**1. Introduction**

As with any rapidly developing technology, Edge Computation (EC) seems to offer significant benefits to humans and society but also will likely have unanticipated consequences, some of which may harm or immiserate humans and even affect environmental functionality. Within this context, this chapter will attempt to define and describe EC from a variety of perspectives including germane theoretical frameworks and issues, methodological principles, and operational/technological applications. The major substantive issues covered will include defining EC, EC and global health, epidemiological aspects of EC, EC from an ecological perspective, EC and modern evolutionary neurobiology, EC and artificial intelligence, integrated sensor/software/ hardware/network development, heart rate variability(HRV), and advanced technology for psychobiological assessment and intervention, including nanomaterials, implantable technology, and bioelectric power generation. The chapter will conclude with an identification of high-impact, high-risk applications and policy directions to address such applications.
