*1.4.4 Sonocrystallization method*

Organic co-crystals of finite size have been prepared using a sonochemical technique that has been developed. The creation of nanocrystals was the primary motivation behind this technique. The preparation of caffeine-maleic acid co-crystals began with the application of the ultrasound technique. The comparison of the sonochemical method and the solvent drop grinding method for producing caffeine, theophylline, and L-tartaric acid as API and co-formers has begun. The methods produced consistent results, demonstrating the importance of the sonocrystallization method [58].
