**Abstract**

Lack of detection of chlamydia infection does not correspond to the high prevalence of its clinical manifestations. It is associated with a frequent asymptomatic course, the prevalence of persistent forms of infection and difficulties in their diagnosis. Unification of approaches to diagnosis and therapy of chlamydial infections without taking into account the topical diagnosis leads to insufficient therapy. It is difficult to find a balance between the need for long-term antibiotic therapy for chlamydial persistence and the dangers of its consequences. Difficulties in the treatment of chlamydia infection are also associated with socio-psychological factors: low efficiency and even inexpediency of etiotropic therapy of chlamydia in polygamous relationships, promiscuous behavior; poor synchronization of partner therapy, often treating only one partner in a couple; orientation of patients towards short-term "pill" therapy, which is not sufficiently effective for chronic persistent chlamydia with significant morphological changes in the genitals; low compliance of male partners to therapy in a couple "by contact" in the absence of clinically apparent manifestations; peculiarities of public consciousness regarding chlamydia infection. As a result, therapy often only stops exacerbations of inflammation and does not eliminate the infection completely.

**Keywords:** chlamydiosis, persistent form of chlamydia infection, biopsychosocial approach to chlamydia, management of patients, socio-psychological problems
