**Figure 5.**

*Overall FbD strategy during drug delivery development.*

An interface like this provides guidance at every stage of the optimization cycle, including the design selection, factor screening, use of response surface designs, generation of the design matrix, plotting of 3-D response surfaces and 2-D contour

#### **Figure 6.**

*Selected computer software used during FbD implementation for product and process optimization.*


#### **Table 4.**

*List of computer Softwares available commercially for formulation by design (FbD) studies.*

plots as design spaces, optimum search, partial interpretation of the results, and validation of the methodology. **Table 4** outlines the specific computer software products that are commercially available for conducting FbD studies in an industrial setting. **Tables 5** and **6** illiterates examples of several approaches of FbD in the optimization of micro and nanoformulations and a comprehensive account of the independent variables and response variables used for various DDS.


### *Formulation by Design: An Overview DOI: http://dx.doi.org/10.5772/intechopen.109702*




#### **Table 5.**

*FbD optimization of various oral DDSs.*



#### **Table 6.**

*List of various independent variables and response variables chosen for various types of drug delivery system: [85].*
