**Abstract**

In this chapter, we describe the most deadly heart diseases, including the fourth parts: Anatomy of the heart, chronic coronary syndrome and acute coronary syndrome and STEMI, Cardiomyopathy, and Pulmonary embolism. The written structure of a component includes Abstract, Pathophysiology, Clinical diagnostic criteria, histopathology, and cytopathology. The content is summarized based on the recommendations of the American Heart Association and the European Society of Cardiology. All images in this chapter are data at our center. In the chapter, we will see the relationship between histopathology and cytopathology and pathophysiology, which will serve as a basis for us to have more studies in the future.

**Keywords:** anatomy of the heart, coronary artery disease, cardiomyopathy, pulmonary embolism, histopathology and cytopathology
