**5. Huntington's disease**

Huntington's disease (HD) is reported to be an autosomal dominant neurodegenerative disorder caused by the expansion of CAG trinucleotide repeats in the aminoterminal region of the huntingtin protein [25–27]. It is characterized by involuntary choreiform movements, behavioral and psychiatric disorders. It has been reported to primarily affect the nervous system for unknown reasons [25, 27]. HD leads to neuronal loss in the striatum, causing severe motor and cognitive impairments. HD exhibits a deficiency in ascorbate release in the striatum during behavioral activity periods [6]. In the striatum, the main target of HD-related neuropathology, extracellular VC levels are significantly reduced in HD mouse models [28].
