**2.4 Nano co-crystallization**

Pharmaceutical nano co-crystals can considerably enhance the delivery qualities of ailing decipherable medicines, which have long posed a considerable issue for the pharmaceutical business. The investigation is into the production of nano co-crystals with high commercial value. Methods such as precipitation, media grinding, and high-pressure homogenization can be used to manufacture nanocrystals on a large scale. When delivered orally, intravenously, pulmonaryly, ocularly, or topically, nanocrystals exhibited the promising therapeutic utility. In addition, nanostructured medicinal molecules can be targeted to specific locations. Usually formation process for the nano-crystals comprising top-down flow process is a ball grinding technique that uses shear forces to produce high-pressure homogeneous nano-size particles. Precipitation is one of the bottom-up procedures that includes the growth [40].
