**3.1 Analyzing structure through XRD**

Powder-XRD and SC-XRD are two techniques extensively used for the structure determination of solids having single large crystal and solid in the powder form, respectively. The SC-XRD elucidates the structural properties such as lattice parameters, unit cell, space group, and intermolecular interactions and is the most reliable technique [31]. However, the drawback of the method is that obtaining single crystals is a difficult task and PXRD cannot differentiate between co-crystal and additional solid states such as polymorph, solvate, and hydrate [33].

**Figure 3.** *Techniques for characterization of co-crystals.*
