**1. Introduction**

Liver diseases represent the tenth leading cause of death in the world and one of the leading causes of disability and years of life lost. Regardless of the etiology of liver disease, only 10% of those who require an organ get a transplant.

Acute liver failure and acute-on-chronic liver failure are serious pathologies, which despite the treatment of the cause and the associated complications, many of them require organ support through an artificial or biological system until the recovery of the liver is achieved. Liver support systems act as a bridge to liver transplantation [1].
