**3. Conclusion**

The purpose of the present study was to investigate the effect of liquisolid technique in improving the dissolution profile of poorly aqueous soluble drugs mostly that belong to BCS Class II and Class IV. In this investigation, preformulation study i.e. saturation solubility was performed for drug in order to determine extent of its solubility in liquid vehicle, which forms basis for preparation of LSCs. However, solvent showing highest solubility for drug was selected as liquid vehicle for preparing liquid medication.

Further, liquisolid systems were formulated by the technique described and patented by Spireas et al. The liquisolid compacts were formulated with addition of carrier material (such as Avicel PH102) and coating material (such as Cab-O-Sil M5). During formulations the chemical compatibility between drug and excipients was checked and confirmed by FTIR study. The liquisolid preparations were initially characterized by precompression study for flowability and compressibility. The liquisolid powder systems were compressed to obtain liquisolid compacts which were further characterized for post compression tests such as hardness, content uniformity, disintegration and dissolution profiles. The stability studies were also conducted and the tablet properties like hardness, drug content, disintegration and dissolution profiles were compared for freshly prepared and aged tablets.

The drug loaded liquisolid formulations showed higher drug release profiles when compared with the conventional dosage forms for the same drug. Hence, this technique proved a substitute method to develop solid oral dosage forms for poorly watersoluble drugs. The method uses appropriate excipient ratios of biodegradable polymers which not only improve drug release but also sustain the drug release characteristics of the water-soluble drugs. Finally, it can be concluded that LS technology was effective for enhancing the dissolution behavior as well as the bioavailability of poorly water soluble or practically water insoluble drugs in presence of non-volatile solvents. Thus, liquisolid approach has potential application for formulation research in improvement of dissolution rate and hence proved to be a promising tool as well an alternative technique to enhance the dissolution profiles of very low aqueous soluble drugs.
