*2.1.1 Evaporative co-crystallization*

Co-crystallization is an ordinary evaporation technique for spawning co-crystals, archetypally implemented for procurement of single-crystal co-crystals appropriate for diffraction studies to explicate the co-crystal structure. The procedure embroils the cloud seeding and development of a co-crystal from a solution of equally API and co-crystal former in a solvent, with super-saturation as long as by elimination of the solvent from the solution through vaporization. Distinct co-crystals, or the main part of the crystal sample, are garnered prior the solution vanish to aridness to certify the retrieval of an unsoiled crystal(s). A low degree of desiccation is customarily sought to make sure the development of a large number of minor crystals is disproportionate to an insignificant number of larger crystals. As crystal structure identification is a necessary step in the discovery of novel co-crystal forms, evaporative co-crystallization is evident in the majority of the co-crystal related research papers, and there are countless examples of it in the literature [13].
