*2.8.11 In vitro drug release studies*

The *in vitro* drug release profiles for LSCs were determined by means of Rotating Paddle, USP Type II dissolution test apparatus (Electrolab, Mumbai, India). The dissolution was performed in 900 ml of selected dissolution media (SGF or SIF) with paddle speed of 50 rpm. Aliquots of 5 ml samples were collected at predefined time intervals. To maintain constant volume and sink conditions, the dissolution medium was replaced with 5 ml of fresh medium. These samples were analyzed using UV–VIS spectrophotometer at λmax of prepared drug. It is carried out in triplicates for each LSC batch and also compared with conventionally prepared directly compressed compacts containing an equivalent amount of drug for comparison [23].
