**1. Introduction**

Oral route is considered as the easiest, convenient and most frequently preferred route for the administration of pharmaceutical dosage forms. Drug solubility is the most important key factor to achieve desired concentration of drug in the systemic circulation and show its pharmaceutical action. The poor dissolution properties of non-aqueous soluble drugs possess major challenge for researchers in pharmaceutical field in the course of development of solid dosage forms intended for oral administration. The development of several methods during the past few years includes the application of pro-drug and drug derivatization processes, micronization,

co-precipitation, salt formation, solid dispersions, inclusion complex formation, lyophilization, micro-encapsulation, incorporation of drug solutions into soft gelatin capsules, self-emulsifying drug delivery systems, etc. In order to increase drug dissolution rate profiles, powder solutions are also designed that contain liquid medications in powdered form.

The rate of oral absorption is frequently regulated by the rate of dissolution in the GIT, in case of Biopharmaceutical Classification Class II drugs (low soluble and high permeable drugs). Therefore, solubility and dissolution rate characteristics of drugs are most important determinants of their oral bioavailability, together with permeation [1]. Hence, the notion of powdered solutions enables the creation of moderately flowing powders from liquid medications or drug solutions obtained by admixing drug solutions or liquid pharmaceuticals with selected powder excipient. Similar methods have been employed by certain researchers to improve the drug release patterns of numerous water-insoluble medicines.

The most recent, modern solubility enhancement approach known as liquisolid (LS) technique or "Powder Solution Technology" introduced by Spireas and Bolton, has been employed to develop rapid release solid dosage forms for water-insoluble or poorly water-soluble drugs [2]. The powdered forms of liquid medications produced via liquisolid process are thought to flow smoothly and also possess compressible nature. The liquid medication can be turned into dry (moistureless), non-sticky powder that can be easily flowable and compressible by simple mixing with chosen carriers, coating excipients [3]. In this method, the medication is dissolved in solvent followed by admixing with powder excipients and administered as solid dosage form. In this instance, the medication has been entirely molecularly distributed. As a result, insoluble or poorly water-soluble pharmaceuticals are anticipated to have improved dissolution rate characteristics and, consequently, higher bioavailability due to notably improved wetting capabilities and increased drug surface area accessible for dissolution.
