*1.5.5 Saturation solubility study*

In accordance with the procedure described by Higuchi and Connors, saturation solubility studies were carried out in triplicate in distilled water. To reach equilibrium, excess co-crystals were added to distilled water in a screw cap tube and shaken for 24 hours at room temperature in a rotary flask shaker. An appropriate aliquot was taken out, filtered through filter paper and then analysed with a spectrophotometer. Statistics were used to validate the data from saturation solubility studies [66, 67].
