**Abstract**

Several psychosocial stressors have an impact on patients with end-stage kidney disease (ESKD). The disease and its treatment modalities impose several lifestyle changes. These include the impact of disease and treatment, dietary and fluid restrictions, functional limitations and sexual dysfunction, and future uncertainty and fear of death. Furthermore, family and social issues such as changes in family roles and changes in duties and responsibilities may add to psychosocial stressors among people on dialysis. Commonly associated psychosocial issues include depression, anxiety, delirium, withdrawal, and decreased quality of life. The prevalence and severity of each psychological issue vary, and there are several tools available to detect these issues. This chapter will focus on the most common psychosocial stressors among people with hemodialysis.

**Keywords:** anxiety, depression, delirium, hemodialysis, psychosocial issue, stressors, withdrawal
