*Inhalation of Ascorbic Acid Modulates Sinonasal Immune System DOI: http://dx.doi.org/10.5772/intechopen.110891*

Drug/vitamin with inhalation route has advantage as a non-invasive route, minimal side-effect, fast-onset, no first-pass metabolism, and more potent pharmacodynamics drug, so the patient's compliance and convenience can be maximized [24]. The previous researches have been reported about the role of inhalation vitamin in some diseases. Bhat et al. (2020) reported about the role of inhaled vitamin E in electronic-cigarette, or vaping, product use-associated lung injury (EVALI), while Gelfand et al. (2020) reported about the role of inhaled vitamin A was more potent than intramuscular route in preventing hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia [28, 29].

There was one research about the effect of intranasal ascorbic acid in allergic condition. Intranasal ascorbic acid reduced ROS parameter (intracellular ROS and 8-isoprostanes), NFкB, IL-4 and IL-5, IgE and IgG1, lymphocyte proliferation, Airway Hyper Responsiveness (AHR), and lung inflammation. Intranasal ascorbic acid also increased glutathione peroxidases (GPx) activity, IL-10 level, and induced FOXP3+ cells [30]. There is a potency about the use of ascorbic acid in the inhalation route, but until now, there is no the research about it.
