary menorrhagia [24]. It has to be noted that the use of danazol may be associated with some unacceptable masculinizing side effects such as acne, excessive hair growth, breast atrophy, hot flashes, voice deepening, mood changes, and other long-term side effects [17, 25].
