**3.10 PON2 and future perspectives**

The identification and initial characterization of PON2 in brain tissue suggest that this enzyme may play a relevant role in determining susceptibility to oxidative stress and neuroinflammation, and that its positive modulation may represent a novel strategy for neuroprotection. Attempts to elevate PON2 levels could be neuroprotective. For tumor cells, PON2 overexpression probably provides resistance of these cells to apoptosis and that a useful therapeutic strategy would be one causing a decrease of PON2 [71].
