**10.4 Detection of hereditary predisposition to cancer**

Germline mutations in many tumor suppressor genes are associated with increased risk for specific cancers. This will help in prophylactic surgery and counseling of relatives at risk, for example, BRCAI, BRCA2, and the RET protooncogene.

For therapeutic decision, It is useful in target therapy [27–29] (**Table 10**).
