**Abstract**

Inhaled drugs, commonly used for the treatment of chronic lung disease, are intended to have their effect quickly reach the airways and are less absorbed into the bloodstream. As ascorbic acid can be dangerous at high dosages, the inhalation route can be a substitute for getting a rapid topical elevated level of ascorbic acid. Drug/ vitamin with inhalation route has an advantage as a non-invasive route, minimal side-effect, fast-onset, no first-pass metabolism, and more potent pharmacodynamics drug. The relationship between the effect of ascorbic acid in the form of inhalation on the sinonasal mucosal immune system needs to be studied, considering the role of ascorbic acid in the prevention and plausible prognosis of pandemic era.

**Keywords:** inhalation, ascorbic acid, sinonasal immune system, neutrophil chemotaxis, neutrophil
