**1.2 Physicochemical properties of co-crystals**

For the creation of APIs, co-crystals' physicochemical characteristics are crucial. Adjusting the physicochemical parameters of pharmaceutical co-crystals during drug development improves the stability and efficacy of the dosage form [34]. Numerous studies have been conducted on physicochemical characteristics such as solubility, dissolution, crystallinity, melting point, bioavailability, and stability. The following list summarizes some important physicochemical characteristics of pharmaceutical co-crystals [35].
