**3. Pathophysiology**

MIS-C is presented late in relation to the peak of SARS-CoV-2 cases, which is why it is suggested from the outset that it would be an immune-mediated post-infectious disease. The presence of antibodies to SARS-CoV-2 often without a positive PCR made this theory more accurate. Serology is positive even up to 90% of cases; however, the molecular detection of the virus by PCR varies between 20 and 40%. Until now, the exact pathophysiology is unknown, but there are theories that try to explain how SARS-CoV-2 causes such a dysregulated response in children [25].
