*2.3.2 Chlamydial HtrA*

Chlamydial HtrA (cHtrA) is a hexamer with proteolytic activities. It is a periplasmic protein. It acts as a protease that acts on the endoplasmic reticulum of host cells and cleaves the transcription factors ATF6 and SREBP that are involved in cholesterol biosynthesis [14]. It also releases the sE-factor to activate stress response genes and is essential for the survival of the microorganism under high temperature [14]. HtrA is present in the chlamydial inclusion and is secreted in host cell cytosol, a unique property of chlamydial cells.
