*1.7.8 Taste masking*

Oral disintegrating tablets require fast disintegrating tablets with rapid dissolution. This strategy allows the use of tablets without the need for chewing or water intake, broadening the range of drug users to include geriatric, paediatric and travelling patients who do not have access to water. To improve the patient experience, readily disintegrating tablets require the use of taste masking agents. So far, the main approach has been to use sugar excipients. Co-crystallization could be a good strategy to improve dissolution rate using sugar-based coformers such as sucralose as coformer for preparing co-crystals with hydrochlorothiazide. The formed co-crystals provide the benefits of increased dissolution rate and taste masking of the product [127]. Another example, theophylline with the bitter taste was masked by formulating co-crystals with artificial sweeteners such as sodium glutamate, sodium saccharin and d-sorbitol. In 1:1 stoichiometric ratio *via* liquid-assisted grinding, the prepared co-crystal showed enhanced dissolution and sweet taste, which was detected by automated sweetness tasting machine [128].
