*3.5.4 Drug-excipients compatibility*

The medicine is in close contact with one or more excipients in the tablet dosage form; they could have an impact on the drug's stability. Therefore, understanding how drugs and excipients interact helps the formulator choose the best excipients. It's possible that this knowledge already exists for well-known drugs. The preformulation scientist must produce the necessary data for new medications or excipients. Binders, disintegrants, lubricants, and fillers are typically found in tablets [65]. A new drug's compatibility screening must take into account two or more excipients from each class. The preformulation scientist has a great deal of control over the medication-toexcipient ratio employed in these studies. The following conclusions are made from the drug-excipient compatibility studies [9].


Various sophisticated analytical techniques are used to detect drug-excipient compatibility are differential FT-IR spectroscopy, scanning calorimetry, fluorescence spectroscopy, differential thermal analysis, osmometry, diffuse reflectance spectroscopy, high-pressure liquid chromatography, radiolabelling [66].
