**2. Conclusion**

Co-crystals enable a wide range of APIs to be used in pharmaceutical therapy. Some of the most appealing properties of co-crystallized APIs are increased solubility and chemical and physical stability. Because of their patentability, they are also appealing from an economic and legal standpoint. Several difficulties arise when attempting to create co-crystals. The prediction of the crystal structure of larger molecules is time consuming and difficult. The predicted structure will not always match the experimental result. Even though methods such as liquid-assisted grinding are very efficient in the lab, they are economically unfavourable in large-scale synthesis. Overall, because of improved drug delivery performance, stability and an important intellectual property status, co-crystals are expected to play an important role in future drug development.

*Modification of Physicochemical Properties of Active Pharmaceutical Ingredient… DOI: http://dx.doi.org/10.5772/intechopen.110129*
