*3.5.3 Solution state stability studies*

Compared to solid-state reactions, liquid-state reactions are simpler to spot. The methodologies for detecting unidentified liquid incompatibilities are the same as for solid dosage forms. For suspensions and solutions formulations of bulk drugs, the investigations include listed conditions and they must be evaluated as per FDA stability guidelines, these conditions are higher nitrogen and oxygen environment, alkaline/acidic pH conditions, and the existence of chelating agents and stabilisers [64]. The results of stability studies can help guide stabilisation strategies, giving feedback to the chemistry team on how to modify labile groups to improve stability, assisting researchers in determining the compound's developability, and providing instructions on how to handle and store compounds [2].
