*1.4.5 Supercritical fluid atomization technique*

In the supercritical atomization process, CO2, a highly pressurized supercritical fluid, is used to combine the drug and coformers. By atomizing this solution with an atomizer, co-crystals are created. Co-crystals are prepared from solution using the supercritical antisolvent (SAS) method, which utilizes the antisolvent effect of supercritical fluid [59].
