**4. Conclusion**

Since the day it was defined, vitamin C has been the subject of research for the treatment of a wide range of diseases. Due to differences in the data obtained from the studies, there is no consensus on its therapeutic and adverse effects. The benefits of vitamin C should not be underestimated, although its only proven therapeutic efficacy is reported to be on scurvy. It is important to know that the most reliable source of vitamin C is what we consume through food. If necessary, the consumption of supplements in doses not exceeding 1000 mg per day is also recommended.

The reason why the effects of vitamin C on the kidney vary across studies is still unclear. Theoretically, oxalate formed as a result of vitamin C metabolism should cause stone formation. However, variables such as the amount of vitamin C used in the studies, the variety of drugs given to patients, the differences in the patient population, and the duration of use have resulted in disparities in kidney stone outcomes. Similarly, it is expected to exert an antioxidant effect on nephropathy. However, there are studies that show the opposite result. Pharmacokinetic parameters that may not have been elucidated in humans should also be considered as the reason for these differences. In order to minimize adverse effects, new dose-controlled studies need to be conducted, and differences between studies need to be clarified. Studies that will clarify the therapeutic efficacy of vitamin C will provide the basis for its safe use to become widespread.

*Ascorbic Acid – Biochemistry and Functions*
