**8. Prevention**

Early recognition of the disease is fundamental through the signs and symptoms described, in order to perform a precocious immunomodulatory treatment that allows the control of the disease and better outcomes. Clinical alert should be maintained as long as SARS-CoV-2 is circulating within the population. While clinics maintain the search for MIS-C in febrile children, it is necessary at the same time preventing waves of new viral variants and the emergence of high rates of MIS-C which until now remains low. It seems that the only way to prevent the disease is to maintain vaccination of the entire population. SARS-CoV-2 is a virus that is here to stay, but can be controlled by vaccination. The massive inoculation of the population led the virus to mutate into variants that are apparently less susceptible to producing severe inflammatory phenomena in children, as seen in the omicron wave. If the world population lowers its vaccination rates, it is likely that the virus will continue to mutate, giving the possibility of new variants that could have the potential to cause higher MIS-C rates again. It is possible that areas with less economic development and therefore less access to vaccines keep low vaccination rates. In those places, the possibility of the appearance of new variants could be high. Efforts should also be maintained for the implementation of the vaccine at all pediatric ages, given the actual change in the epidemiology of MIS-C at younger ages without access to vaccination.
