**3.1 Global impact of cancer**

2018 ! 9.5 million deaths were caused by cancer worldwide, one in six deaths.


M/C cancer in men ! prostate, lung, colon, rectum.

M/C cancer in women ! breast, lung, colon/rectum.

Environmental factors although both genetic and environmental factors contribute, Environmental influences are the dominant risk factors for most cancers. Incidence of cancer increases with age due to according of somatic mutations and decrease in immune competence in older individual [2–5].
