**4.2 Properties of APD-APIs co-crystals**

APD-APIs have poor physicochemical qualities, and their combination with coformers to produce co-crystals considerably improves a variety of attributes including thermal stability, solubility, and hygroscopicity [106]. The alteration of these APD-APIs affects therapeutic action while retaining pharmacological properties [97]. An overview of the key attributes of both APD-APIs and APD-APIs co-crystals is outlined in this section.
