**4.3 Depression**

Some patients with depressive disorders on citalopram were involved in a clinical trial with vitamin C (1000 mg/day) and placebo for 8 weeks [42]. The result showed no significant benefit in the mood of the patients. In contrast, supplementation with a higher dosage (3000 mg/day) in earlier studies demonstrated significant

improvement in mood (reduced Beck's depression scores) and sexual activity [49], as well as decreased blood pressure and subjective stress response to social stress test [50]. Therefore, it is not out of place to postulate that the dosage of vitamin C is crucial to its effect in depressive disorders.
