**Abstract**

Edge computation (EC) will be explored from the viewpoint of complex systems. An evolutionary and ecological context will be described in detail, including the subjects of epigenetics, self-domestication, attachment theory, scientific cosmology, deep learning, and other artificial intelligence issues and the role of wireless data acquisition analysis and feedback. A technical exemplar will be described and examples of potential integration with various systems such as public health and epidemiology, clinical medicine, operations, and fitness will be proposed. Also, various system vulnerabilities and failures will be discussed and policy implications in the global and clinical health and wellness domains will be identified.

**Keywords:** edge computation (EC), transdemic, digital epidemiology, internet of healthy things, global health, hardware/software/networked systems, wearable devices, heart rate variability (HRV), complex adaptive systems, i4P health, deep learning, consilience, digital twinning, psychological science, regenerative medicine
