*2.3.6 Acoustic resonant mixing*

Acoustic resonant mixing (RAM) is used to combine the API and co-crystal former in the existence of a solvent to produce a co-crystal without any milling media. The supply of mechanical energy into a wet powder mixture is performed acoustically, promoting the complete intermixing of the constituents. Utilizing a laboratory RAM resonant acoustic blender operating at 80−100G and 60 Hz, a series of carbamazepine co-crystals have been efficaciously formed. The co-crystal product has been separated at a wide array of gauges from the lab, 100 mg, 1.5 g, and 22 g, and the equipment seems to hold itself up to scale [37].
